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Membre du personnel

Johan WOUTERS

Professeur ordinaire

Téléphone: 081/724550
Fax: 081/725440
Mail:

Charges aux FUNDP

Diplômes

Docteur (avec thèse)

Domaines de compétences

Chimie physique structurale

Cristallographie

Modélisation moléculaire

Chimie Médicinale

Charges externes

Comité National de Cristallographie (Académies des Sciences), secrétaire adjoint

Distinctions

1991 : Prix Société Royale de Chimie (Belgique)

1994 : Prix Société Hongroise de Neurochimie

1995 : Prix Jean STAS, Académie Royale de Belgique

2008 : Prix triennal de la Société Royale de Chimie (Belgique)

Cours (titulaire)

Projets en cours

Doctorats en cours

Anciens projets

Publications (207)

Livres

2011
Pharmaceutical Salts and Co-crystals, RSC Drug Discovery, Johan Wouters (Editor), Luc Quéré (Editor) ISBN: 978-1-84973-158-4
Johan WOUTERS

Contributions à des ouvrages collectifs

2011
Structures of class C beta-lactamases and perspectives in drug design in Beta-lactamases (JM Frere Editor) Novapublisher
Johan WOUTERS, Cedric BAUVOIS
2007
Crystal structures of class C β-lactamases: mechanistic implications and perspectives in drug design, in Enzyme-mediated resistance to antibiotics : mechanisms, dissemination, and prospects for inhibition, pp. 145-161
Cedric BAUVOIS, Johan WOUTERS
2006
Benefits and limits of in Silico predictions, in Virtual ADMET assessment in target selection and maturation, collection Solvay pharmaceuticals conferences, volume 6, pp. 15-28
Johan WOUTERS
2004
Modeling of human monoamine oxidase A : from low resolution threading models to accurate comparative models based on crystal structures, in Monoamine oxidases: molecular, pharmacological and neurotoxicological aspects, pp. 47-61
Nadia LEONARD, Christophe LAMBERT, Eric DEPIEREUX, Johan WOUTERS
1993
Structural and theoretical study of 5-(R)-(methoxymethyl)-3-aryl-oxazolidin-2-ones, reversible monoamine oxidase inhibitors, in Trends in QSAR and molecular modelling 92, pp. 291-293
Johan WOUTERS, Florence MOUREAU, Magdalena DORY, Guy EVRARD, J.J. KOENIG, F. DUCREY, F.X. JARREAU, François DURANT

Articles de périodique

2012
Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase, in Proceedings of the National Academy of Sciences, PNAS 2012 ; published ahead of print January 30, 2012, doi:10.1073/pnas.1113873109
Luc PILOTTE, Pierre LARRIEU, Vincent STROOBANT, Didier COLAU, Eduard DOLUSIC, Raphael FRÉDÉRICK, Etienne DE PLAEN, Catherine UYTTENHOVE, Johan WOUTERS, Bernard MASEREEL, Benoit VAN DEN EYNDE
2012
Unprecedented copper(I) bifluoride complexes: synthesis, characterization and reactivity, in Chem. Eur. J., volume 18, pp. 793-798
Thomas VERGOTE, Fady NAHRA, Alexandre WELLE, Michel LUHMER, Johan WOUTERS, Nathalie MAGER, Olivier RIANT, Tom LEYSSENS
2012
Advances in pharmaceutical co-crystal screening: effective co-crystal screening through structural resemblance, volume 12, pp. 475-484
Géraldine SPRINGUEL, Bernadette NORBERG, Koen ROBEYNS, Johan WOUTERS, Tom LEYSSENS
2011
Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: new structural insight into the HIV-1 integrase inhibition, in European journal of medicinal chemistry, volume 46, pp. 1749-1756
Pierre VANDURM, Allan GUIGUEN, Christine CAUVIN, Benoit GEORGES, Kiet LE VAN, Catherine MICHAUX, Christelle CARDONA, Gladys MBEMBA, Jean-François MOUSCADET, Laszlo HEVESI, Carine VAN LINT, Johan WOUTERS
2011
Electrostatically-driven assembly of MWCNTs with a europium complex, in Chem. Commun., volume 47, pp. 1625-1627
Laura MAGGINI, Hassan TRABOULSI, K. YOOSAF, John MOHANRAJ, Johan WOUTERS, Oksana PIETRASZKIEWICZ, Marek PIETRASZKIEWICZ, Nicola ARMAROLI, Davide BONIFAZI
2011
Synthesis and catalytic evaluation of ruthenium-arene complexes bearing imidazol(in)ium-2-thiocarboxylate ligands, in Organometallics, volume 30, pp. 6133-6142
Morgan HANS, Quentin WILLEM, Johan WOUTERS, Albert DEMONCEAU, Lionel DELAUDE
2011
Synthesis and organocatalytic applications of imidazol(in)ium-2-thiocarboxylates, in Eur. J. Org. Chem., volume 2011, pp. 7083-7091
Morgan HANS, Johan WOUTERS, Albert DEMONCEAU, Lionel DELAUDE
2011
Tryptophan 2,3-dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators, in Journal of Medicinal Chemistry, volume 54, issue 15, pp. 5320-5334
Eduard DOLUSIC, Pierre LARRIEU, Laurence MOINEAUX, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Lionel POCHET, Benoît VAN DEN EYNDE, Bernard MASEREEL, Johan WOUTERS, Raphael FRÉDÉRICK
2011
Acid-base modulation of a versatile heteroditopic calix[6]arene based receptor, in Biomol. Chem., volume 9, pp. 6373-6384
Damien CORNUT, Jérôme MARROT, Johan WOUTERS, Ivan JABIN
2011
Discovery and preliminary SARs of Keto-Indoles as Novel Indoleamine 2,3-Dioxygenase (IDO) Inhibitors, in European Journal of Medicinal Chemistry, volume 46, issue 7, pp. 3058-3065
Eduard DOLUSIC, Pierre LARRIEU, Sébastien BLANC, Frédéric SAPUNARIC, Jenny POUYEZ, Laurence MOINEAUX, Delphine COLETTE, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Thierry FERAIN, Graeme FRASER, Moreno GALLENI, Jean-Marie FRÈRE, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2011
4-Nitro-N-phtalyl-L-tryptophan, in Acta Crystallographica. Section E, volume 67, pp. 2116-1-8
Anaëlle TILBORG, Irving BOITTIAUX, Bernadette NORBERG, Didier LAMBERT, Johan WOUTERS
2011
Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors, in Bioorganic & Medicinal Chemistry, volume 19, issue 4, pp. 1550-1561
Eduard DOLUSIC, Pierre LARRIEU, Sébastien BLANC, Frédéric SAPUNARIC, Bernadette NORBERG, Laurence MOINEAUX, Delphine COLETTE, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Thierry FERAIN, Graeme FRASER, Moreno GALLENI, Jean-Marie FRÈRE, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2011
Inhibition studies on enzymes involved in isoprenoid biosynthesis. Focus on two potential drug targets: DXR and IDI-2 enzymes, in Current Enzyme Inhibition, volume 7, pp. 79-95
Jerome DE RUYCK, Johan WOUTERS, C. Dale POULTER
2011
Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors, in Bioorganic & medicinal chemistry, volume 19, pp. 134-144
Jérémy RENIERS, Severine ROBERT, Raphael FRÉDÉRICK, Bernard MASEREEL, Stephane VINCENT, Johan WOUTERS
2011
Structural study of piracetam polymorphs and cocrystals: crystallography redetermination and quantum mechanics calculations, in Acta Cryst., volume B67, pp. 499-507
Anaëlle TILBORG, Denis JACQUEMIN, Bernadette NORBERG, Eric PERPÈTE, Catherine MICHAUX, Johan WOUTERS
2011
Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indenol[1,2-c]pyridazin-5-one derivatives, in European journal of medicinal chemistry, volume 46, pp. 6104-6111
Jérémy RENIERS, Céline MEINGUET, Laurence MOINEAUX, Bernard MASEREEL, Stephane VINCENT, Raphael FRÉDÉRICK, Johan WOUTERS
2011
The 5-HT1A agonism potential of substituted piperazine-ethyl-amide derivatives is conserved in the hexyl homologues: molecular modeling and pharmacological evaluation, in Journal of chemical information and modeling, volume 51, pp. 2961-2966
Sébastien DILLY, Jacqueline SCUVÉE-MOREAU, Johan WOUTERS, Jean-François LIÉGEOIS
2010
An allosteric heteroditopic receptor for neutral guests and contact ion pairs with a remarkable selectivity for ammonium fluoride salts, in Organic & biomolecular chemistry, volume 8, pp. 4607-4616
Angélique LASCAUX, Stéphane LE GAC, Johan WOUTERS, Ivan JABIN
2010
Bis-tetrahydroisoquinoline derivatives: structure analysis of the three stereoisomers of 1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline), in European journal of medicinal chemistry, volume 45, pp. 3240-3244
Johan WOUTERS, Kossay ELASAAD, Bernadette NORBERG, Amaury GRAULICH, Jean-François LIÉGEOIS
2010
Electrostatically-driven assembly of MWCNTs with a europium complex, in Chem. Commun.
Laura MAGGINI, Hassan TRABOULSI, K. YOOSAF, John MOHANRAJ, Johan WOUTERS, Oksana PIETRASZKIEWICZ, Marek PIETRASZKIEWICZ, Nicola ARMAROLI, Davide BONIFAZI
2010
Advantages of cocrystallization in the field of solid-state pharmaceutical chemistry: L-Proline and MnCl2, in European journal of medicinal chemistry, volume 45, pp. 3511-3517
Anaëlle TILBORG, Catherine MICHAUX, Bernadette NORBERG, Johan WOUTERS
2010
On the fractional crystallization of palm olein: solid solutions and eutectic solidification, in Food research international
Gijs CALLIAUW, Eveline FREDRICK, Veronique GIBON, Wim DE GREYT, Johan WOUTERS, Imogen FOUBERT, Koen DEWETTINCK
2010
Overproduced Brucella abortus PdhS-mCherry forms soluble aggregates in Escherichia coli, partially associating with mobile foci of IbpA-YFP., in BMC Microbiol, volume 10, pp. 248
Charles VAN DER HENST, CHARLIER, Michaël DEGHELT, Johan WOUTERS, Jean-Yves MATROULE, Jean-Jacques LETESSON, Xavier DE BOLLE
2010
Physiochemical properties of European bakery margarines with and without trans fatty acids, in Journal of food lipids, volume 16, pp. 273-286
V. CAVILLOT, C. PIERART, Marie KERVYN DE MEERENDRE, Michaël VINCENT, M. PAQUOT, Johan WOUTERS, C. DEROANNE, S. DANTHINE
2010
Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NK-κB activation, in Biochemical pharmacology, volume 79, pp. 1462-1472
Jérémie MORTIER, Raphael FRÉDÉRICK, Corinne GANEFF, Caroline REMOUCHAMPS, Patrice TALAGA, Lionel POCHET, Johan WOUTERS, Jacques PIETTE, Emmanuel DEJARDIN, Bernard MASEREEL
2010
Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling, in ChemBioChem, volume 11, pp. 218-227
Geoffray LABAR, Cédric BAUVOIS, Franck BOREL, Jean-Luc FERRER, Johan WOUTERS, Didier LAMBERT
2010
Engineering solid-state molecular switches: N-salicylidene N-heterocycle derivatives, in Eur. J. Org. Chem., pp. 621-637
François ROBERT, Anil NAIK, Florence HIDARA, Bernard TINANT, Raphaël ROBIETTE, Johan WOUTERS, Yann GARCIA
2010
Cobalt(II) complexes of nitrile-functionalized ionic liquids, in Chem. Eur. J., volume 16, pp. 1849-1858
Peter NOCKEMANN, Michael PELLENS, Kristof VAN HECKE, Luc VAN MEERVELT, Johan WOUTERS, Ben THIJS, Evert VANECHT, Tatjana PARAC-VOGT, Hasan MEHDI, Stijn SCHALTIN, Jan FRANSAER, Stefan ZAHN, Barbara KIRCHNER, Koen BINNEMANS
2010
Copper-catalysed domino silylative aldol reaction leading to stereocontrolled chiral quaternary carbons, in Chem. Eur. J., volume 16, pp. 10980-10983
Alexandre WELLE, Julien PETRIGNET, Bernard TINANT, Johan WOUTERS, Olivier RIANT
2010
Analysis of the interactions taking place in the recognition site of a bimetallic Mg(II)-Zn(II) enzyme, isopentenyl diphosphate isomerase: a parallel quantum-chemical and polarizable molecular mechanics study, in J. Phys. Chem. B, volume 114, pp. 4884-4895
Nohad GRESH, Nicole AUDIFFREN, Jean-Philippe PIQUEMAL, Jerome DE RUYCK, Marie LEDECQ, Johan WOUTERS
2010
endo-3,3-Dimethyl-4-oxobicyclo[3.1.0]hexan-2-yl methanesulfonate, in Acta crystallographica. Section E: Structure reports, volume E66, issue 0948
Adrian KREMER, Bernadette NORBERG, Alain KRIEF, Johan WOUTERS
2010
The dicyclohexylamine salt of RG108 (N-phthalyl-L-tryptophan), a potential epigenetic modulator, in Acta Crystallographica. Section E, volume 66, pp. 3175-10
Julie BRAUN, Irving BOITTIAUX, Anaëlle TILBORG, Didier LAMBERT, Johan WOUTERS
2010
A review on the monoacylglycerol lipase: at the interface between fat and endocannabinoid signalling, in Current medicinal chemistry, volume 17, pp. 2588-2607
Geoffray LABAR, Johan WOUTERS, D. LAMBERT
2009
Electronic transitions of neutral and anionic quinolinone HIV-1 integrase inhibitor: joint theory/experiment investigation, in Chemical physics letters, volume 478, pp. 243-248
Pierre VANDURM, Christine CAUVIN, Johan WOUTERS, Eric PERPÈTE, Denis JACQUEMIN
2009
Structural and theoretical studies of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoïc acid as HIV-1 integrase inhibitor, in Bioorganic & medicinal chemistry letters, volume 19, pp. 4806-4809
Pierre VANDURM, Christine CAUVIN, Allan GUIGUEN, Benoit GEORGES, Kiet LE VAN, Valérie MARTINELLI, Christelle CARDONA, Gladys MBEMBA, Jean-François MOUSCADET, Laszlo HEVESI, Carine VAN LINT, Johan WOUTERS
2009
Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors, in Bioorganic and Medicinal Chemistry, volume 17, pp. 553-557
Anne THIRY, Marie LEDECQ, Alessandro CECCHI, Raphael FRÉDÉRICK, Jean-Michel DOGNÉ, Johan WOUTERS, Bernard MASEREEL, Claudiu T. SUPURAN
2009
Comparing the crystallization and polymorphic behaviour of saturated and unsaturated monoglycerides, in Food research international, volume 42, pp. 1415-1425
Jeroen VEREECKEN, Wouter MEEUSSEN, Imogen FOUBERT, Ans LESAFFER, Johan WOUTERS, Koen DEWETTINCK
2009
Ab initio investigation of the hydration of deprotonated amino acids, in J Am Soc Mass Spectrom, volume 20, pp. 632-638
Catherine MICHAUX, Johan WOUTERS, Eric PERPÈTE, Denis JACQUEMIN
2009
Structure and X-ray conformation of pseudodesmins A and B, two new cyclic lipodepsipeptides from Pseudomonas bacteria, in Tetrahedron, volume 65, pp. 4173-4181
Davy SINNAEVE, Catherine MICHAUX, Johan VAN HEMEL, Jan VANDENKERCKHOVE, Eric PEYS, Frans BORREMANS, Benedikt SAS, Johan WOUTERS, José MARTINS
2009
Synthesis and biological evaluation of a new family of anti-benzylanilinosulfonamides as CA IX inhibitors, in European journal of medicinal chemistry, volume 44, pp. 511-518
Anne THIRY, Aurélie DELAYEN, Laurence GOOSSENS, Raymond HOUSSIN, Marie LEDECQ, Aurélie FRANKART, Jean-Michel DOGNÉ, Johan WOUTERS, Claudiu T. SUPURAN, Jean-Pierre HENICHART, Bernard MASEREEL
2009
Assessing the potential of zwitterionic NHC-CS2 adducts for probing the stereoelectronic parameters of N-heterocyclic carbenes, in Eur. J. Inorg. Chem., pp. 1882-1891
Lionel DELAUDE, Albert DEMONCEAU, Johan WOUTERS
2009
Conformation-controlled networking of H-bonded assemblies on surfaces: , in Chem. Commun., pp. 3525-3527
Manfred MATENA, Anna LLANES-PALLAS, Mihaela ENACHE, Thomas JUNG, Johan WOUTERS, Benoît CHAMPAGNE, Meike STÖHR, Davide BONIFAZI
2009
Xylanase XYL1p from Scytalidium acidophilum: site-directed mutagenesis and acidophilic adaptation, in Bioresource technology, volume 100, pp. 6465-6471
Bassam AL BALAA, Kristof BRIJS, Kurt GEBRUERS, Jean VANDENHAUTE, Johan WOUTERS, Isabelle HOUSEN
2009
Synthesis and catalytic evaluation of ruthenium-arene complexes generated using imidazol(in)ium-2-carboxylates and dithiocarboxylates, in Organometallics, volume 28, pp. 4056-4064
Lionel DELAUDE, Xavier SAUVAGE, Albert DEMONCEAU, Johan WOUTERS
2008
Structure-based drug design targeting biosynthesis of isoprenoïds: a crystallographic state of the art of the involved enzymes, in Current Protein and Peptide Sciences, volume 9, issue 2, pp. 117-137
Jerome DE RUYCK, Johan WOUTERS
2008
A MBP-FAAH fusion protein as a tool to produce human and rat fatty acid amide hydrolase: expression and pharmacological comparison, in Amino acids, volume 34, pp. 127-133
G. LABAR, F. VLIET, Johan WOUTERS, D. LAMBERT
2008
Stepwise hydration of protonated proline, in Journal of physical chemistry letters. B, volume 112, pp. 7702-7705
Catherine MICHAUX, Johan WOUTERS, Eric PERPÈTE, Denis JACQUEMIN
2008
Microhydration of protonated glycine: an ab initio family tree, in J. Phys. Chem. B, volume 112, pp. 2430-2438
Catherine MICHAUX, Johan WOUTERS, Eric PERPÈTE, Denis JACQUEMIN
2008
Modeling the microhydration of protonated alanine, in J. Phys. Chem. B, volume 112, pp. 9896-9902
Catherine MICHAUX, Johan WOUTERS, Eric PERPÈTE, Denis JACQUEMIN
2008
The crystal structure of sursassite from the Lienne valley, Stavelot massif, Belgium, in Eur. J. Mineral., volume 20, pp. 993-998
Frédéric HATERT, André-Mathieu FRANSOLET, Johan WOUTERS, Heinz-Jürgen BERNHARDT
2008
Crystal structure of a cold-adapted C Beta-lactamase, in FEBS journal, volume 275, pp. 1687-1697
Catherine MICHAUX, Jan MASSANT, Frédéric KERFF, Jean-Marie FRÈRE, Jean-Denis DOCQUIER, Isabel VANDENBERGHE, Bart SAMYN, Annick PIERRARD, Georges FELLER, Paulette CHARLIER, Jozef VAN BEEUMEN, Johan WOUTERS
2008
Crystal structure of type 2 isopentenyl diphosphate isomerase from Thermus thermophilus in complex with inorganic pyrophosphate, in Biochemistry, volume 47, issue 35, pp. 9051-9053
Jerome DE RUYCK, Jenny POUYEZ, Steven C. ROTHMAN, C. Dale POULTER, Johan WOUTERS
2008
Modeling of sucrose crystallization kinetics: the influence of glucose and fructose, in Journal of crystal growth, volume 310, pp. 3498-3503
S. OUIAZZANE, B. MESSNAOUI, S. ABDERAFI, Johan WOUTERS, T. BOUNAHMIDI
2008
Protecting role of cosolvents in protein denaturation by SDS: a structural study, in BMC structural biology, volume 8, issue 29
Catherine MICHAUX, Jenny POUYEZ, Johan WOUTERS, Gilbert PRIVÉ
2008
Monoclinic form of isopentenyl diphosphate isomerase: a case of polymorphism in biomolecular crystals., in Acta Crystallographica Section F, volume F64, pp. 239-242
Jerome DE RUYCK, Yamina OUDJAMA, Johan WOUTERS
2008
Species distribution and coordination of uranyl chloro complexes in acetonitrile, in Inorganic chemistry, volume 47, pp. 2987-2993
Christoph HENNIG, Kelly SERVAES, Peter NOCKEMANN, Kristof VAN HECKE, Luc VAN MEERVELT, Johan WOUTERS, Linda FLUYT, Christiane GÖRLLER-WALRAND, Rik VAN DEUN
2008
A Single E141A mutation in the xylanase XYL1p from Scytalidium acidophilum improves its activity at pH 4.0
Bassam AL BALAA, Kristof BRIJS, Kurt GEBRUERS, Jean VANDENHAUTE, Johan WOUTERS, Isabelle HOUSEN
2008
Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca2+-activated K+ channel blockers, in Bioorganic & medicinal chemistry letters, volume 18, pp. 3440-3445
Amaury GRAULICH, Cédric LAMY, Livia ALLEVA, Sébastien DILLY, Philippe CHAVATTE, Johan WOUTERS, Vincent SEUTIN, Jean-François LIÉGEOIS
2008
New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)2H-1-benzopyrans strcturally related to (±)-cromakalim as tissue-selective pancreatic β-cell KATP channel openers, in Bioorganic & medicinal chemistry, volume 16, pp. 5704-5719
Sophie SEBILLE, Pascal DE TULLIO, Xavier FLORENCE, Bénédicte BECKER, Marie-Hélène ANTOINE, Catherine MICHAUX, Johan WOUTERS, Bernard PIROTTE, Philippe LEBRUN
2008
Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation, in European journal of medicinal chemistry, volume 43, pp. 2853-2860
Anne THIRY, Stéphanie ROLIN, Daniela VULLO, Aurélie FRANKART, Andrea SCOZZAFAVA, Jean-Michel DOGNÉ, Johan WOUTERS, Claudiu T. SUPURAN, Bernard MASEREEL
2007
A MBP-FAAH fusion protein as a tool to produce human and rat fatty acid amide hydrolase: expression and pharmacological comparison, in Amino acids
G. LABAR, F. VLIET, Johan WOUTERS, D. LAMBERT
2007
Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling, in ChemBioChem, volume 8, pp. 1293-1297
Geoffray LABAR, Cédric BAUVOIS, Giulio MUCCIOLI, Johan WOUTERS, Didier LAMBERT
2007
Mechanism-Based Thrombin Inhibitors: Design, Synthesis, and Molecular Docking of a New Selective 2-Oxo-2H-1-benzopyran Derivative, in Journal of Medicinal Chemistry, volume 50, pp. 3645-3650
Raphael FRÉDÉRICK, Severine ROBERT, Caroline CHARLIER, Johan WOUTERS, Bernard MASEREEL, Lionel POCHET
2007
(±)-2-Benzoyl-8-ethyl-1,2-dihydro-isoquinoline-1-carbonitrile: an original Reissert compound, in Acta crystallographica. E, volume 63, pp. 3161-1-8
A. GRAULICH, Bernadette NORBERG, J.-F. LIÉGEOIS, Johan WOUTERS
2007
Overexpression, physicochemical characterization, and modeling of a hyperthermophilic Pyrococcus furiosus type 2 IPP isomerase, in Proteins, volume 71, pp. 1699-1707
Raphael DUTOIT, Jerome DE RUYCK, Virginie DURISOTTI, Christianne LEGRAIN, Eric JACOBS, Johan WOUTERS
2007
Towards the understanding of the absorption spectra of NAD(P)H/NAD(P)+ as a common indicator of dehydrogenase enzymatic activity, in Chemical Physics Letters, volume 450, pp. 119-122
Jerome DE RUYCK, Maureen FAMERÉE, Johan WOUTERS, Eric PERPÈTE, Julien PREAT, Denis JACQUEMIN
2007
Exploration of the binding mode of indanesulfonamides as selective inhibitors of human carbonic anhydrase type VII by targeting Lys91, in ChemMedChem, volume 2, issue 9, pp. 1273-1280
Anne THIRY, Bernard MASEREEL, Jean-Michel DOGNÉ, Claudiu T. SUPURAN, Johan WOUTERS, Catherine MICHAUX
2007
A theoretical investigation of the hydrated glycine cation energetics and structures, in Chemical physics letters, volume 445, pp. 57-61
Catherine MICHAUX, Johan WOUTERS, Denis JACQUEMIN, Eric PERPÈTE
2006
Investigation of mechanism-based thrombin inhibitors: implications of a highly conserved water molecule for the binding of coumarins within the S pocket, in Bioorganic and Medicinal Chemistry Letters, volume 16, issue 7, pp. 2017-2021
Raphael FRÉDÉRICK, Caroline CHARLIER, Severine ROBERT, Johan WOUTERS, Bernard MASEREEL, Lionel POCHET
2006
Structural insights into human 5-lipoxygenase inhibition: combined ligand-based and target-based approach, in Journal of medicinal chemistry, volume 49, pp. 186-195
Caroline CHARLIER, Jean-Pierre HÉNICHART, François DURANT, Johan WOUTERS
2006
Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: comparison with two original compounds, OL-92 and JP104, in Bioorganic & Medicinal Chemistry Letters, volume 16, issue 18, pp. 4772-4776
Catherine MICHAUX, Giulio MUCCIOLI, Didier LAMBERT, Johan WOUTERS
2006
(3R,5S,6R,8S,9S)-1-Azonia-9-ethyl-3-hydroxy-5-(6-methoxyquinolin-4-yl)-3-methyl-4-oxa-tricyclo[6.2.2.0]dodecane trifluoromethanesulfonate: insight into the sterochemistry of the cyclization mechanism, in Acta crystallographica. Section E: Structure reports, volume E62, pp. 2864-2865
Gema ANTEQUERA-GARCIA, Bernadette NORBERG, Istvan MARKO, Johan WOUTERS
2006
Synthesis, structural reassignment and biological activity of type B MAO inhibitors based on the 5H-indeno-[1,2-c]pyridazin-5-one core, in Journal of Medicinal Chemistry, volume 49, issue 12, pp. 3743-3747
Raphael FRÉDÉRICK, Willy DUMONT, Frederic OOMS, Cornelis VAN DER SCHYF, Lindsey ASCHENBACH, Neal CASTAGNOLI, Johan WOUTERS, Alain KRIEF
2006
2,6-Dihydroxyanthraquinone: an isomer of the well known alizarin dye, in Acta Crystallographica Section E , volume E62, pp. 4503-4505
Jerome DE RUYCK, Julien PREAT, Denis JACQUEMIN, Eric PERPETE, Johan WOUTERS
2006
2,6-dihydroxyanthraquinone: an isomer of the well known alizarin dye, in Acta crystallographica. E, volume 62, pp. O4503-O4505
Jerome DE RUYCK, Julien PREAT, Eric PERPÈTE, Denis JACQUEMIN, Johan WOUTERS
2006
Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists, in J. Mol. Chem. , volume 49, pp. 872-882
Giulio MUCCIOLI, Johan WOUTERS, Caroline CHARLIER, Gerhard SCRIBA, Teresa PIZZA, Pierluigi DI PACE, Paolo DE MARTINO, Wolfgang POPPITZ, Jacques POUPAERT, Didier LAMBERT
2006
Indanesulfonamides as carbonic anhydrase inhibitors: toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX, in Journal of Medicinal Chemistry, volume 49, issue 9, pp. 2743-2749
Anne THIRY, Marie LEDECQ, Alessandro CECCHI, Jean-Michel DOGNÉ, Johan WOUTERS, Claudiu T. SUPURAN, Bernard MASEREEL
2006
Identification, cloning, and expression of the Scytalidium acidophilum XYLI gene encoding for an acidophilic xylanase, in Bioscience Biotechnology Biochemistry, volume 70, issue 1, pp. 269-272
Bassam AL BALAA, Johan WOUTERS, Sophie DOGNÉ, Carlos ROSSINI, Jean-Michel SCHAUS, Eric DEPIEREUX, Jean VANDENHAUTE, Isabelle HOUSEN
2006
Structural role for Tyr 104 in E. coli isopentenyl diphosphate isomerase: site-directed mutagenesis, enzymology and protein crystallography, in Journal of Biological Chemistry, volume 281, pp. 17864-17869
Jerome DE RUYCK, Virginie DURISOTTI, Yamina OUDJAMA, Johan WOUTERS
2006
{4(S)-(Piperidin-1-ylcarbonyl)-4-[3-(trifluoromethyl)phenylsulfon-amido]butyl}guanidinium chloride: a model of a graftable thrombin inhibitor, in Acta crystallographica. Section C: Crystal structure communications, volume C62, pp. 691-693
Catherine MICHAUX, Claudio SALVAGNINI, Bernadette NORBERG, Jacqueline MARCHAND-BRYNAERT, Johan WOUTERS
2006
(2RS,5SR,6SR)-Methyl 4-{cis-2-[3-fluoro-5-(4-methoxy-3,4,5,tetrahydro-2H-pyran-4-yl)phenoxymethyl]-6-hydroxy-3-phenylmorpholino}benzenesulfinate, in Acta crystallographica. Section C: Crystal structure communications, volume C62, pp. o92-o94
Caroline CHARLIER, Aurélie DELAYEN, Bernadette NORBERG, Jean-Pierre HÉNICHART, Johan WOUTERS
2005
A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase, in Journal of the American chemical society, volume 127, pp. 536-537
Johan WOUTERS, Fenglin YIN, Yongcheng SONG, Yonghui ZHANG, Yamina OUDJAMA, Victor STALON, Louis DROOGMANS, Craig MORITA, Eric OLDFIELD
2005
Substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one as CB1 cannabinoid receptor ligands: synthesis and pharmacological evaluation, in Journal of medicinal chemistry, volume 48, issue 7, pp. 2509-2517
Giulio MUCCIOLI, Diana MARTIN, Gerhard SCRIBA, Wolfgang POPPITZ, Jacques POUPAERT, Johan WOUTERS, Didier LAMBERT
2005
(E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B, in Acta crystallographica. Section C: Crystal structure communications, volume C61, pp. 531-532
Raphael FRÉDÉRICK, Frédéric OOMS, Neal CASTAGNOLI JR., Jacques PETZER, Jiang-Fan FENG, Michael SCHWARZSCHILD, Cornelis VAN DER SCHYF, Johan WOUTERS
2005
Design, synthesis and evaluation of graftable thrombin inhibitors for the preparation of blood-compatible polymer materials, in Organic and biomolecular chemistry, volume 3, issue 23, pp. 4209-4220
Claudio SALVAGNINI, Catherine MICHAUX, Julie REMICHE, Johan WOUTERS, Paulette CHARLIER, Jacqueline MARCHAND-BRYNAERT
2005
Overexpression, purification, crystallization and crystallographic analysis of CopK of Cupriavidus metallidurans, in Acta Crystallogaphica section F-Structural Biology and Crystallization ommunications, volume 61, issue 9, pp. 825-827
Catherine TRICOT, Sebastien VAN AELST, Ruddy WATTIEZ, Max MERGEAY, Victor STALON, Johan WOUTERS
2005
Determination of physical changes of inulin related to sorption isotherms: an X-ray diffraction, modulated differential scanning calorimetry and environmental scanning electron microscopy study, in Carbohydrate Polymers, volume 63, issue 2, pp. 210-217
S. RONKART, C. BLECKER, C. FOUGNIES, J.C. VAN HERCK, Johan WOUTERS, M. PAQUOT
2005
Differential scanning calorimetry in life science: thermodynamics, stability, molecular recognition and application in drug design, in Current medicinal chemistry, volume 12, issue 12, pp. 2011-2020
G. BRUYLANTS, Johan WOUTERS, Catherine MICHAUX
2005
3,6-disubstituted coumarins as mechanism based inhibitors of Thrombin and Factor Xa, in Journal of Medicinal Chemistry, volume 48, pp. 7592-7603
Raphael FRÉDÉRICK, Severine ROBERT, Caroline CHARLIER, Jerome DE RUYCK, Johan WOUTERS, Bernard PIROTTE, Bernard MASEREEL, Lionel POCHET
2005
Structure of Thermus thermophilus type 2 Isopentenyl Diphosphate Isomerase inferred from crystallography and molecular dynamics, in Biochemical and Biophysical Research Communications, volume 338, issue 3, pp. 1515-1518
Jerome DE RUYCK, Steven C ROTHMAN, C. Dale POULTER, Johan WOUTERS
2005
Cyproterone and a comparison with its acetate ester, in Acta Crystallographica Section E Structure Reports on line, volume E61, pp. 03576-03578
Jerome DE RUYCK, Sandrine HENRY DE HASSONVILLE, Jean-François LIÉGEOIS, Johan WOUTERS
2005
Isopentenyl diphosphate isomerase: mechanism-based inhibition by diene analogues of isopentenyl diphosphate and dimethylallyl diphosphate, in Journal of the American chemical society, volume 127, issue 3, pp. 17433-17438
Zheng WU, Johan WOUTERS, C. Dale POULTER
2005
Crystal structure of BRL 42715, C6-(N1-Methyl-1,2,3-triazolylmethylene)penem, in complex with Enterobacter cloacae 908R β-lactamase: evidence for a stereoselective mechanism from docking studies, in Journal of the American chemical society, volume 127, issue 10, pp. 3262-3263
Catherine MICHAUX, Paulette CHARLIER, Jean-Marie FRÈRE, Johan WOUTERS
2005
Sequential acid/base-catalyzed polycyclization of tryptamine derivatives: a rapid access to Büchi's Ketone, in Organic letters, volume 7, issue 23, pp. 5245-5248
Nicolas HEUREUX, Johan WOUTERS, Istvan MARKO
2005
Head-on immobilization of DNA fragments on CVD-diamond layers, in Materials Science Forum, volume 492, pp. 267-272
S WENMACKERS, P CHRISTIAENS, W DEFERME, M DAENEN, K HAENEN, M NESLADEK, P WAGNER, V VERMEEREN, L MICHIELS, M VANDEVEN, M AMELOOT, Johan WOUTERS, Zineb MEKHALIF, L NAELAERTS
2005
1-Benzhydryl-3-Pheylurea and 1-Benzhydryl-3-Phenythiourea derivatives - New templates among the CB1 cannbinoid receptor inverse agonists, in Journal of Medicinal Chemistry, volume 48, issue 23, pp. 7486-7490
Johan WOUTERS, GG MUCCIOLI, GKE SCRIBA, W POPPITZ, JH POUPEART, D LAMBERT
2004
Three 5H-indeno[1,2-c]pyridazin-5-one derivatives, potent type-B monoamine oxidase inhibitors, in Acta crystallographica. Section C: Crystal structure communications, volume C60, pp. o623-o626
Raphael FRÉDÉRICK, Bernadette NORBERG, François DURANT, Frédéric OOMS, Johan WOUTERS
2004
Modeling of human monoamine oxidase A : from low resolution threading models to accurate comparative models based on crystal structures, in Neurotoxicology, volume 25, pp. 47-61
Nadia LEONARD, Christophe LAMBERT, Eric DEPIEREUX, Johan WOUTERS
2003
A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins, in Tetrahedron, volume 59, pp. 1301-1307
Giulio MUCCIOLI, Jacques POUPAERT, Johan WOUTERS, Bernadette NORBERG, Wolfgang POPPITZ, Gerhard SCRIBA, Didier LAMBERT
2003
Rational approaches towards reversible inhibition of type B monoamine oxidase: design and evaluation of a novel 5H-indeno[1,2-c]pyridazin-5-one derivative, in Bioorganic and medicinal chemistry letters, issue 13, pp. 69-73
Frédéric OOMS, Raphael FRÉDÉRICK, François DURANT, Jacobus PETZER , Neal CASTAGNOLI, JR, Cornelis VAN DER SCHYF, Johan WOUTERS
2003
Biologie in silico: point de vue de bioinformaticiens, in Chimie nouvelle, volume 83, pp. 106-111
Christophe LAMBERT, Johan WOUTERS, Xavier DE BOLLE, Eric DEPIEREUX
2003
Wavpred: a wavelet-based algorithm for the prediction of transmembrane proteins, in Comm. math. sci., volume 1, issue 1, pp. 44-56
Patrick FISCHER, Guy BAUDOUX, Johan WOUTERS
2003
Versatile access to benzhydryl-phenylureas through an unexpected rearrangement during microwave-enhanced synthesis of hydantoins, in Organic letters, volume 5, issue 20, pp. 3599-3602
Giulio MUCCIOLI, Johan WOUTERS, Jacques POUPAERT, Bernadette NORBERG, Wolfgang POPPITZ, Gerhard SCRIBA, Didier LAMBERT
2003
A pharmacophore model for sulphonyl-urea (-cyanoguanidine) compounds with dual action, thromboxane receptor antagonists and thromboxane synthase inhibitors, in European Journal of Medicinal Chemistry, volume 38, pp. 703-710
Catherine MICHAUX, Jean-Michel DOGNÉ, Stéphanie ROLIN, Bernard MASEREEL, Johan WOUTERS, François DURANT
2002
4-Methyl-2-[N-(3,4-methylenedioxybenzylidene)hydrazino]thiazole and its reduction product, 4-methyl-2-[N-(3,4-methylenedioxybenzylidene)hydrazono]-4,5-dihydrothiazole, in Acta crystallographica. Section C: Crystal structure communications, volume C, issue 58, pp. 69-71
Johan WOUTERS, Bernadette NORBERG, Salvatore GUCCIONE
2002
Structural approach of the mechanism of inhibition of a-chymotrypsin by coumarins, in Bioorganic & Medicinal Chemistry Letters, volume 12, issue 7, pp. 1109-1112
Johan WOUTERS, Marjorie HUYGENS, Lionel POCHET, Bernard PIROTTE, François DURANT, Bernard MASEREEL
2002
The endoxylanases from family 11: computer analysis of protein sequences reveals important structural and phylogenetic relationships, in Journal of Biotechnology, volume 95, pp. 109-131
Amalia SAPAG, Johan WOUTERS, Christophe LAMBERT, Pablo DE IOANES, Jaime EYZAGUIRRE, Eric DEPIEREUX
2001
La banque de données structurales de Cambridge, un trésor d'informations, in Chimie nouvelle, issue 73, pp. 3230-3233
Luc VAN MEERVELT, Johan WOUTERS
2001
Expression, purification, crystallization and preliminary X-ray analysis of the native class C β-lactamase from Enterobacter cloacae 908R and two mutants, in Acta crystallographica. Section D: Biological crystallography, issue 57, pp. 162-164
Johan WOUTERS, P. CHARLIER, D. MONNAIE, J.-M. FRÈRE, E. FONZÉ
2001
Structure determination and comparison of BM567, a sulfonylurea, with Terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition, in Bioorganic and Medicinal Chemistry Letters, issue 11, pp. 1019-1022
Catherine MICHAUX, Stéphanie ROLIN, Jean-Michel DOGNÉ, François DURANT, Bernard MASEREEL, Jacques DELARGE, Johan WOUTERS
2001
Crystallographic analysis of gfamily 11 endo-Β-1,4-xylanase Xyl1 from Streptomyces sp. S38, in Acta crystallographica. Section D. Biological crystallography, issue D57, pp. 1813-1819
Johan WOUTERS, J. GEORIS, D. ENGHER, Jean VANDENHAUTE, J. DUSART, J.M. FRERE, Eric DEPIEREUX, P. CHARLIER
2001
Design, synthesis and biological evaluation of a sulfonylcyanoguanidine as thromboxane A2 receptor antagonist and thromboxane synthase inhibitor, in Journal of Pharmacy and Pharmacology, issue 53, pp. 669-680
Jean-Michel DOGNÉ, Johan WOUTERS, Stéphanie ROLIN, Catherine MICHAUX, Lionel POCHET, François DURANT, Jacques DELARGE, Bernard MASEREEL
2001
Small molecule crystallography in drug design, in Current pharmaceutical design, issue 7, pp. 529-545
Johan WOUTERS, Frédéric OOMS
2000
Empirical and molecular modeling study of the pyridinium species RHPP+, an abundant and potentially neurotoxic metabolite of haloperidol, in Journal of the Chemical society. Perkin transactions. 2, pp. 1781-1787
Frédéric OOMS, Sébastien DELVOSAL, Johan WOUTERS, François DURANT, Gisella DOCKENDOLF, Clinton VAN'T LAND, Thomas GLASS, Neal CASTAGNOLI, JR, Cornelis VAN DER SCHYF
2000
Isosterism among analogues of torasemide: conformational, electronic and lipophilic properties, in European Journal of Medicinal Chemistry, volume 35, pp. 923-929
Johan WOUTERS, Catherine MICHAUX, François DURANT, Jean Michel DOGNÉ, Jacques DELARGE, Bernard MASEREEL
2000
Molecular interaction between reversible MAO-A inhibitors and the enzyme: application to aryloxazolidinone, a prototype series, in Neurobiology, volume 8, issue 1, pp. 81-98
Frédéric OOMS, S. JEGHAM, Johan WOUTERS, P. GEORGE, François DURANT
2000
Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition, in Acta crystallographica Section C: Crystal Structure communications, issue 56, pp. 1265-1266
Catherine MICHAUX, Bernadette NORBERG, Jean-Michel DOGNÉ, François DURANT, Bernard MASEREEL, Jacques DELARGE, Johan WOUTERS
2000
Coumarinic derivatives as mechanism-based inhibitors of &-chymotrypsin and human leukocyte elastase, in Bioorganic and Medicinal Chemistry, issue 8, pp. 1489-1501
Lionel POCHET, Caroline DOUCET, Georges DIVE, Johan WOUTERS, Bernard MASEREEL, Michèle REBOUD-RAVAUX, Bernard PIROTTE
2000
Use of theoretical descriptors to characterize cation-π binding sites in (macro)molecules, in Journal of Computational Chemistry, volume 21, issue 10, pp. 847-855
Johan WOUTERS
2000
Purification, cloning, and three-dimensional structure prediction of Micrococcus luteus FAD-containing tyramine oxidase, in Biochemical and biophysical research communications, issue 268, pp. 293-297
Jung Hyeob ROH, Johan WOUTERS, Eric DEPIEREUX, Hideaki YUKAWA, Masayuki INUI, Hiromichi MINAMI, Hideyuki SUZUKI, Hidehiko KUMAGAI
2000
7-Nitroindazole, in Acta crystallographica. Section C: Crystal structure communications, issue 56
Frédéric OOMS, Bernadette NORBERG, Emre ISIN, Neal CASTAGNOLI, Cornelis VAN DER SCHYF, Johan WOUTERS
2000
Structural analysis of pyrrolidinones, in Acta crystallographica. Section C. Crystal structure communications, volume C, issue 56, pp. 193-196
Bernadette NORBERG, Fabrice CAMUS, Anne LEGRAND, Benoît RIGO, François DURANT, Johan WOUTERS
2000
Molecular interaction between reversible Mao-A inhibitors and the enzyme:: application to phenyloxazolidinone, a prototype series, in Chimie nouvelle, volume 17, issue 65, pp. 1999
Frédéric OOMS, Johan WOUTERS, S. JEGHAM, P. GEORGE, François DURANT
2000
Effects of a novel non-carboxylic thromboxane A2 receptor antagonist (BM-531) derived from torasemide on platelet function, in Prostaglandins Leukotrienes and Essential Fatty Acids, volume 62, pp. 311-317
Jean-Michel DOGNÉ, Xavier DE LEVAL, Philippe NEVEN, Stéphanie ROLIN, Johan WOUTERS, Jean-Louis DAVID, Jacques DELARGE, Bernard MASEREEL
2000
Pharmacomodulation studies of torasemide led to original non-carboxylic thromboxane A2 receptor antagonists, in Pharmacy and Pharmacology Communication, volume 6, pp. 77-82
Jean-Michel DOGNÉ, Xavier DE LEVAL, Philippe NEVEN, Stéphanie ROLIN, Fabian SOMERS, Johan WOUTERS, Jacques DELARGE, Bernard MASEREEL
2000
Structural Analysis of Pyrrolidinones, in Acta Crystallographica , volume 56, pp. 193-196
Fabrice CAMUS, Bernadette NORBERG, Anne LEGRAND, Benoît RIGO, François DURANT, Johan WOUTERS
2000
Structural approach of human MAO-A using fold recognition (threading) techniques, in Neurobiology, volume 8, issue 1, pp. 119-128
Johan WOUTERS, Eric DEPIEREUX, François DURANT
2000
Identification of a potential metal cation-pi binding site in the structure of a thermophilic Bacillus stearothermophilus triosephosphate isomerase mutant, in Acta crystallographica. Section D: Biological crystallography, issue 56, pp. 1201-1203
Johan WOUTERS, Dominique MAES
2000
Topology prediction of Brucella abortus Omp2b and Omp2a porins after critical assessment of transmembrane Β strands prediction by several secondary structure prediction methods, in Journal of biomolecular structure and dynamics, volume 17, issue 4, pp. 747-757
Jean-Yves PAQUET, Carlota VINALS BASSOLS, Johan WOUTERS, Jean-Jacques LETESSON, Eric DEPIEREUX
1999
Structure and Function Prediction of the Brucella abortus P39 Protein by Comparative Modeling with Marginal Sequence Similarities, in Protein Engeneering, volume 12, issue 3, pp. 217-223
Katalin DE FAYS, Anne TIBOR, Christophe LAMBERT, Carlota VINALS BASSOLS, Philippe DENOEL, Xavier DE BOLLE, Johan WOUTERS, Jean-Jacques LETESSON, Eric DEPIEREUX
1999
A reversible monoamine oxidase a inhibitor, befloxatone: structural approach of its mechanism of action, in Bioorganic and medicinal chemistry, issue 7, pp. 1683-1693
Johan WOUTERS, Florence MOUREAU, Guy EVRARD, Jean-Jacques KOENIG, Samir JEGHAM, Pascal GEORGE, François DURANT
1999
Lys13 plays a crucial role in the functional adaptation of the thermophilic triose-phosphate isomerase from Bacillus stearothermophilus to high temperatures., in J Biol Chem, volume 274, issue 27, pp. 19181-19187
Marco ALVAREZ, Johan WOUTERS, Dominique MAES, Veronique MAINFROID, Françoise RENTIER-DELRUE, Lode WYNS, Eric DEPIEREUX, Joseph A. MARTIAL
1999
5-substituted pyrimidine 1,5-anhydrohexitols: conformational analysis and interaction with viral thymidine kinase, in Bioorganic and medicinal chemistry letters, issue 9, pp. 1563-1566
Johan WOUTERS, Piet HERDEWIJN
1999
Antagonism of the TXA2 receptor by seratrodast: a structural approach, in Bioorganic and Medicinal Chemistry Letters, volume 9, pp. 2867-2870
Johan WOUTERS, François DURANT, Bernard MASEREEL
1998
Design, Synthesis and Anticonvulsant Activity of 1-(Pyrid-3-ylsulfonamido)-2-nitroethylenes, in Journal of Medicinal Chemistry, volume 41, issue 17, pp. 3239-3244
Bernard MASEREEL, Johan WOUTERS, Lionel POCHET, Didier LAMBERT
1998
Molecular lipophilicity potential by clip, a reliable tool for the description of the 3D distribution of lipophilicity: application to 3-phenyloxazolidin-2-one, a prototype series of reversible MAOa inhibitors, in Bioorganic and medicinal chemistry letters, volume 8, pp. 1425-1430
Frédéric OOMS, Johan WOUTERS, Sonia COLLIN, François DURANT, Samir JEGHAM, Pascal GEORGE
1998
Cis-4,6-Dimethyl-2-phenyl-1,3-diselenane, in Acta Cristallographica C, volume 54, pp. 1505-1507
Guy BAUDOUX, Bernadette NORBERG, Johan WOUTERS, Laurent DEFRERE, Alain KRIEF, Guy EVRARD
1998
Mutagenesis of the fructose-6-phosphate-binding site in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.: Bertrand, L., Vertommen, D., Freeman, P.M., Wouters, J., Depiereux, E., Di Pietro, A., Hue, L. and Rider, M.H. (19
Luc BERTRAND, VERTOMMEN, FREEMAN, Johan WOUTERS, Eric DEPIEREUX, DI PIETRO, Louis HUE, RIDER
1998
First partial three-dimensional model of human monoamine oxidase A, in Proteins, issue 32, pp. 97-110
Johan WOUTERS, Guy BAUDOUX
1998
Cis-4,6-Dimethyl-2-phenyl-1,3-diselenane, in Acta crystallographica. Section C, issue 54, pp. 1505-1507
Guy BAUDOUX, Bernadette NORBERG, Johan WOUTERS, Laurent DEFRERE, Alain KRIEF, Guy EVRARD
1998
Cation-pi (Na+ - Trp) interactions in the crystal structure of tetragonal lysozyme, in Protein science, issue 7, pp. 2472-2475
Johan WOUTERS
1998
Structural aspects of monoamine oxidase and its reversible inhibition, in Current medicinal chemistry, issue 5, pp. 137-162
Johan WOUTERS
1997
2-Oxazolidinone, in Acta crystallographica. Section C, issue 53, pp. 895-897
Johan WOUTERS, Frédéric OOMS, François DURANT
1997
Reversible inhibition of type B monoamine oxidase: theoretical study of model diazo heterocylic compounds, in European journal of medicinal chemistry, issue 32, pp. 721-730
Johan WOUTERS, Frédéric OOMS, S. JEGHAM, J. J. KOENIG, Pascal GEORGE, François DURANT
1997
Electronic properties of flavins: inplications on the reactivy and absorbtion properties of flavoproteins, in International journal of quantum chemistry , volume 64, pp. 721-733
Johan WOUTERS, François DURANT, Benoît CHAMPAGNE, Jean-Marie ANDRÉ
1997
The dipeptide pGlu-Pro-NH2, in Acta crystallographica. Section C, issue 53, pp. 477-480
Johan WOUTERS, Bernadette NORBERG, Guy EVRARD
1997
Conformational distribution of the potentially neurotoxic metabolite of haloperidol, HPP+, by NMR spectroscopy, X-ray crystallography and molecular dynamics simulations, in Journal of the Chemical society. Perkin transactions. 2, pp. 2627-2632
Frédéric OOMS, Johan WOUTERS, François DURANT, Neal CASTAGNOLI JR., Clinton VAN'T LAND, Gisella DOCKENDOLF, Thomas GLASS, "Cornelis J;" VAN DER SCHYF
1997
Trans- and cis-S-C-C-S conformations in 5-(2,2'-Dithien-5-yl)-2'-deoxyuridine, in Acta crystallographica. Section C, issue 53, pp. 892-895
Johan WOUTERS, I. CREUVEN, Bernadette NORBERG, Guy EVRARD, François DURANT, A. VAN AERSCHOT, P. HERDEWIJN
1997
Molecular structures of the free base and hydrochloride forms of 7-methoxy-1-9H-pyrido(3,4-B)indole (Harmine), in Bulletin de la société chimique de Belgique, volume 106, issue 12, pp. 759-766
Johan WOUTERS
1996
6-Bromo-2H-3,1-benzoxazine-2,4(1H)-dione at 153 K, in Acta crystallographica. Section C, issue 52, pp. 3108-3110
Paolo LUBINI, Johan WOUTERS
1996
TAPSO at low temperature, in Acta crystallographica. Section C, issue 52, pp. 1684-1686
Johan WOUTERS, Dietmar STALKE
1996
HEPES, in Acta crystallographica. Section C, issue 52, pp. 1687-1688
Johan WOUTERS, Ludger HÄMING, George SHELDRICK
1996
An MPP+ analog: the 2:1 N-cyclopentyl- 4-phenylpyridinium bromide-4-phenyl-pyridine complex, in Acta crystallographica. Section C, issue 52, pp. 1033-1036
Johan WOUTERS, Guy EVRARD, François DURANT, Amit KALGUTKAR, Neal CASTAGNOLI JR
1995
A Reversible Monoamine Oxidase Inhibitor, Toloxatone: Comparison of its Physico-Chemical Properties with those of other Inhibitors Including Brofaromine, Harmine and R40519, in J. Pharm. Belg., volume 50, pp. 269-269
Florence MOUREAU, Johan WOUTERS, Murielle DEPAS, Daniel VERCAUTEREN, François DURANT, Fiona DUCREY, Jean-Jacques KOENIG, François-Xavier JARREAU
1995
A Reversible Monoamine Oxidase Inhibitor, Toloxatone: Comparison of its Physicochemical Properties with those of other Inhibitors Including Brofaromine, Harmine, R40519 and Moclobemide, in Eur. J. Med. Chem., volume 30, pp. 823-838
Florence MOUREAU, Johan WOUTERS, Murielle DEPAS, Daniel VERCAUTEREN, François DURANT, Fiona DUCREY, Jean-Jacques KOENIG, François-Xavier JARREAU
1995
Secondary structure of monoamine oxidase by FTIR spectroscopy, in Biochemical and biophysical research communications, volume 208, issue 2, pp. 773-778
Johan WOUTERS, R. RAMSAY, E. GOORMAGHTIGH, J.-M. RUYSSCHAERT, R. BRASSEUR, François DURANT
1995
Cristallographie à résolution temporelle (time-resolved crystallography), in Chimie nouvelle, volume 13, issue 50, pp. 1461-1468
Johan WOUTERS
1995
Lumiflavinium (7,8,10-trimethyl-isoalloxazinium) nitrate, in Acta crystallographica. Section C, issue 51, pp. 1223-1227
Johan WOUTERS, Guy EVRARD, François DURANT
1994
The molecular structure of caroxazone, a reversible monoamine oxidase inhibitor, in Acta crystallographica. Section C, issue 50, pp. 1774-1777
Johan WOUTERS, Guy EVRARD, François DURANT
1994
Structure analysis of monoamine oxidase inhibitors, (R)-5-hydroxymethyl- and (R)-5-methoxymethyl-3-(4-methoxyphenyl)-oxazolidin-2-one, in Acta crystallographica. SectionC, issue 50, pp. 97-100
Johan WOUTERS, Philippe PERPÈTE, Bernadette NORBERG, Guy EVRARD, François DURANT
1994
Structural characterization of oxidized lumiflavin hydrochloride hydrate: comparison with the hydrogen bonding at the cofactor of flavoproteins, in Journal of chemical crystallography, volume 24, issue 9, pp. 607-614
Johan WOUTERS, Florence MOUREAU, philippe PERPETE, Bernadette NORBERG, Guy EVRARD, François DURANT
1994
Structure analysis of a reversible monoamine oxidase A inhibitor: 3-{4-[(R)-3-hydroxybutoxy]phenyl}-(R)-5-methoxymethyl-1,3-oxazolidin-2-one, in Acta crystallographica. Section C, issue 50, pp. 1490-1492
Johan WOUTERS, Guy EVRARD, François DURANT
1994
Experimental and Theoretical Study of Reversible Monoamine Oxidase Inhibitors: Structural Approach of the Active Site of the Enzyme, in J. Neural Transm., volume 41, pp. 313-319
Johan WOUTERS, Florence MOUREAU, Daniel VERCAUTEREN, Guy EVRARD, François DURANT, Jean-Jacques KOENIG, Fiona DUCREY, François-Xavier JARREAU
1994
A Reversible Monoamine Oxidase Inhibitor, Toloxatone: Spectrophotometric and Molecular Orbital Studies of the Interaction with Flavin Adenine Dinucleotide (FAD), in Eur. J. Med. Chem., volume 29, pp. 269-277
Florence MOUREAU, Johan WOUTERS, Daniel VERCAUTEREN, Sonia COLLIN, Guy EVRARD, François DURANT, Fiona DUCREY, Jean-Jacques KOENIG, François-Xavier JARREAU
1994
Kinetic characterization of tyramine oxydase of arthrobacter species, in Biochemistry and molecular biology international, volume 32, issue 4, pp. 737-743
Johan WOUTERS, P. PERPÈTE, Pierre HAYEN, N. ANCEAU, François DURANT
1993
Molecular structure analysis of moclobemide, a monoamine oxidase inhibitor, in Bulletin de la Société chimique de Belgique, volume 102, issue 5, pp. 329-333
Johan WOUTERS, Florence MOUREAU, Bernadette NORBERG, Guy EVRARD, François DURANT
1992
A Reversible Monoamine Oxidase Inhibitor, Toloxatone: Structural and Electronic Properties, in Eur. J. Med. Chem., volume 27, pp. 939-948
Florence MOUREAU, Johan WOUTERS, Daniel VERCAUTEREN, Sonia COLLIN, Guy EVRARD, François DURANT, Fiona DUCREY, Jean-Jacques KOENIG, François-Xavier JARREAU

Actes de colloques

2011
THIOSEMICARBAZONES AS INHIBITORS OF TRYPTOPHAN 2,3-DIOXYGENASE (TDO), AN EMERGING TARGET FOR CANCER TREATMENT, in Book of Abstracts, Emerging Targets and Treatments: Opportunities and Challenges for Drug Design, Ghent, 25 November 2011, volume P21
Eduard DOLUSIC, Sara MODAFFARI, Pierre LARRIEU, Christelle VANCRAEYNEST, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Benoît VAN DEN EYNDE, Johan WOUTERS, Bernard MASEREEL, Raphael FRÉDÉRICK
2011
Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy., in Book of Abstracts, Emerging Targets and Treatments: Opportunities and Challenges for Drug Design, Ghent, 25 November 2011, volume P22
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Paulette CHARLIER, Sophie LAURENT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2011
SYNTHESIS, ACTIVITY, CRYSTAL AND ELECTRONIC PROPERTIES OF ISOMERS OF CHLORO-PYRIDINYLVINYL-1H-INDOLES, in Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, volume P20, pp. 45-45
Laurence MOINEAUX, Sophie LAURENT, Eduard DOLUSIC, Jérémy RENIERS, Bernadette NORBERG, Jean-Marie FRÈRE, Moreno GALLENI, Benoît VAN DEN EYNDE, Bernard MASEREEL, Raphael FRÉDÉRICK, Johan WOUTERS
2011
Novel Inhibitors of Indoleamine 2,3-Dioxygenase (IDO), a Target for Anti-Cancer Immunotherapy, in Book of Abstracts, XVIIIème Journée Jeunes Chercheurs, 04/02/11, Paris, France
Eduard DOLUSIC, Sébastien BLANC, Pierre LARRIEU, Laurence MOINEAUX, Delphine COLETTE, Graeme FRASER, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Johan WOUTERS, Bernard MASEREEL, Benoît VAN DEN EYNDE, Raphael FRÉDÉRICK
2011
A CONVENIENT FORMATION OF HIGHLY FUNCTIONALIZED 5-BROMO-1,3-THIAZOLES., in Book of Abstracts, 15th Sigma-Aldrich Organic Synthesis Meeting, Spa, Belgium, 1-2 December 2011, pp. 25-25
Eduard DOLUSIC, Sara MODAFFARI, Johan WOUTERS, Bernard MASEREEL, Raphael FRÉDÉRICK
2011
AROMATIC THIOSEMICARBAZONES ARE INHIBITORS OF TRYPTOPHAN 2,3-DIOXYGENASE (TDO), AN EMERGING TARGET FOR CANCER TREATMENT, in Book of Abstracts, 4th International Symposium on Advances in Synthetic and Medicinal Chemistry (ASMC 11), St. Petersburg, Russia, August 21-25, 2011, volume P157, pp. 270-270
Eduard DOLUSIC, Sara MODAFFARI, Pierre LARRIEU, Christelle VANCRAEYNEST, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Johan WOUTERS, Bernard MASEREEL, Benoît VAN DEN EYNDE, Raphael FRÉDÉRICK
2011
Discovery and preliminary SARs of new scaffolds of tryptophan 2,3-dioxygenase (TDO) inhibitors using virtual screening, in Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, volume P19, pp. 44-44
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2011
Indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2,3-dioxygenase (IDO), a promising target for anti-cancer immunotherapy, in Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, volume P37, pp. 62-62
Eduard DOLUSIC, Pierre LARRIEU, Sébastien BLANC, Laurence MOINEAUX, Delphine COLETTE, Graeme FRASER, Vincent STROOBANT, Luc PILOTTE, Didier COLAUX, Johan WOUTERS, Bernard MASEREEL, Benoît VAN DEN EYNDE, Raphael FRÉDÉRICK
2011
LECTURE: Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A, in Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, volume OC10, pp. 22-22
Eduard DOLUSIC, Pierre LARRIEU, Delphine COLETTE, Sébastien BLANC, Arnaud RIVES, Graeme FRASER, Johan WOUTERS, Robert KISS, Benoît VAN DEN EYNDE, Bernard MASEREEL, Evelyne DELFOURNE, Raphael FRÉDÉRICK
2011
Indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2,3- dioxygenase (IDO), a promising target for anti-cancer immunotherapy, in Book of Abstracts, 47èmes RICT, 6-8 juillet 2011, Lyon, France, volume IS08, pp. 136-136
Eduard DOLUSIC, Pierre LARRIEU, Sébastien BLANC, Laurence MOINEAUX, Frédéric SAPUNARIC, Jenny POUYEZ, Delphine COLETTE, Graeme FRASER, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Jean-Marie FRÈRE, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2011
coauthor on lecture: Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase (TDO): discovery of an orally active TDO inhibitor., in Book of Abstracts, Emerging Targets and Treatments: Opportunities and Challenges for Drug Design, Ghent, 25 November 2011, volume OC01
Eduard DOLUSIC, Pierre LARRIEU, Laurence MOINEAUX, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Benoît VAN DEN EYNDE, Bernard MASEREEL, Johan WOUTERS, Raphael FRÉDÉRICK
2010
Synthesis, crystal and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles, in Abstracts, The sixth Belgian Crystallography Symposium (BCS-6), 13 October 2010, Brussels, Belgium
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2010
Tryptophan 2,3-dioxygenase (TDO) inhibitors : Identification of new scaffolds using virtual screening, in Abstracts, Journée scientifique de la Société royale de chimie (SRC), Gembloux, Belgium, 14 October 2010
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2010
Conception, synthèse et étude d'inhibiteurs de la tryptophane 2,3-dioxygénase (TDO), une cible prometteuse pour le traitement du cancer, in Abstracts, Séminaire des jeunes chercheurs Télévie 2011, Brussels, Belgium, 7 December 2010
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2010
Indole-pyridinyl-ethanones as Novel Inhibitors of Indoleamine 2,3-Dioxygenase (IDO), a Promising Target for Anti-Cancer Immunotherapy, in Book of Abstracts, XXIVth European Colloquium on Heterocyclic Chemistry, Vienna, Austria, August 23-27, 2010, pp. PO-41
Eduard DOLUSIC, Sébastien BLANC, Pierre LARRIEU, Laurence MOINEAUX, Delphine COLETTE, Graeme FRASER, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Johan WOUTERS, Bernard MASEREEL, Benoît VAN DEN EYNDE, Raphael FRÉDÉRICK
2008
Application of the boron neutron capture therapy to the carbonic anhydrase IX, in Abstract book - XIII International Conference on Boron Chemistry, pp. P014
Julien DEGLIM, Anne THIRY, Johan WOUTERS, Bernard MASEREEL
2007
Inhibiteurs d'anhydrases carboniques. Evaluation de l'effet anticonvulsivant d'indanesulfonamides, in Abstract Book-21èmes Journées Franco-Belges de Pharmacochimie
Anne THIRY, Aurélie FRANKART, Catherine MICHAUX, Jean-Michel DOGNÉ, Claudiu T. SUPURAN, Johan WOUTERS, Bernard MASEREEL
2007
Towards new leads for selective carbonic anhydrase IX inhibition: synthesis, pharmacological evaluation and combined ligand-based and target-based approach, in Abstract Book-New Drugs and Drug Candidates : Recent Achievements in Medicinal Chemistry
Anne THIRY, Marie LEDECQ, Jean-Michel DOGNÉ, Claudiu T. SUPURAB, Johan WOUTERS, Bernard MASEREEL
2007
Étude structurale de l'inhibition du facteur XII et de la thrombine, protéases à sérine plasmatiques, in Abstract book of 21èmes Journées Franco-Belges de Pharmacochimie
Catherine MICHAUX, Marie DEL TEDESCO, Severine ROBERT, Lionel POCHET, Johan WOUTERS
2007
Carbonic anhydrase inhibitors: synthesis, biological evaluation and rational drug design to target the tumor-associated CA IX, in Abstract Book-13th Belgian Forum of Pharmaceutical Sciences
Anne THIRY, Marie LEDECQ, Jean-Michel DOGNÉ, claudiu T. SUPURAN, Johan WOUTERS, Bernard MASEREEL
2007
Application of the boron neutron capture therapy to the carbonic anhydrases, in Abstract Book-13th Belgian Forum of Pharmaceutical Sciences
Julien DEGLIM, Anne THIRY, Johan WOUTERS, Bernard MASEREEL
2005
Developpement d'indanesulfonamides inhibiteurs de l'anhydrase carbonique IX, in Abstract Book-19èmes Journées Franco-Belge de pharmacochimie
Anne THIRY, Marie LEDECQ, Celine CHAZALETTE, Johan WOUTERS, Claudiu T. SUPURAN, Bernard MASEREEL
2001
Towards new leads for selective cyclooxygenase-2 (COX-2) inhibition, in Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie, pp. 84
Catherine MICHAUX, Stéphanie ROLIN, Xavier DE LEVAL, Bernard MASEREEL, François DURANT, Johan WOUTERS

Comptes rendus scientifiques

2010
STRUCTURAL AND ENZYMATIC STUDY OF TRYPTOPHAN 2,3- DIOXYGENASE (TDO), A POTENTIAL TARGET IN ANTICANCER IMMUNOTHERAPY, in Drugs of the Future, volume 35, issue suppl. A, pp. 217-218
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2010
Discovery and Optimization Of Indole-pyridinyl-ethanones as Novel Inhibitors of Indoleamine-2,3-Dioxygenase (IDO), a Promising Target for Anti-Cancer Immunotherapy, in Drugs of the Future, volume 35, issue suppl. A, pp. 181-182
Raphael FRÉDÉRICK, Sébastien BLANC, Pierre LARRIEU, Laurence MOINEAUX, Delphine COLETTE, Graeme FRASER, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Johan WOUTERS, Bernard MASEREEL, Benoît VAN DEN EYNDE, Eduard DOLUSIC
2008
Towards new leads for selective carbonic anhydrase IX inhibition: synthesis, pharmacologcal evaluation and combined ligand-based and target-based approach., in Chimie Nouvelle, volume 98, pp. 26-26
Anne THIRY, Marie LEDECQ, Jean-Michel DOGNÉ, Claudiu SUPURAN, Johan WOUTERS, Bernard MASEREEL
2006
Design, synthesis and biological evaluation of indanesulfonamides as carbonic anhydrase IX inhibitors, in Fundamental and Clinical Pharmacology, volume 20, pp. 626
Anne THIRY, Marie LEDECQ, Alessandro CECCHI, Jean-Michel DOGNÉ, Johan WOUTERS, Claudiu T. SUPURAN, Bernard MASEREEL
2006
Indanesulfonamides as carbonic anhydrase inhibitors, in Drugs of the Future, volume 31, issue A, pp. 84
Anne THIRY, Marie LEDECQ, Alessandro CECCHI, Jean-Michel DOGNÉ, Johan WOUTERS, Claudiu T. SUPURAN, Bernard MASEREEL
2001
Pharmacological evaluation of original sulfonylureas as thromboxane A2 antagonists, in Fundamental and Clinical Pharmacology, volume 300, pp. 14
Jean-Michel DOGNÉ, Xavier DE LEVAL, Philippe NEVEN, Fabian SOMERS, Jacques DELARGE, Stéphanie ROLIN, Catherine MICHAUX, Johan WOUTERS, Bernard PIROTTE, Jacques DAMAS, Bernard MASEREEL
2000
Pharmacological evaluation of original sulfonylureas as thromboxane A2 antagonists, in Fundamental and clinical Pharmacology, volume 14, pp. 300
Jean-Michel DOGNÉ, Xavier DE LEVAL, Philippe NEVEN, Fabian SOMERS, Jacques DELARGE, Stéphanie ROLIN, Catherine MICHAUX, Johan WOUTERS, Bernard PIROTTE, Jacques DAMAS, Bernard MASEREEL
1999
Classification of family G xylanases based on primary structure analysis using the Match-Box program and a proposed 3D structure for a xylanase sequenced from Penicilium purpurogenum, Archives of Physiology and Biochemistry, 107:B5
DE IOANNES, SAPAG, EYZAGUIRRE, Christophe LAMBERT, Eric DEPIEREUX, Johan WOUTERS
1999
Classification of family G xylanases based on primary structure analysis using the Match-Box program and a proposed 3D structure for a xylanase sequenced from Penicilium purpurogenum, Archives of Physiology and Biochemistry, 107:B5
DE IOANNES, SAPAG, EYZAGUIRRE, Christophe LAMBERT, Eric DEPIEREUX, Johan WOUTERS

Thèses

1995
Caractérisation structurale et électronique d'inhibiteurs réversibles de la monoamine oxydase: modélisation de leur interaction avec l'enzyme
Johan WOUTERS

Mémoires

1991
Etude d'inhibiteurs de la monoamine oxydase: interaction avec le cofacteur flavinique de l'enzyme
Johan WOUTERS

Mémoires et thèses supervisés (33)

Articles de périodique

2011
Rational design, synthesis, molecular modeling and evaluation of b-carbolines and 5H-indeno[1,2-c]pyridazin-5-one derivatives as potential MAO and IDO inhibitors
Jérémy RENIERS

Actes de colloques

2010
Design, synthesis and study of inhibitors of tryptophan 2,3-dioxygenase (TDO), a promising target for cancer therapy, in Abstracts, école doctorale Structure et Fonction des Macromolécules Biologiques, Bioinformatique et Modélisation (SFMBBM), Liège, Belgium, 10 December 2010
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Raphael FRÉDÉRICK

Comptes rendus scientifiques

2007
Structure of Thermus thermophilus type 2 isopentenyl diphosphate isomerase inferred from crystallography and molecular dynamics
Jerome DE RUYCK, Jenny POUYEZ, Steven C. ROTHMAN, C. Dale POULTER

Thèses

2011
Rational design, synthesis, molecular modeling and evaluation of Β-carboline and 5H-indeno[1,2-c]pyridazin-5-one derivatives as potential MAO and IDO inhibitors
Jérémy RENIERS
2011
Structural study of HIV-1 integrase inhibition by quinolones: contribution to the rational design of new inhibitors
Pierre VANDURM
2010
Le rôle des microémulsions dans le transport des médicaments à travers la peau : étude du rétinol et de l'ibuprofène
Caroline DESTREE
2008
Etude structurale comparative des Isopentenyl Diphosphate Isomérases de type 1 et 2
Jerome DE RUYCK
2006
Caractérisation structurale de la 5-lipoxygénase humaine et de son inhibition: support à la conception rationnelle d'inhibiteurs mixtes 5-LOX-COX-2
Caroline CHARLIER
2000
Rational approach of the reversible inhibition of type A and B MAO: design and synthesis of original 5H-indeno[1,2-c]pyridazin-5-one derivatives
Frédéric OOMS

Mémoires

2012
Etude de l'inhibition de l'ADN (cytosine-5) méthyltransférase bactérienne M.HhaI par un inhibiteur non-nucléosidique, dérivé du RG108.: Mémoire présenté pour l'obtention du grade académique de Master en Sciences Chimiques "Chimie du Vivant et des Nanomatériaux" : Finalité Approfondie.
Grégoire RONDELET, Caroline CHARLIER
2012
Etude de l'inhibition de l'ADN (cytosine-5) méthyltransférase bactérienne M.HhaI par un inhibiteur non-nucléosidique, dérivé du RG108.: Mémoire présenté pour l'obtention du grade académique de Master en Sciences Chimiques "Chimie du Vivant et des Nanomatériaux" : Finalité Approfondie.
Grégoire RONDELET
2012
Etude de l'inhibition de la 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) d'E. coli.: Mémoire présenté pour l'obtention du grade académique de Master en Sciences Chimiques "Chimie du Vivant et des Nanomatériaux" : Finalité Approfondie.
Anne-Sylvie CHAPELLE
2012
Caractérisation enzymatique et structurale d'inhibiteurs indoliques de la tryptophane 2,3-dioxygénase.: Mémoire présenté pour l'obtention du grade académique de Master en Chimie "Chimie du Vivant et des Nanomatériaux" : Finalité Spécialisée.
Noémie MOLLE
2011
Etude structurale et enzymatique de l'indoléamine 2,3-dioxygénase
Céline MEINGUET
2010
Etude de l'inhibition des ADN (cytosine-5) méthyltransférases par le RG108, un inhibiteur non-nucléosidique
Isabelle BOUHY
2010
Etude de la complexation de dérivés quinolone par des cations métalliques divalents: contribution à l'étude de mode d'inhibition de l'intégrase du VIH-1
Denis BURTON
2010
Etude structurale et enzymologique de l'α-isopropylmalate synthase de Mycobacterium tuberculosis en vue de l'identification d'inhibiteurs
Julie DELCHAMBRE
2008
Cristallisation, obtention et caractérisation de structures cristallines stables du Piracetam et de plusieurs de ses analogues
Anaëlle TILBORG
2007
Etude structurale du mode d'inhibition du facteur XII, impliqué dans la cascade de la coagulation, par des dérivés coumariniques
Marie DEL TEDESCO
2007
Etude expérimentale de l'uridine diphosphate-galactopyranose mutase et de deux mutants ponctuels
Sophie LAURENT
2007
Structures et propriétés physico-chimiques de colorants, isomères de l'alizarine
Laurence MOINEAUX
2007
Conception d'inhibiteurs de l'intégrase du VIH-1 dérivés du cycle quinolone
Pierre VANDURM
2007
Etude structurale de l'isopentényl diphosphate isomérase de type 2 (IDI 2) de Streptococcus pneumoniae en vue d'identifier de nouveaux agents anti-infectieux
Caroline ROSART
2006
Etude expérimentale et théorique du mode d'interaction de l'enzyme bactérienne UDP-galactopyranose mutase avec des analogues non-isomérisables des substrats
Ludivine GENON
2006
Etude structurale de la 1-déoxy-D-xylulose-5-phosphate réductoisomérase (DXR) en vue de rationaliser l'activité d'analogues de la fosmidomycine
Maureen FAMERÉE
2006
Etude de l'inhibition des ADN (cytosine-5) méthyltransférases par une série d'analogues du RG108
Julie BRAUN
2005
Approche structurale de l'inhibition de la Fatty acid amide hydrolase humaine
Catherine WESPES
2005
Etude structurale du complexe ß-cyclodextrine/aspartame
Virginie LAMBERT
2005
Etude structurale du mode d'interaction de l'enzyme bactérienne UDP-galactopyranose mutase avec ses substrats
Sébastien GODFROID
1999
Les protéases à sérine: contribution à l'étude du mécanisme d'inhibition de la chymotrypsine par des dérivés de type coumarinique
Marjorie HUYGENS
1999
Analyse structurale et électronique au moyen de méthodes physico-chimiques expérimentales et théoriques de l'interaction entre le récepteur du thromboxane et ses antagonistes
Catherine MICHAUX
1998
Modélisation de la monoamine Oxydase de type B
Fanny LIÉGEOIS
1993
Etude structurale de deux inhibiteurs de la monoamine oxydase de type B: interactions possibles avec le site actif de l'enzyme
Nathalie ANCEAU