Membre du personnel

Olivier TOUSSAINT

Téléphone: 081/724132
Fax: 081/724135
Mail:

Charges aux FUNDP

Unité de recherche en biologie cellulaire (Chercheur qualifié FNRS)
NAmur Research Institute for LIfe Sciences (Scientifique)
Conseil de la faculté des sciences (Membre)
Groupe de recherche "personnes agées" (Scientifique)

Diplômes

Docteur (avec thèse)

Activités avec contribution

Conférence : 12th World Congress on Cancers of the Skin. (Tel Aviv, Israel, 2009)

Development of full-thickness human skin cultures to investigate dermal and epidermal photo-ageing in a 3D model. Dedessus le Moutier, Salmon, Belot, Seltmann, Zouboulis, Toussaint.

Conférence : LINK-AGE workshop on skin ageing (thematic group B) (Noordwijkerhout, The Netherlands, 2008)

Development of full-thickness human skin cultures to investigate fibroblasts/keratinocytes interaction in a in vitro 3D model.

Dedessus le Moutier, Salmon, Belot, Seltmann, Zouboulis, Toussaint.

Conférence : 1rst skin physiology international meeting. (Vichy, France, 2008)

UVB-Stress Induced Premature Senescence as a simplified model of dermal ageing.Chainiaux & Toussaint.

Conférence : International conference on safe production and use of nanomaterials. (Grenoble, France, 2008)

Nanotoxico: Toxicological assessment of manufactured nanomaterials using in vitro and vivo models. Saout, Vankoningsloo, Piret, Marijsse, Noël, Rolin, Laloy, Masereel, Mendoza, Lucas & Toussaint.

Colloque : Extracts of the polynesian plant microsorum scolopendria as new anti-aging cosmetic active ingredients. Meybeck, Bernard, Pedretti, Salmon, Belot, Toussaint, Ho & Raharivelomanana - 25th IFSCC Congress (Barcelona, Spain, 2008)

Colloque : The pro-Vitamin D sterols 7-dehydrocholesterol and ergosterol can activate p53 and lower the incidence of senescent skin fibroblasts. Meybeck, Belot, Salmon, Juchaux, Bernard, Wurtz, Moras & Toussaint - 25th IFSCC Congress (Barcelona, Spain, 2008)

Colloque : Nanotoxico: Toxicological assessment of engineered nanoparticles using in vitro and in vivo models. Rolin, Laloy, Masereel, Vankoningsloo, Piret, Lucas, Saout & Toussaint au Nanotech Northern Europe 2008 (Copenhagen, Denmark, 2008)

Colloque : MEcdysteroids from plants prevent uv induced premature senescence of human skin fibroblasts. eybeck A, Yang C-R, Zhang Y-J, Salmon M, Belot N, Toussaint O, Wurtz J-M, Moras D, Ho R & Raharivelomanana P - XVIIth International Ecdysone Workshop (Ulm, Germany , 2008)

Réunion : Nanotoxico : In vitro model development for the toxicity assessment of manufactured nanomaterials. Vankoningsloo, Piret, Deglas, Lambinon, Vigneron, Lucas & Toussaint. Annual Meeting '07, The Belgian Society for Toxicology & Ecotoxicology (Namur, FUNDP, 2007)

Colloque : Long term DNA damage in premature senescence induced by UVB. IBMC fall symposium : The free radical theory : 50 years and beyond. Debacq-Chainiaux, Borlon, Deglas, Ninane, de Longueville, Remacle & Toussaint (Porto, Portugal, 2007)

Colloque : Nanotoxico: In vitro model development for nanomaterial toxicity assessment on human health. Vankoningsloo & Toussaint - 14th Congress on Alternatives to Animal Testing (Linz, Austria, 2007)

Colloque : UV-induced premature senescence of human skin fibroblasts as an in vitro model for the development of anti-photoageing cosmetic products- 20-hydroxyecdysone, a new ingredient that prevents photageing. Belot,Leroy,Bastin,Yang,Zhang,Toussaint, Meybeck (Saint-Malo, France, 2007)

Conférence : Use of bioplex technology in the characterization of immunosenescence involvement in the frailty syndrome. Martens, Morrhaye, Bruck, de St-Hubert, Weemaels, Simul, Schaaf-lafontaine, Swine, Toussaint, Geenen. Cytometrie 2006. (Bruges, Oud St-Jan, 2006)

Colloque : 20-hydroxyecdysone, a new ingredient to repair fibroblast damage caused by UV light in order toprevent their premature senescence. Meybeck, Chong-Ren, Toussaint, Belot & Salmon. 24th IFSCC congress (Osaka, Japan, 2006)

Conférence : Symposium on aging research in immunology. First characterization of immunosenescence involvement in the frailty syndrome - Morrhaye, de St-Hubert, Weemaels, Swine, Toussaint, Geenen & Martens. (Paris, France, 2006)

Colloque : Nanotoxico: Risk assessment of nanoparticles on human health using in vitro and in vivo models. Piret, Vankoningsloo, Vigneron, Rolin, Saout, Masereel, Delhalle, Lucas & Toussaint - 4th Int. congress of nanotechnology & clean tech (San Francisco, USA, 0008)

Réunion : Comparison of genes expression during replicative senescence and stress-induced premature senescence of human diploid fibroblasts. The Rank Prize Funds - Mini symposium on caloric restriction and ageing- Pascal, Bastin, Remacle & Toussaint. (Grasmere, UK, 0004)

Réunion : The Rank Prize Funds - Mini symposium on caloric restriction and ageing. TGF-beta 1 and clusterin in UVB-induced premature senescence - Debacq-Chainiaux, Borlon, Wenders, Eliaers, Remacle & Toussaint. (Grasmere, UK, 0004)

Activités : conférencier

Colloque : Nanotox Cluster European Commission (Brussels, Belgium, 2009)
Colloque : ERA-AGE (Brussels, Belgium, 2009): The future of ageing research in Europe, designing the road map for ageing research : Biology/ Biomedicine. European Economùic and social Comitee.
Colloque : Annual Meeting, French Society for Cosmetology (Paris, France, 2008): Stress-induced premature senescence : from cell biology to technological platforms
Colloque : 6th European Congress of Biogerontology (Leiden, The Netherlands, 2008): Role of IGFBPs in t-BHP, ethanol and UVB-induced premature senescence
Séminaire : LINK-AGE workshop on Model systems (Noordwijkerhout, The Netherlands, 2008): Stress-induced premature senescence of human fibroblasts. Role of TGF-beta1 and cdc 42
Séminaire : Sysbiohealth symposium. (Bologna, Italy, 2008): Medicine and disease : a systems biology perspective. Far from equilibrium open systems also age. From a holistic view on ageing to systems biology in ageing
Réunion : Groupe de contact FNRS «nutrition, alimentation et santé ». 4ème symposium du GCNAS Aperçu des techniques de génomique et de protéomique applicables au secteur de la nutrition (Liège, 2008)
Conférence : ICT-BIO Conference (Brussels, 2008): Computer modelling and simulation for improving human health. From theorical modelling of ageing to mechanistic research and systems biology
Conférence : Cellular Senescence : the future of ageing? Stress-induced (premature) senescence or stress-induced senescence-like phenotype? Role of TGF-beta1 and cdc 42 (Oriel College, Oxford U.K., 2008)
Réunion : XIIth BELACT (Belgian Group for Animal Cell Technology) Meeting : 3D in vitro models: from nanotoxicology to drug delivery. NANOTOXICO : an interdisciplinary project from cell culture to rat (Namur, FUNDP, 2008)
Séminaire : IBMC fall symposium (Porto, Portugal, 2007): The free radical theory : 50 years and beyond. Stress-induced premature senescence, latest data
Réunion : Toussaint et Debacq-Chainiaux. Société Belge de Gériatrie et de Gérontologie. Résistance cellulaire au stress (Liège, 2007)
Séminaire : Tissue Ageing : from Molecular Biology to Clinical Perspectives (Halle-Wittenberg, Germany, 2007): Role of TGF-beta1 and cdc 42 in Stress-induced premature senescence. Halle-Wittenberg
Séminaire : Link-age / Mimage Summer School. (Les Diablerets, Switzerland, 2007): Biomarkers of senescence, signal transduction and proteomics in stress-induced premature senescence
Colloque : 12th Congress of the International Association of Biomedical Gerontology (IABG) (Island of Spetses, Greece, 2007)
Séminaire : SPARC/BCA Workshop (Birmingham, UK, 2007): Ageing research funding opportunities in EU FP7 programme. What makes a good framework application ?
Conférence : ECONAG : European Conference on Ageing. (Innsbruck, Austria, 2006)
Conférence : Gordon Conference, Biology of Aging (Ventura, Ca, USA, , 2006): Stress-induced premature senescence : role of IGBP-3
Colloque : 11th Congress of the International Association of Biomedical Gerontology (Aarhus, Denmark, 2005)
Colloque : 3rd World Congress of Nephrology (18th Congress of the International Society of Nephrology) (Singapore, 2005): Plenary Speaker. A system biology approach to understand human aging
Colloque : Congrès International 'Stress, douleur et souffrance' (Brussels, Belgium, 2005): Stress-induced premature senescence of conjunctive tissue cells
Conférence : Pharmacology and Ageing Conference, Royal Pharmaceutical Society (London, UK, 2005): Oxidative stress and ageing
Séminaire : European Forum of Population Ageing Research (Brussels, Belgium, 2004): The Future of Ageing Research in Europe, European Economic and Social Committee. The findings of Functionage.
Séminaire : Applied Functional Genomics (Aarhus, Denmark, 2004): Stress-induced premature senescence and some of the 'omics
Séminaire : Society for Free Radical Research (Europe). (Lodz, Poland, 2004): Biomarkers and molecular mechanisms of stress-induced premature senescence.
Séminaire : Symposium 'Phytochemicals and the Prevention of Disease'. (Reading, UK, 2004): "In vitro tools to evaluate the therapeutic efficacy of phytochemicals"
Réunion : Joint meeting Belgian Society for Biochemistry and Molecular Biology & FNRS contact group. Phénomènes oxydatifs et antioxydants. Stress-induced premature senescence : from in vitro models to likely role in human ageing (Liège, 2004)
Colloque : XXXIXth Congress of the Polish Biochemical Society. (Gdansk, Poland, 2003): Stress-induced premature senescence : the latest data.

Activités : poster

Colloque : Study of the mechanisms of cellular responses to copper and research of possible implications of copper in cell senescence. Boilan, Bonfitto & Toussaint. 6th European Congress of Biogerontology (Leiden, The Netherlands, 2008)
Colloque : PIXE analyses of rat's lung exposed to TiC nanoparticles. Lucas, Vigneron, Mendoz, Masereel, Lison & Toussaint. IBAF 2008 (Carcans, France, 2008)
Réunion : Study of the mechanisms of cellular responses to copper in a model of exposure of human WI-38 fibroblasts to copper. Research of possible implications of copper in cell senescence. Boilan, Bonfitto and Toussaint. 200th Meeting of the BSBS (Namur, FUNDP, 2008)
Colloque : Nanotoxico: Development of relevant models for toxicological studies on manufactured nanomaterials. Piret, Vankoningsloo, Deglas, Noël, Lambinon, Vigneron, Lucas, Saout & Toussaint. 15th International Congress on In Vitro Toxicology. Stockholm (Stockholm, Sweden, 2008)
Réunion : 3D in vitro models: from "nanotoxicology to "drug delivery". Development of full-thickness human skin cultures to investigate dermal and epidermal photo-ageing in a 3D model. Dedessus,Salmon,Belot,Seltmann,Zouboulis & Toussaint. XIIth BELACT (Namur, FUNDP, 2008)
Réunion : 3D in vitro models: from nanotoxicology to "drug delivery. Identification of intestinal inflammation biomarkers in human Caco-2 cells using TaqMan Low Density Array. Piront, Sergent, Chainiaux, Schneider & Toussaint. XIIth BELACT (Namur, FUNDP, 2008)
Réunion : 3D in vitro models: from "nanotoxicology to "drug delivery". Development of relevant models for toxicological assessment of manufactured nanomaterials. Vankoningsloo,Piret,Marijsse,Saout,Deglas,Noël,Lambinon,Vigneron,Lucas & Toussaint. XIIth BELACT (Namur, FUNDP, 2008)
Réunion : 3D in vitro models: from "nanotoxicology to "drug delivery". The effect of copper sulfate on human fibroblasts : stress-induced premature senescence. 4. Boilan, Chainiaux-Debacq, Matos & Toussaint. XIIth BELACT (Namur, FUNDP, 2008)
Colloque : The effect of copper sulfate on human fibroblasts : stress-induced premature senescence. Boilan, Chainiaux-Debacq, Matos, Osiewacz & Toussaint. IBMC fall symposium (Porto, Portugal, 2007)
Colloque : Development and characterization of full-thickness human skin cultures to investigate skin photo-ageing in a 3D model. Dedessus le Moutier, Salmon, Belot, Seltmann, Zouboulis & Toussaint. IBMC fall symposium (Porto, Portugal, 2007)
Réunion : 11th Bioforum of Ulg. Involvement of immunosenescence in frailty. 6. Morrhaye, Bruck, Saint-Hubert, Weemaels, Swine, Toussaint, Geenen & Martens. (Liège, 2007)
Réunion : UV-induced premature senescence of human skin fibroblasts as an in vitro model for the development of 20-hydroxyecdysone,a new ingredient that prevents photoageing.Belot,Leroy,Bastin,Yang,Zhang,Toussaint,Meybeck & Salmon.Linkage/ Mimage summer school (Les Diablerets, Switzerland, 2007)
Réunion : Development of full-thickness human skin cultures to investigate dermal and epidermal photo-ageing in a 3D model. Dedessus le Moutier, Salmon, Belot, Seltmann, Zouboulis & Toussaint. Link-age / Mimage Summer School (Les Diablerets, Switzerland, 2007)
Colloque : Morrhaye, Bruck, De St-Hubert, Weemaels, Schaaf-Lafontaine, Swine, Toussaint, Geenen & Martens. Immunology 2007, 94th Annual Meeting. First characterization of immunosenescence involvement in the frailty syndrome (Miami, FL, USA, 2007)
Réunion : Proteomic profiling during premature senescence induced by subcytotoxic UVB stresses in skin human fibroblasts, Flament, delaive, Dieu, Larsen, Leprince, Roepstorff, Raes, Remacle & Toussaint. Réunion du groupe de contact FNRS Protéomique (Namur, FUNDP, 2007)
Réunion : Accelerated differentiation of human keratinocytes after repeated subcytotoxic exposures to UVB and study of protein oxidation. Vallery, Friguet, Bulteau, Remacle, Poumay & Toussaint. (Innsbruck, Austria, 2006)
Réunion : Involvement of p53 in UVB induced premature senescence. Borlon, Debacq-Chainiaux, Remacle & Toussaint. European Conference on Ageing. (Innsbruck, Austria, 2006)
Conférence : Long term DNA damage in premature senescence induced by UVB. Debacq-Chainiaux, Borlon, Deglas, Ninane, de Longueville, Remacle & Toussaint. European Conference on Ageing (Innsbruck, Austria, 2006)
Réunion : Proteins differentially expressed in premature senescence induced by subcytotoxic H2O2 stress in human diploid fibroblasts. Chrétien, Delaive, Raes, Remacle & Toussaint. European Conference on Ageing (Innsbruck, Austria, 2006)
Réunion : Oxidative stress-induced rpe cell senescence: an in vitro model for amd. Glotin, Debacq-Chainiaux, Brossas, Tréton, Toussaint & Mascarelli. European Conference on Ageing (Innsbruck, Austria, 2006)
Conférence : Il-6, TNF-alpha et IGF-1 chez des personnes âgés en relativement bonne santé. De Saint-Hubert, Thimus, Delieux, Morrhaye, Weemaels, Martens, Toussaint & Swine. 9è journées d'automne de la Société Belge de Gérontologie et Gériatrie (Liège, 2006)
Conférence : Changes in expression levels and protein phosphorylation during premature senescence induced by subcytotoxic UVB stresses in skin human fibroblasts. Flament, Delaive, Dieu, Larsen, Leprince, Roepstorff, Raes, Remacle & Toussaint. (Luxembourg-Kirchberg, Luxembourg, 2006)
Réunion : Proteins differentially expressed in premature senescence induced by subcytotoxic H2O2 stress in human diploid fibroblasts. Oxydo-réduction des cystéines et signalisation intracellulaire. Chrétien,Delaive,Remacle,Dierick,Lorentzen,Larsen,Roepst. (Woluwé, 2006): Réunion du groupe de contact FNRS Phénomènes oxydatifs et antioxydants
Réunion : Accelerated differentiation of human keratinocytes after repeated subcytotoxic exposures to UVB and study of protein oxidation Oxydo-réduction des cystéines et signalisation intracellulaire. Vallery, Remacle, Poumay & Toussaint. Réunion groupe FNRS (Woluwé, 2006)
Réunion : Accelerated differentiation of human keratinocytes after repeated subcytotoxic exposures to UVB and study of protein oxidation. Vallery, Friguet, Bulteau, Remacle, Poumay & Toussaint. 4ème colloque "Protéolyse Cellulaire" de la SFBBM (Aussois, France, 2005)
Réunion : UVB-induced premature senescence in skin human fibroblasts : proteomic analysis. Flament , Delaive, Dieu, Leprince, Raes, Remacle & Toussaint. Meeting 'protéomique quantitative', Groupe de contact FNRS protéomique (Liège, 2005)
Réunion : A proteomic study reveals new effectors involved in the appearance of premature senescence induced by subcytotoxic H2O2 stress in human diploid fibroblasts. Chrétien, Delaive, Remacle, Dierick, Lorentzen, Larsen, Roepstorff & Toussaint. (Liège, 2005): Meeting 'protéomique quantitative', Groupe de contact FNRS protéomique
Réunion : Accelerated differentiation of human keratinocytes after repeated subcytotoxic exposures to UVB. Vallery, Remacle, Poumay & Toussaint. Xth Belact (Bruxelles, 2004)
Réunion : Proteomic Study To Identify Protein Expression Changes In Premature Senescence Induced By Subcytotoxic Uvb Stresses In Skin Human Fibroblasts. Flament , Delaive, Dieu, Leprince, Raes, Remacle & Toussaint. Xth Belact Meeting (Bruxelles, 2004)
Réunion : Proteomics study of premature senescence of human diploid fibroblasts induced by subcytotoxic H2O2 stress. Chrétien, Delaive, Remacle, Dierick, Lorentzen, Larsen, Roepstorff & Toussaint. Xth BELACT (Bruxelles, 2004)
Conférence : Regulated transcription in UVB induced premature senescence. Borlon, Chainiaux, Remacle & Toussaint. European congress, Signal Transduction (Kirchberg, Luxembourg, 2004)
Conférence : Proteomics study discriminating proteins undergoing expression of human fibroblasts induced dependently or independently of TGF-B1. Chrétien, Delaive, Remacle & Toussaint. European Conference Center, Signal Transduction (Kirchberg, Luxembourg, 2004)
Réunion : UVB-induced premature senescence. Chainiaux, Borlon, Antoine, Vertez, Remacle & Toussaint. FEBS Meeting Signal Transduction (Bruxelles, 2003)
Réunion : Transcriptomic study of H2O2-induced premature senescence of human diploid fibroblasts using low-density cDNA array 'seneschips'. Zdanov, Zammatteo, de Longueville, Parmentier, Boffe, Remacle & Toussaint. FEBS Meeting : Signal Transduction (Bruxelles, 2003)
Réunion : How Transforming Growth Factor-ß1 induces stress-induced premature senescence of human diploid fibroblasts ? Zdanov, Frippiat, Remacle & Toussaint. Bioforum (Liège, 2003)
Réunion : Development of a UVB-SIPS model as toxicological tool. Chainiaux, Borlon, Antoine, Vertez, Eliaers, Remacle & Toussaint. Bioforum (Liège, 2003)
Réunion : Transcriptomic study of UVB-induced premature senescence of human diploid skin fibroblasts using ad hoc customized low-density cDNA arrays. Borlon, Chainiaux, Zdanov, Remacle, de Longueville & Toussaint. (VUB, Bruxelles, 2003): Belgian Group for Animal Cell Technology Cell therapy : from stem cells to gene therapy
Réunion : Role of Transforming Growth Factor-ß1 in the establishment of subcytotoxic H2O2 stress-induced premature senescence of human diploid fibroblasts. Zdanov, Frippiat, Remacle & Toussaint (VUB, Bruxelles, 2003): Belgian Group for Animal Cell Technology Cell therapy : from stem cells to gene therapy
Réunion : Induction of premature senescence with tert-butylhydroperoxide and H2O2 in WI-38 human fibroblasts that express the catalytic subunit of human telomerase (h-TERT). 20. Chiarizia, Eliaers, Toussaint & Salmon. (VUB, Bruxelles, 2003): Belgian Group for Animal Cell Technology Cell therapy : from stem cells to gene therapy.

Activités avec simple participation

Réunion : General Assembly of the European Technology Platform of Nanomedecine, Workshop "Targeted drug delivery and release", Nanotoxicology, a part of nanomedicine. Toussaint & Saout. (UCB Center, Brussels, 2008)
Réunion : Effect of copper sulfate on human fibroblasts : stress-induced premature senescence. Boilan, Debacq-Chainiaux, Matos, Osiewacz & Toussaint. Link-age / Mimage Summer School (Les Diablerets, Switzerland, 2007)
Colloque : 5th European Congress of Biogerontology (Istambul, Turkey, 2006)
Séminaire : XIII Biennial Meeting of the International Society for Free Radical Biology and Medicine (Davos, Switzerland, 2006)
Formation : 19th IUBMB International Congress of Biochemistry and Molecular Biology. (Montreal, Canada, 2003): Stress-induced premature senescence : from in vitro to in vivo data.

Publications (109)

2009

Potential nanotoxicity in blood : Effects of engineered nanoparticles on human blood constituents, in Nanofac 2009
Julie LALOY, Catherine MARBEHANT, Severine ROBERT, François MULLIER, Bernard CHATELAIN, Jean-Michel DOGNÉ, Olivier TOUSSAINT, Bernard MASEREEL, Stéphanie ROLIN

Contributions à des ouvrages collectifs

2010

p38MAPK in the Senescence of Human and Murine Fibroblasts, in Advances in Experimental Medicine and Biology Review, volume 694, pp. 126-137
Florence CHAINIAUX-DEBACQ, Emmanuelle BOILAN, Jeremie DEDESSUS LE MOUTIER, Geoffroy WEEMAELS, Olivier TOUSSAINT

2002

Radicaux libres et antioxydants dans le vieillissement, in Gérontologie préventive. Eléments de prévention du vieillissement pathologique, pp. 35-49
Patrick DUMONT, Veronique ROYER, Christophe FRIPPIAT, Thierry PASCAL, José REMACLE, Olivier TOUSSAINT

2002

Vieillissement cellulaire et sénescence réplicative, in Gérontologie préventive, pp. 25-34
Patrick DUMONT, Florence CHAINIAUX-DEBACQ, Jean-François DIERICK, José REMACLE, Olivier TOUSSAINT

2000

Nutrition, vieillissement et modèles in vitro permettant de tester les effets à long terme potentiels d'additifs alimentaires en développement dans l'industrie agro-alimentaire, in L'impact de la nutrition sur la santé, pp. 79-86
Olivier TOUSSAINT, Pierre LEMAIRE, Patrick DUMONT, Jean-François DIERICK, Thierry PASCAL, Christophe FRIPPIAT, Florence CHAINIAUX-DEBACQ, Joao Pedro MAGALHAES, François ELIAERS, Anne-France DABEE, José REMACLE

2000

Transcriptome and proteome analysis in human senescent fibroblasts and fibroblasts undergoing premature senescence induced by repeated sublethal stresses, in Molecular and cellular gerontology, collection Annals of the New York academy of sciences, volume 908, pp. 302-305
Jean-François DIERICK, Thierry PASCAL, Florence CHAINIAUX-DEBACQ, François ELIAERS, José REMACLE, Peter Mose LARSEN, Peter ROEPSTORFF, Olivier TOUSSAINT

2000

Human diploid fibroblasts display a decreased level of c-fos mRNA at 72 hours after exposure to sublethal H₂O₂ stress, in Molecular and cellular gerontology, collection Annals of the New York academy of sciences, volume 908, pp. 306-309
Patrick DUMONT, Maggi BURTON, Qin CHEN, Christophe FRIPPIAT, Thierry PASCAL, Jean-François DIERICK, François ELIAERS, Florence CHAINIAUX-DEBACQ, José REMACLE, Olivier TOUSSAINT

2000

Stress-induced premature senescence: essence of life, evolution, stress, and aging, in Molecular and cellular gerontology, collection Annals of the New York academy of sciences, volume 908, pp. 85-98
Olivier TOUSSAINT, Patrick DUMONT, Jean-François DIERICK, Thierry PASCAL, Christophe FRIPPIAT, Florence CHAINIAUX-DEBACQ, Francis SLUSE, François ELIAERS, José REMACLE

1996

From molecular gerontology to healthy old age: research strategies, in Molecular gerontology, pp. 201-209
Olivier TOUSSAINT, Suresh RATTAN

1996

Cellular ageing, energy production and stress, in Vitality, mortality and aging, collection Vienna aging series, volume 5, pp. 167-172
José REMACLE, Olivier TOUSSAINT

1996

Stress and energy metabolism in age-related processes, in Molecular gerontology, pp. 87-109
Olivier TOUSSAINT, José REMACLE

1995

Bioenergetics of mitochondria determine cell survival in stressful conditions, in Thirty years of progress in mitochondrial bioenergetics and molecular biology, collection Progress in cell research, volume 5, pp. 237-241
P. CORBISIER, Olivier TOUSSAINT, José REMACLE

1995

Protective effect of Ginkgo biloba extract (EGb 761) and bilobalide against mortality and accelerated cellular aging under stressful conditions, in Effects of Ginkgo biloba extract (EGb 761) on aging and age-related disorders, collection Advances in Ginkgo biloba extract research, volume 4, pp. 1-16
Olivier TOUSSAINT, François ELIAERS, Andrée HOUBION, José REMACLE, K. DRIEU

Articles de périodique

2012

Quantification of nanoparticles in aqueous food matrices using Particle-Induced X-ray Emission: DOI 10.1007/s00216-012-5895-9, in Analytical and Bioanalytical Chemistry
Omar LOZANO GARCIA, Jorge Humberto MEJIA MENDOZA, Tijani TABARRANT, Bernard MASEREEL, Jean-Michel DOGNÉ, Olivier TOUSSAINT, Stephane LUCAS

2012

Are stirring and sonication pre-dispersion methods equivalent for in vitro toxicology evaluation of SiC and TiC?, in Journal of Nanoparticle Research, volume 14, issue 4
Jorge Humberto MEJIA MENDOZA, Vanessa VALEMBOIS, Jean-Pascal PIRET, Marijn VAN HUIS, Frans TICHELAAR, Bernard MASEREEL, Olivier TOUSSAINT, Joseph DELHALLE, Zineb MEKHALIF, Stephane LUCAS

2011

Development of a PIXE analysis method for the determination of the biopersistence of SiC and TiC nanoparticles in rat lungs, in Nanotoxicology, DOI: 10.3109/17435390.2011.572301
Omar LOZANO GARCIA, Jorge Humberto MEJIA MENDOZA, Bernard MASEREEL, Olivier TOUSSAINT, Dominique LISON, Stephane LUCAS

2011

Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls.- doi:10.1016/j.exger.2010.10.012, in Experimental Gerontology, volume 11, issue 46, pp. 257-264
Thi Kim Duy VO, Patrice GODARD, M. DE SAINT HUBERT, G. MORRHAYE, Florence CHAINIAUX-DEBACQ, C. SWINE, V. GEENEN, H.-J. MARTENS, Olivier TOUSSAINT

2011

Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison with hospitalized geriatric patients with infectious diseases or hip fracture, in Mech Ageing Dev - doi:10.1016/j.mad.2011.02.002, volume 132, pp. 131-139
Thi Kim Duy VO, Marie DE SAINT HUBERT, Gabriel MORRHAYE, Patrice GODART, Vincent GEENEN, Henri J. MARTENS, Florence CHAINIAUX-DEBACQ, Christian SWINE, Olivier TOUSSAINT

2011

Pro-inflammatory effects of different MWCNTs dispersions in p16INK4A-deficient telomerase-expressing human keratinocytes but not in human SV-40 immortalized sebocytes - doi:10.3109/17435390.2011.558642, in Nanotoxicology - Early online, volume 1, issue 17
Sebastien VANKONINGSLOO, Jean-Pascal PIRET, Christelle SAOUT, Florence NOEL, Jorge Humberto MEJIA MENDOZA, Alain COQUETTE, Christos C. ZOUBOULIS, Joseph DELHALLE, Stephane LUCAS, Olivier TOUSSAINT

2011

Effects of the dispersion methods in Pluronic F108 on the size and the surface composition of MWCNTs and their implications in toxicology assessment, in Journal of Nanoparticule Research, volume 13, issue 2, pp. 655-667
Jorge Humberto MEJIA MENDOZA, Frans TICHELAAR, Christelle SAOUT, Olivier TOUSSAINT, Bernard MASEREEL, Zineb MEKHALIF, Stephane LUCAS, Joseph DELHALLE

2011

Validation of the calibrated thrombin generation test (cTGT) as the reference assay to evaluate the procoagulant activity of nanomaterials. doi: 10.3109/17435390.2011.569096, in Nanotoxicology
Julie LALOY, Severine ROBERT, Catherine MARBEHANT, François MULLIER, Jorge Humberto MEJIA MENDOZA, Jean-Pascal PIRET, Stephane LUCAS, Bernard CHATELAIN, Jean-Michel DOGNÉ, Olivier TOUSSAINT, Bernard MASEREEL, Stéphanie ROLIN

2011

Serum IL-6 and IGF-1 improve clinical prediction of functional decline after hospitalization in older patients , in Aging Clinical and Experimental Research - doi10.3275/7028, volume 23, issue 2, pp. 106-111
Marie DE SAINT HUBERT, Jacques JAMART, Gabriel MORRHAYE, Henri J. MARTENS, Vincent GEENEN, Thi Kim Duy VO, Olivier TOUSSAINT, Christian SWINE

2010

Eco-, geno- and human toxicology of bio-active nanoparticles for biomedical applications. , in Toxicology, volume 269, pp. 170-181
J. ROBBENS, C. VANPARYS, J. NOBELS, R. BLUST, K. VAN HOECKE, C. JANSSEN, K. DE SCHAMPHELAERE, Kathleen ROLAND, Gersande BLANCHARD, Frederic SILVESTRE, Virginie GILLARDIN, Patrick KESTEMONT, R. ANTONISSEN, Olivier TOUSSAINT, Christelle SAOUT, Sebastien VANKONINGSLOO, E. ALFARO-MORENO, P. HOE, L. GONZALES, P. DUBRUEL, P. TROISFONTAINE

2010

Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases, doi:10.1186/1742-4933-7-9, in Immunity & Ageing, volume 7, issue 9
Thi Kim Duy VO, Patrice GODARD, Marie DE SAINT HUBERT, Gabriel MORRHAYE, Christian SWINE, Vincent GEENEN, Henri J MARTENS, Florence CHAINIAUX-DEBACQ, Olivier TOUSSAINT

2010

Serum N-glycan profile shift during human ageing, in Experimental Gerontology, volume 45, pp. 738-743
Valerie VANHOOREN, Sylviane DEWAELE, Claude LIBERT, Sebastiaan ENGELBORGHS, Peter Paul DE DEYN, Olivier TOUSSAINT, Florence CHAINIAUX-DEBACQ, Michel POULAIN, Youri GLUPZYNSKI, Claudio FRANCESCHI, Koos JASPERS, Ingrid VAN DER PLUIJM, Jan HOEIJMAKERS, Chen CHITTY

2010

Proteomic profiling of human keratinocytes undergoing UVB-induced alternative differentiation reveals TRIpartite motif protein 29 as a survival factor, in PLoS ONE/ www.plosone.org/e10462, volume 5, issue 5
Veronique VALLERY, Nathalie BELOT, Marc DIEU, Edouard DELAIVE, Noelle NINANE, Catherine DEMAZY, Martine RAES, Michel SALMON, Yves POUMAY, Florence CHAINIAUX-DEBACQ, Olivier TOUSSAINT

2010

Physio-pathological parameters affect the activation of inflammatory pathways by deoxynivalenol in Caco-2 cells , in Toxicology in Vitro, volume 24, pp. 1890-1894
Jacqueline VAN DE WALLE, Alexandre DURING, Neil PIRONT, Olivier TOUSSAINT, Yves-Jacques SCHNEIDER, Yvan LARONDELLE

2010

Dispersion of multi-walled carbon nanotubes in biocompatible dispersants, in J. Nanoparts Res., volume 12, issue 1, pp. 75-82
Jean-Pascal PIRET, Simon DETRICHE, Renaud VIGNERON, Sebastien VANKONINGSLOO, Stéphanie ROLIN, Jorge Humberto MEJIA MENDOZA, Bernard MASEREEL, Stephane LUCAS, Joseph DELHALLE, Frédéric LUIZI, Christelle SAOUT, Olivier TOUSSAINT

2010

Deoxynivalenol affectsinvitrointestinal epithelial cell barrier integrity through inhibitionof proteinsynthesis, in Toxicology and Applied Pharmacology, volume 245, pp. 291-298
Jacqueline VAN DE WALLE, Thérèse SERGENT, Neil PIRONT, Olivier TOUSSAINT, Yves-Jacques SCHNEIDER, Yvan LARONDELLE

2010

Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study., in PlOS One, volume 10
G. ROSE ET AL (...), Olivier TOUSSAINT

2010

Artefactual Effects ofq1 Oxygen on Cell Culture Models of Cellular Senescence and Stem Cell Biology, in Journal of Cellular Physiology - DOI: 10.1002/jcp.22416 , pp. 315-321
Olivier TOUSSAINT, Geoffroy WEEMAELS, Florence CHAINIAUX-DEBACQ, K. SCHARFEFETTER-KOCHANEK, M. WLASCHEK

2010

Eco-, geno- and human toxicology of bio-active nanoparticles for biomedical applications, in Toxicology - doi:10.1016/j.tox.2009.11.002, pp. 170-181
J. ROBBENS ET AL (...), Kathleen ROLAND, Gersande BLANCHARD, Frederic SILVESTRE, Virginie GILLARDIN, Patrick KESTEMONT, Olivier TOUSSAINT, Sebastien VANKONINGSLOO, Christelle SAOUT

2010

Repeated exposures to UVB induce differentiation rather than senescence of human keratinocytes lacking p16INK-4A , in Biogerontology, pp. 167-181
Veronique VALLERY, Emmanuelle BOILAN, Noelle NINANE, Catherine DEMAZY, B. FRIGUET, Olivier TOUSSAINT, Yves POUMAY, Florence CHAINIAUX-DEBACQ

2010

Effects of the dispersion methods in Pluronic F108 on the size and the surface composition of MWCNTs and their implications in toxicology assessment, in J Nanoparts Res, DOI 10 1007/s11051-010-0063-7
Jorge MEJIA, Frans TICHELAAR, Christelle SAOUT, Olivier TOUSSAINT, Bernard MASEREEL, Zineb MEKHALIF, Stephane LUCAS, Joseph DELHALLE

2010

Transcriptomic biomarkers of human ageing in peripheral blood monocluear cell total RNA, in Experimental Gerontology, volume 45, pp. 188-194
Thi Kim Duy VO, Patrice GODARD, Marie DE SAINT HUBERT, Gabriel MORRHAYE, Emilie BAUWENS, Florence CHAINIAUX-DEBACQ, Youri GLUPCZYNSKI, Christian SWINE, Vincent GENNEN, Henri J. MARTENS, Olivier TOUSSAINT

2010

Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium, in Chemico-Biological Interactions, volume 188, pp. 659-667
Thérèse SERGENT, Neil PIRONT, Julie MEURICE, Olivier TOUSSAINT, Yves-Jacques SCHNEIDER

2010

Cytotoxicity of multi-walled carbon nanotubes in three skin cellular models: Effects of sonication, dispersive agents and corneous layer of reconstructed epidermis - doi:10.3109/17435390903428869, in Nanotoxicology, volume 4, issue 1, pp. 84-97
Sebastien VANKONINGSLOO, Jean-Pascal PIRET, Christelle SAOUT, Florence NOEL, Joseph DELHALLE, Jorge Humberto MEJIA MENDOZA, Christos C. ZOUBOULIS, Stephane LUCAS, Olivier TOUSSAINT

2009

Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts, in Plos one, volume 4, issue 3, pp. 1-14
Christian Q. SCHECKHUBER, Jürgen GRIEF, Emmanuelle BOILAN, Karin LUCE, Florence CHAINIAUX-DEBACQ, Claudia RITTMEYER, Ricardo GREDILLA, Benrnd O. KOLBESEN, Olivier TOUSSAINT, Heinz D. OSIEWACZ

2009

p53 and ATF-2 partly mediate the overexpression of COX-2 in H₂O₂-induced premature senescence of human fibroblasts, in Biogerontology, volume 10, pp. 291-298
Stéphanie ZDANOV, Olivier TOUSSAINT, Florence CHAINIAUX-DEBACQ

2009

The development of nanotoxicity assays,... for regulatory purposes, in Public Service Review, Science and Technology, volume 4, pp. 1-2
Christelle SAOUT, Olivier TOUSSAINT

2009

Protocols to detect senescence-associated beta-galactosidase (SA-Βgal) activity, a biomarker of senescent cells in culture and in vivo, in Nature protocols, volume 4, issue 12, pp. 1798-1806
Florence CHAINIAUX-DEBACQ, Jorge ERUSALIMSKY, Judith CAMPISI, Olivier TOUSSAINT

2008

Biological models for phytochemical research: from cell to human organism, in British Journal of Nutrition, volume 99, issue E-Suppl 1, pp. 118-126
Alicja MORTENSEN, Ilona K. SORENSEN, Colin WILDE, Stefania DRAGONI, Dana MULLEROVA, Olivier TOUSSAINT, Zdenek ZLOCH, Giampietro SGARAGLI, Jaroslava OVESNA

2008

Role of TGF-⓵-independent changes in protein neosynthesis, p38α^MAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis, in Free Radical Biology & Medicine, volume 44, issue 9, pp. 1732-1751
Aline CHRÉTIEN, Jean-François DIERICK, Edouard DELAIVE, Martin ROSSEL-LARSEN, Marc DIEU, Martine RAES, Christophe F. DEROANNE, Peter ROEPSTORFF, Olivier TOUSSAINT

2008

Replicative aging down-regulates the myogenic regulatory factors in human myoblasts, in Biol. Cell, volume 100, issue 3, pp. 189-199
Anne BIGOT, Virginie JACQUEMIN, Florence CHAINIAUX-DEBACQ, Gillian S. BUTLER-BROWNE, Olivier TOUSSAINT, Denis FURLING, Vincent MOULY

2008

Screening of senescence-associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblasts, in Free Radical Biology & Medicine, volume 44, pp. 1817-1832
Florence CHAINIAUX-DEBACQ, Thierry PASCAL, Emmanuelle BOILAN, Coralie BASTIN, Emilie BAUWENS, Olivier TOUSSAINT

2008

High throughput 'omics' approaches to assess the effects of phytochemicals in human health studies, in British Journal of Nutrition, volume 99, issue E-Suppl 1, pp. 130-137
Jaroslava OVESNA, Ondrej SLABY, Olivier TOUSSAINT, Milan KODICEK, Petr MARSIK, Vladimira POUCHOVA, Tomas VANEK

2008

Prematurely senescent ARPE-19 cells display features of age-related macular degeneration, in Free Radical Biology & Medicine, volume 44, pp. 1348-1361
Anne-Lise GLOTIN, Florence CHAINIAUX-DEBACQ, Jean-Yves BROSSAS, Anne-Marie FAUSSAT, Jacques TRETON, Anna ZUBIELEWICZ, Olivier TOUSSAINT, Frédéric MASCARELLI

2008

Upregulation of annexin A2 in H₂0₂-induced premature senescence as evidence by 2D-DIGE proteome analysis, in Experimental Gerontology, volume 43, pp. 353-359
Aline CHRÉTIEN, Edouard DELAIVE, Marc DIEU, Catherine DEMAZY, Noelle NINANE, Martine RAES, Olivier TOUSSAINT

2008

Identification of p53-dependent genes potentially involved in UVB-mediated premature senescence of human skin fibroblasts using siRNA technology, in Mechanisms of Ageing and Development, volume 129, issue 3, pp. 109-119
Celine BORLON, Sebastien VANKONINGSLOO, Patrice GODARD, Florence CHAINIAUX-DEBACQ, Olivier TOUSSAINT

2008

Increased abundance of cytoplasmic and nuclear caveolin 1 in human diploid fibroblast in H₂O₂-induced premature senescence and interplay with p38α^MAPK, in FEBS letter, volume 582, issue 12, pp. 1685-1692
Aline CHRÉTIEN, Neil PIRONT, Edouard DELAIVE, Catherine DEMAZY, Noelle NINANE, Olivier TOUSSAINT

2008

Expression profiling of senescent-associated genes in human dermis from young and old donors: proof-of-concept study, in Biogerontology, volume 9, issue 3, pp. 197-208
Celine BORLON, Geoffroy WEEMAELS, Patrice GODARD, Florence CHAINIAUX-DEBACQ, Pierre LEMAIRE, Christophe DEROANNE, Olivier TOUSSAINT

2007

Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblast induced by tert-butylhydroperoxide and ethanol, in Biogerontology, volume 8, pp. 409-422
Thierry PASCAL, Florence CHAINIAUX-DEBACQ, Emmanuelle BOILAN, Noelle NINANE, Martine RAES, Olivier TOUSSAINT

2006

Identification of potential anti-photoageing algal compounds using an in-vitro model of photoageing, in Journal of Pharmacy and Pharmacology, volume 58, pp. 1577-1583
Florence CHAINIAUX-DEBACQ, Celine BORLON, Benoît DE HERTOGH, José REMACLE, P.-Y. MORVAN, R. VALLEE, Olivier TOUSSAINT

2006

Identification of p38(MAPK)-dependent genes with changed transcript abundance in H(2)O(2)-induced premature senescence of IMR-90 hTERT human fibroblasts, in FEBS Letters, volume 580, issue 27, pp. 6455-6463
Stéphanie ZDANOV, Florence CHAINIAUX-DEBACQ, José REMACLE, Olivier TOUSSAINT

2005

Informed consent of very old patients and modern genomics, in Biogerontology, volume 6, pp. 81-84
Eric MATTHEWS, Erica HAIMES, Anne-Marie DUGUET, Brian CLARK, Christian SWINE, Olivier TOUSSAINT

2005

HAGR- The human aging genomic ressources, in Nucleic Acids Research, volume 33, pp. D537-D547
JP DE MAGALHAES, J COSTA, Olivier TOUSSAINT

2005

Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays, in FEBS Letters, volume 579, issue 17, pp. 3651-3659
Thierry PASCAL, Florence CHAINIAUX-DEBACQ, Aline CHRÉTIEN, Coralie BASTIN, Anne-France DABEE, Vincent BERTHOLET, José REMACLE, Olivier TOUSSAINT

2005

Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-B1 signaling pathway, in Journal of Cell Science, volume 118, issue 4, pp. 743-758
Florence CHAINIAUX-DEBACQ, Celine BORLON, Thierry PASCAL, Veronique ROYER, François ELIAERS, Noelle NINANE, Géraldine CARRARD, Bertrand FRIGUET, Françoise DE LONGUEVILLE, Sophie BOFFE, José REMACLE, Olivier TOUSSAINT

2004

Gene expression and regulation in H2O2-induced premature senescence of human fibroblasts expressing or not telomerase, in Experimental Gerontology, volume 39, pp. 1379-1389
Joao Pedro DE MAGALHAES, Florence CHAINIAUX-DEBACQ, Françoise DE LONGUEVILLE, Véronique MAINFROID, Valérie MIGEOT, Laurence MARCQ, José REMACLE, Michel SALMON, Olivier TOUSSAINT

2004

How bioinformatics can help reverse engineer human aging, in Ageing Research Reviews, volume 3, pp. 125-141
Joao Pedro DE MAGALHAES, Olivier TOUSSAINT

2004

Role of the PLA2-independent peroxiredoxin VI activity in the survival of immortalized fibroblasts exposed to cytotoxic oxidative stress, in FEBS Letters, volume 557, pp. 26-32
Michel SALMON, Jeremie DEDESSUS LE MOUTIER, Frederic WENDERS, Sophie CHIARIZIA, François ELIAERS, José REMACLE, Veronique ROYER, Thierry PASCAL, Olivier TOUSSAINT

2003

Normal brain aging : a commentary, in Neurobiology of aging, volume 24, pp. 129-130
Olivier TOUSSAINT

2003

Impact of ageing on proteasome structure and function in human lymphocytes, in The international journal of Biochemistry & Cell biology, volume 35, pp. 728-739
Géraldine CARRARD, Marc DIEU, Martine RAES, Olivier TOUSSAINT, Bertrand FRIGUET

2003

View of a young biogerontologist on the in vitro biogerontological model systems, in Experimental Gerontology, volume 38, pp. 1229-1230
Olivier TOUSSAINT

2003

Retrovirally mediated overexpression of peroxiredoxin VI increases the survival of WI-38 human diploid fibroblasts exposed to cytotoxic doses of tert-butylhydroperoxide and UVB, in Biogerontology, volume 4, pp. 125-131
Jean-François DIERICK, Frederic WENDERS, Florence CHAINIAUX-DEBACQ, José REMACLE, Olivier TOUSSAINT, Aron FISHER

2003

Role of subcytotoxic stress in tissue ageing, in Topics in current genetics, volume 3, pp. 269-294
Olivier TOUSSAINT, Michel SALMON, Veronique ROYER, Jean-François DIERICK, Joao PEDRO DE MAGALHAES, Frederic WENDERS, Stéphanie ZDANOV, Aline CHRÉTIEN, Celine BORLON, Thierry PASCAL, Florence CHAINIAUX-DEBACQ

2002

Stress-induced premature senescence: from biomarkers to likeliness of in vivo occurrence, in Biogerontology, volume 3, pp. 13-17
Olivier TOUSSAINT, José REMACLE, Jean-François DIERICK, Thierry PASCAL, Christophe FRIPPIAT, Veronique ROYER, Joao Pedro MAGALHAES, Stéphanie ZDANOV, Florence CHAINIAUX-DEBACQ

2002

Radicaux libres et antioxydants dans le vieillissement, in Gérontologie préventive, pp. 35-49
Patrick DUMONT, Veronique ROYER, Christophe FRIPPIAT, Thierry PASCAL, José REMACLE, Olivier TOUSSAINT

2002

Proteomics in experimental gerontology, in Experimental gerontology, volume 37, pp. 721-734
Jean-François DIERICK, Marc DIEU, José REMACLE, Martine RAES, Peter ROEPSTORFF, Olivier TOUSSAINT

2002

Exposure of skin human diploid fibroblasts to repeated subcytotoxic doses of UVB induces the overexpression of the TGF-B1 mRNA, in NY Acad Sci, volume 973, pp. 44-48
Florence CHAINIAUX-DEBACQ, José REMACLE, Olivier TOUSSAINT

2002

From the Hayflick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing, in The International Journal of Biochemistry & Cell biology, volume 34, pp. 1415-1429
Olivier TOUSSAINT, José REMACLE, Jean-François DIERICK, Thierry PASCAL, Christophe FRIPPIAT, Stéphanie ZDANOV, Joao Pedro MAGALHAES, Veronique ROYER, Florence CHAINIAUX-DEBACQ

2002

Signal transduction in H2O2-induced senescence-like phenotype in human diploid fibroblasts, in Free Radical biology & Medecine, volume 33, pp. 1334-1346
Christophe FRIPPIAT, Janique DEWELLE, José REMACLE, Olivier TOUSSAINT

2002

Identification of 30 protein species involved in replicative senescence and stress-induced premature senescence, in FEBS Letters, volume 531, pp. 499-504
Jean-François DIERICK, Dario E. KALUME, Frederic WENDERS, Michel SALMON, Marc DIEU, Martine RAES, Peter ROEPSTORFF, Olivier TOUSSAINT

2002

UVB-induced premature senescence of human diploid skin fibroblasts, in The International Journal of Biochemistry & Cell Biology, volume 34, pp. 1331-1339
Florence CHAINIAUX-DEBACQ, Joao-Pedro MAGALHAES, François ELIAERS, José REMACLE, Olivier TOUSSAINT

2002

Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts, in FEBS Letters, volume 523, pp. 157-162
Joao Pedro DE MAGALHAES, Florence CHAINIAUX-DEBACQ, José REMACLE, Olivier TOUSSAINT

2002

Stress-induced premature senescence and tissue ageing, in Biochemical Pharmacology, volume 64, pp. 1007-1009
Olivier TOUSSAINT, Veronique ROYER, Michel SALMON, José REMACLE

2002

Down-regulation and decreased activity of cyclin-dependent kinase 2 in H2O2-induced premature senescence, in The International Journal of Biochemestry & Cell Biology , volume 1361, pp. 1-9
Christophe FRIPPIAT, José REMACLE, Olivier TOUSSAINT

2002

Les mécanismes moléculaires et cellulaires du vieillissement humain, in Sport à 50 ans
Olivier TOUSSAINT, José REMACLE

2002

Stress, cells and tissue ageing, in Biology of Aging and its modulation, SIS Rattan, in press, volume 5, pp. 101-125
Jean-François DIERICK, Christophe FRIPPIAT, Florence CHAINIAUX-DEBACQ, Olivier TOUSSAINT

2002

Stress-induced premature senescence or stress-induced senescence-like phenotype: one in vivo reality, two posssible defintions? How stress, cellular behaviors, growth kinetics and cell heterogeneity interact in senescence, in The Scientific World Journal, volume 2, pp. 230-247
Olivier TOUSSAINT, Patrick DUMONT, José REMACLE, Jean-François DIERICK, Thierry PASCAL, Christophe FRIPPIAT, Joao Pedro MAGALHAES, Stéphanie ZDANOV, Florence CHAINIAUX-DEBACQ

2002

Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence, in Biochemical Pharmacology, volume 64, pp. 1011-1017
Jean-François DIERICK, François ELIAERS, José REMACLE, Martine RAES, Stephen J. FEY, Peter Mose LARSEN, Olivier TOUSSAINT

2002

Overexpression of apolipoprotein J in human fibroblasts protects against cyotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide, in Cell Stress & Chaperones , volume 7, pp. 23-35
Patrick DUMONT, Florence CHAINIAUX-DEBACQ, François ELIAERS, chariklia PETROPOULOU, José REMACLE, Claudia KOCH-BRANDT, Efstathios S. GONOS, Olivier TOUSSAINT

2002

Approach of evolutionary theories of ageing, stress, senescence-like phenotypes, calorie restriction and hormesis from the view point of far-from-equilibrium thermodynamics, in Mechanisms of Ageing and Development, volume 123, pp. 937-946
Olivier TOUSSAINT, José REMACLE, Jean-François DIERICK, Thierry PASCAL, Christophe FRIPPIAT, Veronique ROYER, Florence CHAINIAUX-DEBACQ

2002

The evolution of mammalian aging, in Experimental Gerontology, volume 37, pp. 769-775
Joao Pedro de MAGALHAES, Olivier TOUSSAINT

2001

Subcytotoxic H₂O₂ stress triggers a release of transforming growth factor-β 1, which induces biomarkers of cellular senescence of human diploid fibroblasts, in Journal of Biological Chemistry, volume 276, issue 4, pp. 2531-2537
Christophe FRIPPIAT, Qin CHEN, Stephanie ZDANOV, Joao-Padro MAGALHAES, José REMACLE, Olivier TOUSSAINT

2000

Appearance of biomarkers of in vitro ageing after successive stimulation of WI-38 fibroblasts with IL-1α and TNF-α: senescence associated β-galactosidase activity and morphotype transition, in Journal of Anatomy, volume 197, pp. 529-537
Patrick DUMONT, Laura BALBEUR, José REMACLE, Olivier TOUSSAINT

2000

Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast, in Free Radical Biology and Medicine, volume 28, issue 3, pp. 361-373
Patrick DUMONT, Maggi BURTON, Qin CHEN, Efstathios GONOS, Christophe FRIPPIAT, Jean-Baptiste MAZARATI, François ELIAERS, José REMACLE, Olivier TOUSSAINT

2000

Cell cycle regulation in H₂O₂-induced premature senescence of human diploid fibroblasts and regulatory control exerted by the papilloma virus E6 and E7 proteins, in Experimental Gerontology, volume 35, pp. 733-745
Christophe FRIPPIAT, Qin CHEN, José REMACLE, Olivier TOUSSAINT

2000

Experimental gerontology in Belgium: from model organisms to age-related pathologies, in Experimental Gerontology, pp. 901-916
Olivier TOUSSAINT, BARET, BRION, CRAS, COLLETTE, DE DEYN, GEENEN, KIENLEN-CAMPARD, LABEUR, LEGROS, NÈVE, OCTAVE, PIÉRARD, SALMON, VAN DEN BOSCH DE AGUILAR, VAN DER LINDEN, LEUVEN, VANFLETEREN

2000

Cellular and molecular mechanisms of stress-induced premature senescece (SIPS) of human diploid fibroblasts and melanocytes, in Experimental Gerontology, pp. 927-945
Olivier TOUSSAINT, MEDRANO, VON ZGLINICKY

2000

Biology of ageing, in BioESsays, volume 22, pp. 954-956
Olivier TOUSSAINT, José REMACLE, Brian F.C. CLARK, Efstathios S. GONOS, Claudio FRANCESCHI, Thomas B.L. KIRKWOOD

2000

Stress-induced premature senescence as alternative toxicological method for testing the long-term effects of molecules under development in the industry, in Biogerontology, volume 1, pp. 177-181
Olivier TOUSSAINT, Patrick DUMONT, Jean-François DIERICK, Thierry PASCAL, Christophe FRIPPIAT, Florence CHAINIAUX-DEBACQ, Joao-Pedro MAGALHAES, François ELIAERS, José REMACLE

2000

Consideration of heteroduplexes and homoduplexes for the quantification by competitive PCR of human mitochondrial DNA deletions with ageing of tissues and cells, in Biogerontology, volume 1, pp. 279-283
Christophe FRIPPIAT, Jean-François DIERICK, José REMACLE, Olivier TOUSSAINT

2000

Molecular and cellular gerontology, in EMBO J., volume 19, pp. 1929-1934
Christine BRACK, Gordon LITHGOW, Olivier TOUSSAINT, OZIEWACZ

1998

La réponse des cellules aux stress: relation avec le processus de vieillissement et la pathologie, in M/S: médecine/sciences, volume 14, issue 5, pp. 622-635
Olivier TOUSSAINT, Martine RAES, Carine MICHIELS, José REMACLE

1998

Reciprocal relationships between the resistance to stresses and cellular aging, in Annals of the New York academy of sciences, volume 851, pp. 450-465
Olivier TOUSSAINT, Serge Y. FUCHS, Ze'Ev A. RONAI, Shogen ISOYAMA, Nitta YUKO, Valeria PETRONILLI, Paolo BERNARDI, Efstathios S. GONOS, Patrick DUMONT, José REMACLE

1998

Stress, aging, and neurodegenerative disorders: molecular mechanisms, in Annals of the New York academy of sciences, volume 851, pp. 429-443
Jorge BUSCIGLIO, Julie K. ANDERSEN, Hyman M. SCHIPPER, Gad M. GILAD, Richard MCCARTY, Fulvio MARZATICO, Olivier TOUSSAINT