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Membre du personnel

Nicole MOGUILEVSKY

Docteur en Sciences

Téléphone: 081/725047
Fax: 081/725701
Mail:

Charges aux FUNDP

  • Administration de la recherche (Responsable Cellule "Valorisation des résultats de la recherche" Responsable du projet MIRVAL (Mise en Réseau de la Valorisation), projet FSE/RW, 2007-2013 )

Diplômes

Doctorat en Sciences Biochimiques, Université Paris Diderot-Paris 7

Domaines de compétences

Biotechnologie/Biologie moléculaire. Valorisation de la Recherche.

Protection et gestion de la propriété intellectuelle. Transfert de Technologie et de savoir-faire. Création de Spin-off.

Charges externes

Responsable du projet MIRVAL (Mise en Réseau de la Valorisation de la Recherche 2007-2013. UE/RW)

Membre du Réseau LIEU (LIaison Entreprises-Universités)

Publications (98)

Contributions à des ouvrages collectifs

2002
The susceptibility of LDL to oxidation by myeloperoxidase is related to the differential count of monocytes. In : Atherosclerosis: risk factors, diagnosis and treatment., in Atherosclerosis : risk factors, diagnosis and treatment, pp. 159-163
Nicole MOGUILEVSKY, K. ZOUAOUI BOUDJLTIA, Y. CARPENTIER, A. BOLLEN, D. BROHEE, M. VANHAEVERBEEK, J. DUCOBU
2002
Myeloperoxidase oxidized-LDL delay fibrin clot lysis on the surface of endothelial cells. In : Atherosclerosis: risk factors, diagnosis and treatment., in Atherosclerosis: risk factors, diagnosis and treatment, pp. 179-182
K. ZOUAOUI BOUTJELTIA, Nicole MOGUILEVSKY, P. DELREE, M. ALVAREZ, J. DUCOBU, P. CAUCHIE, M. GUILLAUME, M. VANHAEVERBEEK, D. BROHEE, C. REMACLE
2001
Functional anatomy of the secretin receptor. In : Focus in Biotechnology, in Focus in Biotechnology
P. ROBBERECHT, M. WAELBROECK, Nicole MOGUILEVSKY
2000
Acquisition and use of myeloperoxidase in the microbicidal activity of macrophages. In : The Peroxidase Multigene Family of Enzymes: Biochemical Basis and Clinical Applications, in The Peroxidase Multigene Family of Enzymes: Biochemical Basis and Clinical Applications, pp. 68-71
L. MARODI, C. TOURNAY, R. KAPOSZTA, R.B. JOHNSTON, Nicole MOGUILEVSKY
2000
Structural and biological properties of human recombinant myeloperoxidase.In : The Peroxidase Multigene Family of Enzymes : Biochemical Basis and Clinical Applications, in The Peroxidase Multigene Family of Enzymes: Biochemical Basis and Clinical Applications , pp. 38-44
Nicole MOGUILEVSKY, A. BOLLEN
1999
Characterization of recombinant bovine lactoperoxidase produced by CHO cells. Animal Cell Technology : Challenges for the 21st Century., in Animal Cell Technology : Challenges for the 21st Century., pp. 93-97
S. WATANABE, K. SHIMAZAKI, A. BOLLEN, Nicole MOGUILEVSKY
1998
Rational drug design using mammalian cell lines expressing site-directed mutants of the human H1 histaminic receptor. In : Animal Cell Technology : basic and applied aspects, in Animal Cell Technology : basic and applied aspects, volume 9, pp. 65-69
Nicole MOGUILEVSKY, E. DIFFERDING, M. GILLARD, A. BOLLEN
1997
Recombinant human autoantigens as an extracorporeal immunoadsorbent in therapeutic apheresis, in Recombinant human autoantigens as an extracorporeal immunoadsorbent in therapeutic apheresis, volume 16, pp. 17-22
S. GRIFFIN, P. CHAPMAN, J. ELLIOT, A. BROWNLEC, A. SHORT, A. BARCLAY, Nicole MOGUILEVSKY, A. BOLLEN, M. LOCKWOOD
1994
Protective in vivo effect against murine Rickettsiae infection by recombinant myeloperoxidase produced in CHO cells. In: Animal Cell Technology: basic and applied aspects, in Animal Cell Technology: basic and applied aspects, volume 6, pp. 549-553
P. TOTTE, Nicole MOGUILEVSKY, N. VACHIERY, C. TOURNAY, A. BOLLEN, J. WERENNE
1994
L'apport du génie génétique dans l'évolution de la médecine., in L'apport du génie génétique dans l'évolution de la médecine., collection Technologies nouvelles et pratique médicale - Le défi du futur, volume 4, n°219, pp. 16-22
Nicole MOGUILEVSKY, A. BOLLEN
1993
Recombinant human proapolipoprotein A-I: experimental strategies for the production of an authentic molecule. NATO ASI Series, Vol.H73, Human Apolipoprotein Mutants III, in Human Apolipoprotein Mutants III, collection NATO ASI Series, volume H73, pp. 145-163
Nicole MOGUILEVSKY, F. VARSALONA, J.P. GUILLAUME, C. ROOBOL, A. BOLLEN
1992
Secretion of enzymatically active human recombinant myeloperoxidase by chinese hamster ovary cells in culture, in The Molecular Basis of Oxidative Damage by Leukocytes , collection Bozeman - CRC Press, pp. 289-292
Nicole MOGUILEVSKY, L. GARCIA-QUINTANA, A. JACQUET, C. TOURNAY, L. FABRY, L. PIÉRARD, A. BOLLEN
1989
Production of human recombinant apolipoprotein A-I in Escherichia coli and in baculovirus-infected insect cells, in Mededelingen van de Fakulteit Landbouwwetenschappen, collection Mededelingen van de Fakulteit Landbouwwetenschappen, pp. 1521-1526
Nicole MOGUILEVSKY, C. ROOBOL, L. HOLMQUIST, A. BOLLEN
1988
High level production of human proapolipoprotein A-I in baculovirus-infected insect cells. In: Advances in animal cell biology and technology for bioprocesses, in Advances in animal cell biology and technology for bioprocesses, pp. 507-509
D. GRÉGOIRE, Nicole MOGUILEVSKY, R. LORIAU, J.P. GUILLAUME, A. BOLLEN
1985
Study of lactoferrin-binding sites at the surface of blood monocytes. In: Proteins of iron Storage and Transport, in Proteins of iron Storage and Transport, pp. 199-202
Nicole MOGUILEVSKY, P.J. COURTOY, P.L. MASSON
1983
Resolution and limitations of the immunoperoxidase procedure (demonstration and partial control of diamino benzidine diffusion artifacts). In: Immunoenzymatic Techniques I, in Immunoenzymatic Techniques II, collection Elsevier, volume II, pp. 21-24
P.J. COURTOY, Nicole MOGUILEVSKY, D. HUNT-PINCTON, M.G. FARQUHAR
1983
Lactoferrin uptake by the reticuloendothelial system of the mouse liver. In : Protides of the biological Fluids, in Protides of the biological Fluids, volume 31, pp. 133-136
Nicole MOGUILEVSKY, L.A. RETEGUI, P.J. COURTOY, C. CASTRACANE, P.L. MASSON

Articles de périodique

2010
Copper and myeloperoxidase-modified LDLs activate Nrf2 through different pathways of ROS production in macrophages. Antioxid Redox Signal.13(10):1491-1502.
D CALAY, A ROUSSEAU, L MATTARD, V NUYENS, C DELPORTE, P VAN ANTWERPEN, Nicole MOGUILEVSKY, T ARNOULD, KZ BOUDJELTIA, M RAES
2010
Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity.J Biol Chem.21;285(21):16351-9.
P VAN ANTWERPEN, MC SLOMIANNY, KZ BOUDJELTIA, C DELPORTE, V FAID, D CALAY, A ROUSSEAU, Nicole MOGUILEVSKY, M RAES, L VANHAMME, PG FURTMÜLLER, C OBINGER, M VANHAEVERBEEK, J NÈVE, JC MICHALSKI
2008
Development and validation of a screening procedure for the assessment of inhibition using a recombinant enzyme.Talanta. 75:503-10.
P VAN ANTWERPEN, P MOREAU, K ZOUAOUI BOUDJELTIA, S BABAR, F DUFRASNE, Nicole MOGUILEVSKY, M VANHAEVERBEEK, J DUCOBU, J NEVE
2008
Conception of myeloperoxidase inhibitors derived from flufenamic acid by computational docking and structure modification. Bioorg Med Chem. 16:1702-20.
P VAN ANTWERPEN, M PRÉVOST, K ZOUAOUI-BOUDJELTIA, S BABAR, I LEGSSYER, P MOREAU, Nicole MOGUILEVSKY, M VANHAEVERBEEK, J DUCOBU, J NÈVE, F DUFRASNE
2007
Resveratrol inhibits the activity of equine neutrophil myeloperoxidase by a direct interaction with the enzyme. J Agric Food Chem. 55(20):8080-7.
S KOHNEN, T FRANCK, P VAN ANTWERPEN, K BOUDJELTIA ZOUAOUI, A MOUITHYS-MICKALAD, C DEBY, Nicole MOGUILEVSKY, G DEBY, N LAMY, D SERTEYN
2007
Probucol does not inhibit myeloperoxidase-dependent low-density lipoprotein oxidation as a potent protective effect in atherosclerosis. J Cardiovasc Pharmacol. 50(3):350-1
P VAN ANTWERPEN, J NÈVE, P MOREAU, K BOUDJELTIA ZOUAOUI, M VANHAEVERBEEK, M PRÉVOST, S BABAR, I LEGSSYER, Nicole MOGUILEVSKY, J DUCOBU
2007
Disruption of the aspartate to heme ester linkage in human myeloperoxidase: impact on ligand binding, redox chemistry, and interconversion of redox intermediates. J Biol Chem. 282(23):17041-52
M ZEDERBAUER, PG FURTMÜLLER, M BELLEI, J STAMPLER, C JAKOPITSCH, G BATTISTUZZI, Nicole MOGUILEVSKY, C OBINGER
2007
The vinyl-sulfonium bond in human myeloperoxidase: impact on compound I formation and reduction by halides and thiocyanate. Biochem Biophys Res Commun. 356(2):450-6.
M ZEDERBAUER, PG FURTMÜLLER, B GANSTER, Nicole MOGUILEVSKY, C OBINGER
2007
Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs: flufenamic acid and its 5-chloro-derivative directly interact with a recombinant human myeloperoxidase to inhibit the synthesis of hypochlorous acid. : Eur J Pharmacol.570(1-3):235-43.
P VAN ANTWERPEN, F DUFRASNE, M LEQUEUX, K BOUDJELTIA ZOUAOUI, I LESSGYER, S BABAR, P MOREAU, Nicole MOGUILEVSKY, M VANHAEVERBEEK, J DUCOBU, J NÈVE
2007
Presence of LDL Modified by Myeloperoxidase in the Penis in Patients with Vascular Erectile Dysfunction: A Preliminary Study. Eur Urol 51(1):262-9; discussion 268-9.
K ZOUAOUI BOUDJELTIA, T ROUMEGUERE, P DELREE, Nicole MOGUILEVSKY, J DUCOBU, M VANHAEVERBEEK, E WESPES
2006
Triggering of inflammatory response by myeloperoxidase-oxidized LDL, in Biochemistry and Cell Biology, volume 84, pp. 805-812
K ZOUAOUI BOUDJELTIA, I LEGSSYER, P VAN ANTWERPEN, RL KISOKA, S BABAR, Nicole MOGUILEVSKY, P DELREE, J DUCOBU, C REMACLE, M VANHAEVERBEEK, D BROHEE
2006
Antigens and granularity of blood monocytes in relation to inflammatory markers and lipids in postmenopausal women., in Maturitas. 55 : 132-141, volume 55, issue 2, pp. 132-141
K ZOUAOUI BOUDJELTIA, C GREGOIR, M GUILLAUME, C REMACLE, P PIRO, C GARBAR, J DUCOBU, Nicole MOGUILEVSKY, M VANHAEVERBEEK, P DELREE, D BROHEE
2006
Captopril inhibits the oxidative modification of apolipoprotein B-100 caused by myeloperoxydase in a comparative in vitro assay of angiotensin converting enzyme inhibitors. Eur. Pharmacol. 537: 31-6, in European Journal of Pharmacology, volume 537, issue 1-3, pp. 31-36
P VAN ANTWERPEN, I LEGSSYER, K ZOUAOUI BOUDJELTIA, S BABAR, P MOREAU, Nicole MOGUILEVSKY, M VANHAEVERBEEK, J DUCOBU, J NÈVE
2006
The pleiotropic effect of statins in haemodialysis patients is not the consequence of an inhibition of LDL oxidation by myeloperoxidase., in Nephrol Dial Transplant. , volume 9, pp. 2672-2674
P VAN ANTWERPEN, K ZOUAOUI BOUDJELTIA, M VAES, S BABAR, P MADHOUN, Nicole MOGUILEVSKY, M VANHAEVERBEEK, J NEVE, J DUCOBU
2006
Expression, purification, and structural prediction of the Ets transcription factor ERM., in Biochimica Biophysica Acta. , volume 1760, issue 8, pp. 1192-1201
S MAUEN, I HUVENT, V RAUSSENS, D DEMONTE, JL BAERT, C TRICOT, JM RUYSSCHAERT, C VAN LINT, Nicole MOGUILEVSKY, Y DE LAUNOIT
2005
Sites of covalent attachment of CYP4 enzymes to heme: evidence for microheterogeneity of P450 heme orientation, in Biochemistry 2005, volume 44, issue 42, pp. 13914-13920
BAER BR, SCHUMAN JT, CAMPBELL AP, CHEESMAN MJ, NAKANO M, Nicole MOGUILEVSKY, KUNZE KL, RETTIE AE
2005
Role of the covalent glutamic acid 242-heme linkage in the formation and reactivity of redox intemediates of human myeloperoxidase, in Biochemistry , volume 44, issue 17, pp. 6482-6491
M. ZEDERBAUER, W. JANTSCHKO, K. NEUGSCHWANDTER, C. JAKOPITSCH, Nicole MOGUILEVSKY, C. OBINGER, P.G. FURTMULLER
2004
Thiol-ccontaining molecules directly interact with myeloperoxidase to inhibit LDL oxidation. Biochem. Biophys. Res. Commun., in Biochemical and Biophysical Research Communications , volume 325, issue 2, pp. 434-438
Pierre VAN ANTWERPEN, Karim ZOUAOUI BOUDJELTIA, Sajida BABAR, Ilham LESSGYER, Patrick MOREAU, Nicole MOGUILEVSKY, Michel VANHAEVERBEEK, J. DUCOBU, Jean NEVE
2004
Oxidation of low density lipoproteins by myeloperoxidase at the surface of endothelial cells: an additional mechanism to subendothelium oxidation. Biochem. Biophys. Res. Commun. 325: 434-438.
Karim ZOUAOUI BOUDJELTIA, Nicole MOGUILEVSKY, Ilham LEGSSYER, Sajida BABAR, Michel GUILLAUME, Paul DELRÉE, Michel VANHAEVERBEEK, Dany BROHEE, Jean DUCOBU, Claude REMACLE
2004
Monoclonal antibodies against progressively oxidized LDL by myeloperoxidase react with ApoB-100 protein moiety and human atherosclerotic lesions. Biochem.Biophys.Res.Commun.323:1223-1228
Nicole MOGUILEVSKY, Karim ZOUAOUI BOUDJELTIA, Sajida BABAR, Paul DELRÉE, Ilham LEGSSYER, Yvon CARPENTIER, Michel VANHAEVERBEEK, Jean DUCOBU
2003
Identification of CDH1 germline mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Human Molecular Genetics 12:575-582.
G SURIANO, C OLIVEIRA, P FERREIRA, JC MACHADO, MC BORDIN, O DE WEVER, EA BRUYNEEL, Nicole MOGUILEVSKY, N GREHAN, TR PORTER, FM RICHARDS, RH HRUBAN, F ROVIELLO, D HUNTSMAN, M MAREEL, F CARNEIRO, C CALDAS, R SERUCA
2003
Organic and inorganic substrates as probes for comparing native bovine lactoperoxidase and recombinant human myeloperoxidase. J. Inorg. Biochem. 94: 146-154.
E GHIBAUDI, E LAURENTI, C PACCHIARDO, G SURIANO, Nicole MOGUILEVSKY, RP FERRARI
2003
Apolipoprotein L-I is the trypanosome lytic factor of human serum, and is blocked by SRA in Trypanosoma rhodesiense. Nature 422:83-87
L. VANHAMME, F PATURIAUX-HANOCQ, P POELVOORDE, D.P. NOLAN, L LINS, J VAN DEN ABBEELE, A PAYS, P TEBABI, H VAN XONG, A JACQUET, Nicole MOGUILEVSKY, Marc DIEU, J KANE, P DE BATSELIER, R BRASSEUR, E PAYS
2002
Alveolar macrophage activation by myeloperoxidase: a model for exacerbation of lung inflammation. Am. J. Respir. Cell Mol. Biol. 26 :716-722
K GRATTENDICK, R STUART, E ROBERTS, J LINCOLN, SS LEFKOWITZ, A BOLLEN, Nicole MOGUILEVSKY, H FRIEDMAN, DL LEFKOWITZ
2002
Binding characteristics of Cetirizine and Levocetirizine to human H1 histamine receptors: contribution of Lys191 and Thr194. Mol. Pharmacol. 61: 391-399.
M GILLARD, C VAN DER PERREN, Nicole MOGUILEVSKY, R MASSINGHAM, P CHATELAIN
2002
The antiviral activity of human recombinant myeloperoxidase on human cytomegalovirus. J. Med.Virology 66: 218-223.
K EL MESSAOUDI, AM VERHEYDEN, L THIRY, S FOUREZ, N TASIAUX, A BOLLEN, Nicole MOGUILEVSKY
2002
Major role for the carboxylic function of cetirizine and levocetirizine in their binding characteristics to human H1-histamine-receptors. Inflamm.Res. 51, S1: 79-80.
M GILLARD, C VAN DER PERREN, Nicole MOGUILEVSKY, R MASSINGHAM, P CHATELAIN
2001
Use of a recombinant human enzyme to investigate the inhibition of the myeloperoxidase chlorinating activity by non steroidal anti-inflammatory drugs. Eur. J. Pharmacol. 417 :37-43.
J NÈVE, N PARIJ, Nicole MOGUILEVSKY
2001
Native and recombinant proteins to analyze auto-antibodies to myeloperoxidase in pauci-immune crescentic glomerulonephritis. J. Immunol. Methods 254 : 47-58.
MM BOOMSMA, CA STEGEMAN, WW OOST-KORT, CG KALLENBERG, Nicole MOGUILEVSKY, PC LIMBURG, JW COHEN TERVAERT
2001
Glu375Gln and Asp225Val mutants: about the nature of the covalent linkages between heme group and apo-protein in bovine lactoperoxidase. Bioorg. Med. Chem. Lett. 11 : 2827-2831.
G SURIANO, S WATANABE, EM GHIBAUDI, A BOLLEN, RP FERRARI, Nicole MOGUILEVSKY
2001
A transient-kinetics study on the reactivity of monomeric, unprocessed recombinant myeloperoxidase. FEBS. Lett. 503: 147-150
PG FURTMÜLLER, W JANTSCHKO, G REGELSBERGER, C JAKOPITSCH, Nicole MOGUILEVSKY, C OBINGER
2000
Sequences (103-110) and (116-120) of the rat secretin receptor are implicated in secretin and VIP recognition. Ann. N.Y. Acad Sci. 921: 362-365.
P ROBBERECHT, E DI PAOLO, Nicole MOGUILEVSKY, A BOLLEN, M WAELBROECK
2000
Bovine lactoperoxidase and its recombinant: comparison of structure and some biochemical properties. Biochem. Biophys. Res. Commun. 11:756-761.
S WATANABE, S MURATA, H KUMURA, S NAKAMURA, A BOLLEN, Nicole MOGUILEVSKY, K SHIMAZAKI
2000
A human milk factor suceptible to cathepsin D inhibitors enhances human immunodeficiency virus type 1 infectivity and allows virus entry into a mammary epithelial cell line. J. Virol 74:1004-7.
K EL MESSAOUDI, LF THIRY, C LIESNARD, N VAN THIEGHEM, A BOLLEN, Nicole MOGUILEVSKY
2000
The endothelium and cytokine secretion : the role of peroxidases as immunoregulators. Cell. Immunol. 25: 23-30.
DL LEFKOWITZ, E ROBERTS, K GRATTENDICK, C SCHWAB, R STUART, J LINCOLN, RC ALLEN, Nicole MOGUILEVSKY, A BOLLEN, SS LEFKOWITZ
1999
Mutations of aromatic residues in the first transmembrane helix impair signalling by the secretin receptor. Receptors Channels, 6: 309-315.
E DI PAOLO, H PÉTRY, Nicole MOGUILEVSKY, A BOLLEN, P DE NEEF, M WAELBROECK, P WAELBROECK
1999
Characterisation of the Asp94 and Glu242 mutants in myeloperoxidase, the residues linking the heme group via ester bonds . Eur. J. Biochem. 264: 211-217.
I KOOTER, Nicole MOGUILEVSKY, A BOLLEN, NM SIJTSEMA, C OTTO, HL DEKKER, R WEVER
1999
The sulfonium ion linkage in myeloperoxidase : direct spectroscopic detection by isotopic labeling and effect of mutation. J. Biol. Chem 274: 26794-26802.
I KOOTER, Nicole MOGUILEVSKY, A BOLLEN, LA VAN DER VEEN, C OTTO, HL DEKKER, R WEVER
1999
HIV-1 infectivity and host range modification by cathepsin D, present in human vaginal secretions. AIDS, 13:333-339
K EL MESSAOUDI, L THIRY, N VAN TIEGHEM, C LIESNARD, Y ENGLERT, Nicole MOGUILEVSKY, A BOLLEN
1999
The Met243 sulfonium ion linkage is responsible for the anomalous magnetic circular dichroism and optical spectral properties of myeloperoxidase. J. Biol. Inorg. Chem 4 :684-691.
IM KOOTER, BP KOELHER, Nicole MOGUILEVSKY, A BOLLEN, R WEVER, MK JOHNSON
1999
Properties of a recombinant human secretin receptor : a comparison with the rat and rabbit receptors. Pancreas, 19: 51-55.
E DI PAOLO, P DE NEEF, Nicole MOGUILEVSKY, H PETRY, J CNUDDE, A BOLLEN, M WAELBROECK, P ROBBERECHT
1999
Role of charged amino acids conserved in the vasoactive intestinal polypeptide/secretin family of receptors on the secretin receptor functionality. Peptides 20: 1187-1193.
E DI PAOLO, JP VILARDAGA, H PETRY, Nicole MOGUILEVSKY, A BOLLEN, P ROBBERECHT, M WAELBROECK
1999
Neutrophilic myeloperoxidase-macrophage interactions perpetuate chronic inflammation associated with experimental arthritis. Clin. Immunol. 91:145-155.
DL LEFKOWITZ, MP GELDERMAN, RS FUHRMAN, S GRAHAM, JT STARNES, K GRATTENDICK, SS LEFKOWITZ, A BOLLEN, Nicole MOGUILEVSKY
1998
Augmentation of macrophage candidacidal capacity by recombinant human myeloperoxidase and granulocyte - macrophage colony stimulating factor. Infect. Immun. 66 : 2750-2754
L MARODI, C TOURNAY, R KAPOSZTA, RB Jr. JOHNSTON, E NAGY, Nicole MOGUILEVSKY
1998
Exposure of macrophages to an enzymatically inactive macrophage mannose receptor ligand augments killing of Candida albicans. Proc. Soc. Exp. Biol. Med. 217: 81-88
M.P. GELDERMAN, DL LEFKOWITZ, S.S. LEFKOWITZ, A BOLLEN, Nicole MOGUILEVSKY
1998
Recombinant bovine lactoperoxidase as a tool to study the heme environment in mammalian peroxidases. FEBS Letters, 441: 476-479
S WATANABE, F VARSALONA, Y-C YOO, J.P. GUILLAUME, A BOLLEN, K SHIMAZAKI, Nicole MOGUILEVSKY
1998
Contribution of the second transmembrane helix of the secretin receptor to the positioning of secretin. FEBS Letters. 424 : 207-210
E. DI PAOLO, P. DE NEEF, Nicole MOGUILEVSKY, H. PÉTRY, A. BOLLEN, M. WAELBROECK, P. ROBBERECHT
1997
Site-directed mutagenesis of Met243, a residu of myeloperoxidase involved in binding of the prosthetic group J. Biol. Inorg. Chem. 2 : 191-197.
I. KOOTER, Nicole MOGUILEVSKY, A. BOLLEN, N.M. SIJTSEMA, C. OTTO, R. WEVER
1997
Enhancement of macrophage-mediated bactericidal activity by macrophage-mannose receptor ligand interaction. Immunology and Cell Biology .: 75 : 136-141
D.L. LEFKOWITZ, J.A. LINCOLN, S.S. LEFKOWITZ, A. BOLLEN, Nicole MOGUILEVSKY
1997
Anti native and recombinant myeloperoxidase monoclonals and human autoantibodies. Clin. Exp. Immunol. 107 : 127-134
M.A.P. AUDRAIN, A.R. BARANGER, Nicole MOGUILEVSKY, S.J. MARTIN, A. DEVY, C.M. LOCKWOOD, J.Y. MULLER, V.L.M. ESNAULT
1997
Difference Fourier transform infrared evidence for ester bonds linking the heme group in myeloperoxidase, lactoperoxidase and eosinophil peroxidase J. Am. Chem. Soc. 47 : 11542-43
I.M. KOOTER, A.J. PIERIK, M. MERKX, B.A. AVERILL, Nicole MOGUILEVSKY, A. BOLLEN, R. WEVER
1996
Mutagénèse du récepteur H1 humain et design de nouveaux agents antihistaminiques. J. Pharmacol. Belg. 51, 155-160.
E. DIFFERDING, M. GILLARD, Nicole MOGUILEVSKY, F. VARSALONA, M. NOYER, J. DALIER, S. GOLDSTEIN, M. NEUWELS, M.A. LASSOIE, J.P. GUILLAUME, M. BASCOUR, A. BOLLEN, J.P. HÉNICHART
1996
Uptake of recombinant myeloperoxidase, free or fused to Fc'', by macrophage enhances killing activity toward micro-organisms. DNA and Cell Biology 15 : 617-24
C. TOURNAY, J.P. COURTOY, L. MARODI, P. TOTTÉ, A. JACQUET, L. GARCIA-QUINTANA, A. BOLLEN, Nicole MOGUILEVSKY
1996
Phagocytosis and intracellular killing of Candida albicans by macrophages exposed to myeloperoxidase. J. Infect. Dis. 173: 1202-1207
S.S. LEFKOWITZ, M.P. GELDERMAN, A. CASTRO, D.L. LEFKOWITZ, Nicole MOGUILEVSKY, A. BOLLEN
1995
Exogenous myeloperoxidase enhances bacterial phagocytosis and intracellular killing by macrophages. Infect. Immun. 63: 3042-3047
J. LINCOLN, D.L. LEFKOWITZ, T. CAIN, A. CASTRO, K. MILLS, S. LEFKOWITZ, Nicole MOGUILEVSKY, A. BOLLEN
1995
Heme-protein interaction in myeloperoxidase: modification of spectroscopic properties and catalytic activity by single residue mutation. J. Am. Chem. Soc. 117: 3907-3912
R. FLORIS, Nicole MOGUILEVSKY, G. PUPPELS, A. JACQUET, R. RENIRIE, A. BOLLEN, R. WEVER
1995
Neutrophil and recombinant myeloperoxidase as antigens in ANCA positive systemic vasculitis. Clin. Exp. Immunol. 102: 106-111
A. SHORT, M. LOCKWOOD, A. BOLLEN, Nicole MOGUILEVSKY
1995
Neutrophils-macrophage interaction: A paradigm for chronic inflammation. Med. Hypotheses 44: 58-62.
D.L. LEFKOWITZ, A. CASTRO, K. MILLS, S.S. LEFKOWITZ, A. BOLLEN, Nicole MOGUILEVSKY
1995
Pharmacological and functional characterisation of the wild-type and site-directed mutants of the human H1 histamine receptor stably expressed in CHO cells. J. Recept. Signal Transduct. Res. 15: 91-102.
Nicole MOGUILEVSKY, F. VARSALONA, J.P. GUILLAUME, M. NOYER, M. GILLARD, J. DALIERS, J.P. HÉNICHART, A. BOLLEN
1994
Stable expression of human H1 histamine receptor cDNA in chinese hamster ovary cells: pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene. Eur. J. Biochem. 224: 489-495.
Nicole MOGUILEVSKY, F. VARSALONA, M. NOYER, M. GILLARD, J.P. GUILLAUME, L. GARCIA, C. SZPIRER, J. SZPIRER, A. BOLLEN
1994
Site directed mutagenesis of human myeloperoxidase: further identification of residues involved in catalytic activity and heme interaction. Biochem. Biophys. Res. Comm. 202: 73-81.
A. JACQUET, L. GARCIA-QUINTANA, V. DELEERSNYDER, R. FENNA, A. BOLLEN, Nicole MOGUILEVSKY
1994
Hypotheses for a reevaluation of peroxidase activity in the oral inflammation NAD(P)H-dependant hypohalite reduction in human neutrophils. Acta Stomatologica Belgica 91: 73-81.
P. COURTOIS, A. VANDEN ABBEELE, Nicole MOGUILEVSKY, N. AMRANI, M. POURTOIS
1994
Myeloperoxidase mediated virucidal effect on human immunodeficiency virus type 1- infected cells. Antimicrob. Agents Chemotherapy 38: 969-972
J. CHOCHOLA, Y. YAMAGUCHI, Nicole MOGUILEVSKY, A. BOLLEN, D. STROSBERG, M. STANISLAWSKI
1994
Correct in vivo processing of a chimeric ubiquitin-proapolipoprotein A-I fusion protein in baculovirus-infected insect cells. J. Biotechnology 32: 39-43.
Nicole MOGUILEVSKY, J.P. GUILLAUME, F. VARSALONA, M. BULINCKX, A. BOLLEN
1993
Production of authentic human proapolipoprotein A-I in Escherichia coli: strategies for the removal of the amino-terminal methionine. J. Biotechnology 27: 159-172.
Nicole MOGUILEVSKY, F. VARSALONA, J.P. GUILLAUME, P. GILLES, A. BOLLEN, C. ROOBOL
1993
Candidicidal activity of human recombinant myeloperoxidase. Antimicrob. Agents Chemotherapy 37: 142-143.
C. TOURNAY, P. MAJERUS, M. POURTOIS, Nicole MOGUILEVSKY, A. BOLLEN
1993
Recombinant human myeloperoxidase stimulates the production of cytokines and induces macrophage-mediated cytotoxicity. Immun. Letters 36: 43-50
D.L. LEFKOWITZ, K.C. MILLS, Nicole MOGUILEVSKY, A. BOLLEN, A. VAZ, D. MORGAN, S.S. LEFKOWITZ
1992
Site-directed mutants of human myeloperoxidase : a topological approach to the heme-binding site. FEBS Letters 302: 189-191.
A. JACQUET, V. DELEERSNYDER, L. GARCIA-QUINTANA, A. BOLLEN, Nicole MOGUILEVSKY
1992
Lethal oxidative damage to human immunodeficiency virus in vitro by human recombinant myeloperoxidase. FEBS Letters 302: 209-212.
Nicole MOGUILEVSKY, C. THIRIART, M. STEENS, J.P. PRIEELS, L. THIRY, A. BOLLEN
1991
Spectral and enzymatic properties of human recombinant myeloperoxidase: comparison with mature enzyme. Arch. Biochem. Biophys. 291: 132-138.
A. JACQUET, J. PINCEMAIL, M. MATHY, Nicole MOGUILEVSKY, G. DEBY-DUPONT, A. THIRION, E. GOORMAGHTIGH, L. GARCIA-QUINTANA, A. BOLLEN, C. DEBY
1991
Structural and biological properties of biologically active human recombinant myeloperoxidase produced by Chinese Hamster Ovary cells in culture. Eur. J. Biochem. 197: 605-614.
Nicole MOGUILEVSKY, L. GARCIA-QUINTANA, A. JACQUET, C. TOURNAY, L. FABRY, L. PIÉRARD, A. BOLLEN
1989
Production of human recombinant apolipoprotein A-I in Escherichia coli: purification and biochemical characterization. DNA, 8: 429-436.
Nicole MOGUILEVSKY, C. ROOBOL, R. LORIAU, J.P. GUILLAUME, P. JACOBS, A. CRAVADOR, A. HERZOG, L. BROUWERS, A. SCARSO, P. GILLES, L. HOLMQUIST, L.A. CARLSON, A. BOLLEN
1987
Lactoferrin uptake and iron processing into macrophages: a study in familial haemochromatosis. British J. Haematol., 66: 129-136
Nicole MOGUILEVSKY, P.L. MASSON, P.J. COURTOY
1987
Study of the siderophores and receptors in different clinical isolates of Pseudomonas aeruginosa. Antibiot. Chemother., 39: 290-306.
P. CORNELIS, Nicole MOGUILEVSKY, J.F. JACQUES, P.L. MASSON
1985
Comparison of human lactoferrins from milk and neutrophilic leucocytes: relative molecular mass, isoelectric point, iron-binding properties and uptake by the liver. Biochem. J. 229: 353-359.
Nicole MOGUILEVSKY, L.A. RETEGUI, P.L. MASSON
1984
Uptake of lactoferrin by the liver. I. Role of the reticuloendothelial system as indicated by blockade experiments. Lab. Invest., 50:323-328.
L.A. RETEGUI, Nicole MOGUILEVSKY, C.E. CASTRACANE, P.L. MASSON
1984
Uptake of lactoferrin by the liver. III. Critical role of the protein moiety. Lab. Invest., 50: 335-339.
Nicole MOGUILEVSKY, L.A. RETEGUI,, P.J. COURTOY, C.E. CASTRACANE, P.L. MASSON
1984
Uptake of lactoferrin by the liver. II. Endocytosis by sinusoidal cells. Lab. Invest., 50:329-334.
P.J. COURTOY, Nicole MOGUILEVSKY, L.A. RETEGUI, C.E. CASTRACANE, P.L. MASSON
1981
Plasma protein synthesis in experimental liver cirrhosis (morphological demonstration and functional correlations). Lab. Invest., 45: 67-76.
J.P. COURTOY, G. FELDMANN, E. ROGIER, Nicole MOGUILEVSKY
1981
Synchronous increase of four acute phase proteins synthesized by the same hepatocyte during the inflammatory reaction (a combined biochemical and morphological kinetic study in the rat). Lab. Invest., 44: 105-115.
P.J. COURTOY, C. LOMBART, G. FELDMANN, Nicole MOGUILEVSKY, E. ROGIER

Thèses

1987
La lactoferrine: interaction avec le système réticuloendothélial en relation avec le métabolisme du fer
Nicole MOGUILEVSKY