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Membre du personnel

Bernard MASEREEL

Professeur ordinaire - Doyen

Téléphone: 081/724338
Fax: 081/724299
Mail:

Charges aux FUNDP

Diplômes

Pharmacien (1987) - Pharmacien d'Industrie (1988) - Master in Drug Design (1991) - Docteur en Sciences Pharmaceutiques (1993)

Domaines de compétences

Medicinal Chemistry - Organic synthesis - Pharmacology - Drug analysis

Charges externes

Membre du Collège des Experts de la Société Scientifique des Pharmaciens Francophones

Membre de la Société Belge des Sciences Pharmaceutiques

Membre du Bureau de Chimie Médicinale de la Société Royale de Chimie

Membre de la Société Belge de Physiologie et Pharmacologie Fondamentale et Clinique

Membre et Conseiller du Bureau de la Société de Chimie Thérapeutique (France)

Membre de l'American Chemical Society (USA)

Distinctions

Prix Boehringer Ingelheim pour la Recherche Fondamentale sur la Thrombose et l'Hémostase (2001)

Prix Galien (1994)

Prix de la Société de Chimie Thérapeutique (1993)

Chevalier de l'Ordre de la Couronne

Cours (titulaire)

Projets en cours

Anciens projets

Activités organisées

Colloque : Small Molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry (Leuven, Katholieke Universiteit Leuven, 2008)
Colloque : New Drugs and Drug Candidates: Recent Achievements in Medicinal Chemistry (Braine l'Alleud, UCB, 2007)

The Medicinal Chemistry Division of SRC (Société Royale de Chimie) and the Division for Medicinal and Bio-Organic Chemistry of KVCV (Koninklijke Vlaamse Chemische Vereniging) are organizing every year an international symposium in Belgium, with the aim to update interested participants on selected areas of pharmaceutical research, by specialists in their respective field.

This conference of six plenary lectures, three oral communications and a poster session will cover in particular hot topics and recent disclosures of how medicinal chemistry contributed to the identification of development compounds.

This one day symposium is scheduled to be held on Friday October 26, 2007, at UCB's R&D Site in Braine-l'Alleud, just outside of Brussels.

Colloque : XXIèmes Journées franco-belges de Pharmacochimie (Namur, FUNDP, 2007)
Colloque : Personnalized Medicine: New opportunities for Drug Discovery (Antwerp, 2006)

Anyone working in healthcare or drug discovery has undoubtedly heard about personalized medicine. Its most common definition is "the right drug for the right patient in the right dose." This refers to a future day when all healthcare decisions will be based on each person's genetic profile. For sure, this will have implications for medicinal chemistry and drug discovery: How to choose targets and design drugs for a population of patients with a specific genetic profile?

This one day symposium of six plenary lectures, oral communications and a poster session will cover various aspects of personalized medicine.

Colloque : XXèmes Journées Franco-Belges de Pharmacochimie (Lille, France, 2006)
Colloque : Drug Analysis (Namur, FUNDP, 2006)
Colloque : Rational Lead Profiling : Myth or Reality. (Namur, FUNDP, 2005)
Colloque : XIXèmes Journées Franco-Belges de Pharmacochimie. (Liège, 2005)
Colloque : Lead profiling : myth or reality (Gent, 2004)
Colloque : XVIIIèmes Journées Franco-Belges de Pharmacochimie. (Luxembourg, 2004)
Colloque : Structure-Based Drug Design (Louvain-La-Neuve, 2003)
Colloque : XVIIèmes Journées Franco-Belges de Pharmacochimie (Bruxelles, 2003)
Colloque : Drug Hunting : New targets, New tools, New drugs (Louvain-la-Neuve, 2002)
Colloque : XVIèmes Journées Franco-Belges de Pharmacochimie (Bagnoles de l'Orne, France, 2002)
Colloque : Drug Discovery Strategies : from leads to drugs (Louvain-la-Neuve, 2001)
Colloque : XVèmes Journées Franco-Belges de Pharmacochimie (Namur, FUNDP, 2001)
Colloque : Drug Discovery Strategies : hit and lead finding (Louvain-la-Neuve, 2000)
Colloque : XIVèmes Journées Franco-Belges de Pharmacochimie (Lille, France, 2000)
Colloque : XIIIèmes Journées Franco-Belges de Pharmacochimie (Liège, 1999)

Activités avec contribution

Formation : « Anticoagulants », Master en Drug Design (Lille, France, 2008)
Colloque : Les antibiotiques, optimiser la délivrance. Formation continuée destinée aux pharmaciens d'officine organisée par la Société Scientifique des Pharmaciens Francophones (SSPF (Bruxelles, Namur, Liège, Mons, Arlon, Nivelles), 2008)

Administrés parfois à tort et à travers, le bon usage des antibiotiques est régulièrement évoqué. Après un bref rappel des différentes classes d'antibiotiques, leurs indications, leur restriction d'usage, leurs interactions, les associations d'antibiotiques, les principaux effets indésirables, leur schéma thérapeutique (durée, moment de prise,...) seront également évoqués. Enfin, le choix des antibiotiques en voyage, ceux réservés à l'usage externe, et la place des probiotiques seront abordés."

Colloque : Quoi de neuf en vaccination ? (SSPF (Bruxelles, Liège, Mons, Namur, Nivelles, Luxembourg), 2007)

Formation continuée destinées aux pharmaciens d'officine organisée par la Société Scientifique des Pharmaciens Francophones.

Colloque : Revue critique des nouveaux médicaments de 2001 à 2005 (SSPF (Arlon, Bruxelles, Charleroi, Liège, Mons, Namur, Nivelles), 2006)

Au cours des cinq dernières années, 121 nouvelles entités chimiques ont été commercialisées en Belgique au sein de spécialités pharmaceutiques à usage humain. Cinq d'entre-elles ont déjà été retirées du marché. Parmi les 116 molécules restant en circulation, trente d'entre-elles ont un usage hospitalier exclusif, tandis qu'une trentaine de molécules sont d'origine biosynthétique.

Les critères permettant d'évaluer l'intérêt et l'apport d'un nouveau principe actif sont multiples. Parmi ces critères nous retiendrons essentiellement :

(i) le traitement d'une pathologie pour laquelle il n'existe jusqu'alors aucune autre alternative médicamenteuse,

(ii l'action du principe actif sur une cible nouvelle (récepteur, enzyme,...) impliquée dans l'étiologie d'une pathologie dont l'approche thérapeutique existe déjà par un autre mécanisme,

(iii) l'augmentation de l'efficacité,

(iv) l'amélioration du profil d'effets indésirables,

(v) la diminution du nombre d'interactions médicamenteuses,

(vi) une amélioration de la compliance

(vii) un moindre coût économique de cette nouvelle molécule par rapport aux autres substances appartenant à la même classe pharmaco-thérapeutique.

Cet exposé permettra une approche objective des innovations médicamenteuses et de leur bénéfice thérapeutique réel.

Colloque : Les Nouveaux Médicaments 2004 (SSPF (Bruxelles, Liège, Arlon, Mons, Charleroi, Namur), 2005)
Colloque : Les Nouveaux Médicaments 2003 (SSPF (Namur, Bruxelles, Liège, Arlon, Mons, Charleroi), 2004)

Activités avec simple participation

Formation : Anticoagulants, "Master in Drug Design" (, 2007)
Colloque : Les nouveaux Médicaments 2002 (SSPF (Luxembourg, Mons, Liège, Nivelles), 2003)

Publications (312)

2009
Potential nanotoxicity in blood : Effects of engineered nanoparticles on human blood constituents, in Nanofac 2009
Julie LALOY, Catherine MARBEHANT, Severine ROBERT, François MULLIER, Bernard CHATELAIN, Jean-Michel DOGNÉ, Olivier TOUSSAINT, Bernard MASEREEL, Stéphanie ROLIN

Contributions à des ouvrages collectifs

2009
Dual carbonic anhydrase and cyclooxygenase-2 inhibition, in Drug Design of zinc-enzyme inhibitors, collection Drug Discovery & Development. , pp. 255-272
Jean-Michel DOGNÉ, Anne THIRY, Bernard MASEREEL, Claudiu SUPURAN
2009
Drug design of carbonic anhydrase inhibitors as anticonvulsant agents., in Drug-Design of Zinc-Enzyme inhibitors, collection Drug Discovery & Development. , pp. 171-191
Anne THIRY, Jean-Michel DOGNÉ, Claudiu SUPURAN, Bernard MASEREEL
1992
Action of diuretics at the cellular level., in Progress in Pharmacology and Clinical Pharmacology, volume 9, pp. 23-32
E LOHRMANN, Bernard MASEREEL, R NITSCHKE, B PIROTTE, J DELARGE, R GREGER
1991
The mode of action of diuretics., in Nephrology, volume 2, pp. 1072-1081
Emmanuel LOHRMANN, R NITSCHKE, RB NITSCHKE, I BURHOFF, Bernard MASEREEL, Bernard PIROTTE, E SCHLATTER, Jjacques DELARGE, HJ LANG, HC ENGLERT, M SALOMONSSON, AE PERSSON, O EIDELMAN, ZI CABANTTCHIK, Rainer GREGER

Articles de périodique

2012
Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase, in Proceedings of the National Academy of Sciences, PNAS 2012 ; published ahead of print January 30, 2012, doi:10.1073/pnas.1113873109
Luc PILOTTE, Pierre LARRIEU, Vincent STROOBANT, Didier COLAU, Eduard DOLUSIC, Raphael FRÉDÉRICK, Etienne DE PLAEN, Catherine UYTTENHOVE, Johan WOUTERS, Bernard MASEREEL, Benoit VAN DEN EYNDE
2011
Effects of the dispersion methods in Pluronic F108 on the size and the surface composition of MWCNTs and their implications in toxicology assessment, in Journal of Nanoparticule Research, volume 13, issue 2, pp. 655-667
Jorge Humberto MEJIA MENDOZA, Frans TICHELAAR, Christelle SAOUT, Olivier TOUSSAINT, Bernard MASEREEL, Zineb MEKHALIF, Stephane LUCAS, Joseph DELHALLE
2011
Surface properties and cell adhesion onto allylamine-plasma and amine-plasma coated glass coverslips, in Journal of Material Science : Materials in Medicine, volume 22, pp. 671-682
Marianne CRESPIN, Nicolas MOREAU, Bernard MASEREEL, Olivier FERON, Bernard GALLEZ, Thierry VANDER BORGHT, Carine MICHIELS, Stephane LUCAS
2011
Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors, in Bioorganic & medicinal chemistry, volume 19, pp. 134-144
Jérémy RENIERS, Severine ROBERT, Raphael FRÉDÉRICK, Bernard MASEREEL, Stephane VINCENT, Johan WOUTERS
2011
Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indenol[1,2-c]pyridazin-5-one derivatives, in European journal of medicinal chemistry, volume 46, pp. 6104-6111
Jérémy RENIERS, Céline MEINGUET, Laurence MOINEAUX, Bernard MASEREEL, Stephane VINCENT, Raphael FRÉDÉRICK, Johan WOUTERS
2011
BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase - doi:10.1016/j.prostaglandins.2011.03.001, in Prostaglandins & other Lipid Mediators, volume 94, pp. 124-132
Céline CHERDON, Stéphanie ROLIN, Julien HANSON, Annie OOMS, Laurence DE LEVAL, Pierre DRION, Carine MICHIELS, Bernard PIROTTE, Bernard MASEREEL, Natzi SAKALIHASSAN, Jean-Olivier DEFRAIGNE, Jean-Michel DOGNÉ
2011
Development of a PIXE analysis method for the determination of the biopersistence of SiC and TiC nanoparticles in rat lungs, in Nanotoxicology
Omar LOZANO GARCIA, Jorge Humberto MEJIA MENDOZA, Bernard MASEREEL, Olivier TOUSSAINT, Dominique LISON, Stephane LUCAS
2011
Anti-virulence strategy against Brucella suis: Synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors. doi: 10.1039/C10B05149K, in Organic and Biomolecular Chemistry
Jean-Yves WYNUM, KOHLER, JOSEPH, ABDO, Jérémie MORTIER, TURTAUT, Jean-Louis MONTERO, Bernard MASEREEL
2011
Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors, in Bioorganic & Medicinal Chemistry, volume 19, issue 4, pp. 1550-1561
Eduard DOLUSIC, Pierre LARRIEU, Sébastien BLANC, Frédéric SAPUNARIC, Bernadette NORBERG, Laurence MOINEAUX, Delphine COLETTE, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Thierry FERAIN, Graeme FRASER, Moreno GALLENI, Jean-Marie FRÈRE, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2011
BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase. doi: 10.1016/j.prostaglandins.2011.03.001, in Prostaglandins and Other Lipid Mediators
Céline CHERDON, Stéphanie ROLIN, Julien HANSON, OOMS, Laurence DE LEVAL, Pierre DRION, Marcelle MICHIELS, Bernard PIROTTE, Bernard MASEREEL, SAKALIHASSAN, DEFRAIGNE, Jean-Michel DOGNÉ
2011
Carbon nanoparticles synthesized by sputtering and gas condensation inside a nanocluster source of fixed dimenson. doi: 10.1016/j.surfcoat.2011.03.055, in Surface and Coatings Technology, volume 205, pp. S577-S580
Virginie BOUCHAT, Olivier FERON, Bernard GALLEZ, Bernard MASEREEL, Carine MICHIELS, Thierry VANDER BORGHT, Stephane LUCAS
2011
Tryptophan 2,3-dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators, in Journal of Medicinal Chemistry, volume 54, issue 15, pp. 5320-5334
Eduard DOLUSIC, Pierre LARRIEU, Laurence MOINEAUX, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Lionel POCHET, Benoît VAN DEN EYNDE, Bernard MASEREEL, Johan WOUTERS, Raphael FRÉDÉRICK
2011
On the use of radioisotopes to study the possible synthesis by magnetron sputtering of bimetallic nanoparticles , in Surface & coatings Technology, volume 205, issue 21-22, pp. 4934-4940
Valérie BOUCHAT, Nicolas MOREAU, Vanessa VALEMBOIS, Kamel ABBAS, Olivier FERON, Bernard GALLEZ, Uwe HOLZWARTZ, Bernard MASEREEL, Carine MICHIELS, Federica SIMONELLI, Thierry VANDER BORGHT, Stephane LUCAS
2011
Discovery and preliminary SARs of Keto-Indoles as Novel Indoleamine 2,3-Dioxygenase (IDO) Inhibitors, in European Journal of Medicinal Chemistry, volume 46, issue 7, pp. 3058-3065
Eduard DOLUSIC, Pierre LARRIEU, Sébastien BLANC, Frédéric SAPUNARIC, Jenny POUYEZ, Laurence MOINEAUX, Delphine COLETTE, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Thierry FERAIN, Graeme FRASER, Moreno GALLENI, Jean-Marie FRÈRE, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2011
Validation of the calibrated thrombin generation test (cTGT) as the reference assay to evaluate the procoagulant activity of nanomaterials. doi: 10.3109/17435390.2011.569096, in Nanotoxicology
Julie LALOY, Severine ROBERT, Catherine MARBEHANT, François MULLIER, Jorge Humberto MEJIA MENDOZA, Jean-Pascal PIRET, Stephane LUCAS, Bernard CHATELAIN, Jean-Michel DOGNÉ, Olivier TOUSSAINT, Bernard MASEREEL, Stéphanie ROLIN
2011
Differential toxicity of copper (II) oxide nanoparticles of similar hydrodynamic diameter on human differentiated intestinal CaCo-2 cells is correlated to copper release and specific area/shape. Comparison to multi-walled carbon nanotubes, in Nanotoxicology
Jean-Pascal PIRET, Sebastien VANKONINGSLOO, Jorge Humberto MEJIA MENDOZA, Nicolas NOEL, Emmanuelle BOILAN, Françoise LAMBINON, Bernard MASEREEL, Joseph DELHALLE, Stephane LUCAS, Christelle SAOUT, Marie-Christine JACQUES-TOUSSAINT
2011
Chemical reactivity of Plasma Polymerized Allylamine (PPAA) thin films on Au and Si: study of the thickness influence and ageing of the films, in Surface and Coatings Technology, volume 205, issue 2, pp. S462-S465
Nicolas MOREAU, Olivier FERON, Bernard GALLEZ, Bernard MASEREEL, Carine MICHIELS, Thierry VANDER BORGHT, François ROSSI, Stephane LUCAS
2010
Effects of the dispersion methods in Pluronic F108 on the size and the surface composition of MWCNTs and their implications in toxicology assessment, in J Nanoparts Res, DOI 10 1007/s11051-010-0063-7
Jorge MEJIA, Frans TICHELAAR, Christelle SAOUT, Olivier TOUSSAINT, Bernard MASEREEL, Zineb MEKHALIF, Stephane LUCAS, Joseph DELHALLE
2010
Design, solid-phase synthesis and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors, in Bioorganic and Medicinal Chemistry, volume 18, issue 21, pp. 7392-7401
Sébastien GLUSZOK, Raphael FRÉDÉRICK, Catherine FOULON, Frédérique KLUPSCH, Claudiu SUPURAN, Daniela VULLO, Andrea SCOZZAFAVA, Jean-François GOOSSENS, Bernard MASEREEL, Patrick DEPREUX, Laurence GOOSSENS
2010
Antibody immobilization on gold nanoparticles coated layer-by-layer with polyelectrolytes (http://dx.doi.org/10.1007/s11051-010-9908-3), in Journal of Nanoparticle Research, volume 13, issue 4, pp. 1573-1580
Bernard MASEREEL, Mustapha DINGUIZLI, Nicolas MONIOTTE, Caroline BOUZIN, Olivier FERON, Bernard GALLEZ, Thierry VAN DER BORGHT, Carine MICHIELS, Stephane LUCAS
2010
Radioimmunotherapy with radioactive nanoparticles: Biological doses and treatment efficiency for vascularized tumors with or without a central hypoxic area, in Medical Physics
Virginie BOUCHAT, Olivier FERON, Bernard GALLEZ, Bernard MASEREEL, Carine MICHIELS, Vincent NUTTENS, Thierry VANDER BORGTH, Stephane LUCAS
2010
NF-kappaB inducing kinase (NIK) inhibitors: identification of new scaffolds using virtual screening , in Bioorganic and Medicinal Chemistry Letters, volume 20, issue 15, pp. 4515-4520
Jérémie MORTIER, Bernard MASEREEL, Caroline REMOUCHAMPS, Corinne GANEFF, Jacques PIETTE, Raphael FRÉDÉRICK
2010
Radioimmunotherapy with radioactive nanoparticles: Biological doses and treatment efficiency for vascularized tumors with or without a central hypoxic area, in Medical Physics, volume 37, issue 4, pp. 1826-1839
V. BOUCHAT, Carine MICHIELS, Bernard MASEREEL, O. FERON, B. GALLEZ, T. VANDER BORGHT, Stephane LUCAS
2010
Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NK-κB activation, in Biochemical pharmacology, volume 79, pp. 1462-1472
Jérémie MORTIER, Raphael FRÉDÉRICK, Corinne GANEFF, Caroline REMOUCHAMPS, Patrice TALAGA, Lionel POCHET, Johan WOUTERS, Jacques PIETTE, Emmanuel DEJARDIN, Bernard MASEREEL
2010
Dispersion of multi-walled carbon nanotubes in biocompatible dispersants, in J. Nanoparts Res., volume 12, issue 1, pp. 75-82
Jean-Pascal PIRET, Simon DETRICHE, Renaud VIGNERON, Sebastien VANKONINGSLOO, Stéphanie ROLIN, Jorge Humberto MEJIA MENDOZA, Bernard MASEREEL, Stephane LUCAS, Joseph DELHALLE, Frédéric LUIZI, Christelle SAOUT, Olivier TOUSSAINT
2010
Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins, in Journal of Medicinal Chemistry, volume 53, pp. 335-344
Alfonso MARESCA, Claudia TEMPERINI, Lionel POCHET, Bernard MASEREEL, Andrea SCOZZAFAVA, Claudiu SUPURAN
2009
Carbon nanoparticles synthetized by sputtering and gaz condensation aggregation technique
Virginie BOUCHAT, Olivier FERON, Bernard GALLEZ, Bernard MASEREEL, Carine MICHIELS, Thierry VANDER BORGHT, Stephane LUCAS
2009
Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?, in Pharmacological Research, volume 59, issue 3, pp. 160-166
Severine ROBERT, Jérémie GHIOTTO, Bernard PIROTTE, Jean-Louis DAVID, Bernard MASEREEL, Lionel POCHET, Jean-Michel DOGNÉ
2009
Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors, in Bioorganic and Medicinal Chemistry, volume 17, pp. 553-557
Anne THIRY, Marie LEDECQ, Alessandro CECCHI, Raphael FRÉDÉRICK, Jean-Michel DOGNÉ, Johan WOUTERS, Bernard MASEREEL, Claudiu T. SUPURAN
2009
Synthesis and biological evaluation of a new family of anti-benzylanilinosulfonamides as CA IX inhibitors, in European journal of medicinal chemistry, volume 44, pp. 511-518
Anne THIRY, Aurélie DELAYEN, Laurence GOOSSENS, Raymond HOUSSIN, Marie LEDECQ, Aurélie FRANKART, Jean-Michel DOGNÉ, Johan WOUTERS, Claudiu T. SUPURAN, Jean-Pierre HENICHART, Bernard MASEREEL
2009
PVD Synthesis and Transfer into Water-Based Solutions of Functionalized Gold Nanoparticles, in Plasma Processes and Polymers, volume 6, issue 1, pp. s888-s892
Nicolas MOREAU, Carine MICHIELS, Bernard MASEREEL, Olivier FERON, Bernard GALLEZ, Thierry VANDER BORGHT, Stephane LUCAS
2009
Conception et synthèse d'indanesulfonamides en tant qu'inhibiteurs originaux des anhydrases carboniques, in Chimie Nouvelle, issue 100, pp. 22-25
Anne THIRY, Jean-Michel DOGNÉ, Bernard MASEREEL
2008
Carbonic anhydrase inhibitors: Binding of indanesulfonamides to the human isoform II, in ChemMedChem, volume 3, issue 3, pp. 473-477
Katia D'AMBROSIO, Bernard MASEREEL, Anne THIRY, Andréa SCOZZAFAVA, Claudiu SUPURAN, Giuseppina DE SIMONE
2008
Anticonvulsant sulfonamides/sulfamates/sulfamides with carbonic anhydrase inhibitory activity: drug design and mechanism of action, in Current Pharmaceutical Design, volume 14, issue 7, pp. 661-671
Anne THIRY, Jean-Michel DOGNÉ, Claudiu T. SUPURAN, Bernard MASEREEL
2008
Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs, in Journal of Medicinal Chemistry, volume 51, issue 11, pp. 3051-3056
Anne THIRY, Claudiu T. SUPURAN, Bernard MASEREEL, Jean-Michel DOGNÉ
2008
Carbonic anhydrase inhibitors: Bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII, in Journal of Medicinal Chemistry, volume 51, issue 11, pp. 3230-3237
Katia D'AMBROSIO, Rosa-Maria VITALE, Jean-Michel DOGNÉ, Bernard MASEREEL, Alessio INNOCENTI, Andréa SCOZZAFAVA, Giuseppina DE SIMONE, Claudiu SUPURAN
2008
Production and preliminary characterization of DC plasma polymerized allylamine film (PPAA) by NRA, ERD, and XPS, in Nuclear instruments and methods in physics research. B, volume 266, pp. 2494-2497
Stephane LUCAS, Gilles GENARD, Carine MICHIELS, Bernard MASEREEL, Olivier FERON, Bernard GALLEZ, Thierry VANDER BORGHT, Nicolas MOREAU
2008
Synthesis and pharmacological evaluation of a new targeted drug carrier system: beta-cyclodextrin coupled to oxytocin, in Bioorganic and Medicinal Chemistry Letters, volume 18, issue 6, pp. 1855-1858
Carine BERTOLLA, Stéphanie ROLIN, Brigitte EVRARD, Lionel POCHET, Bernard MASEREEL
2008
Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors, in Journal of Medicinal Chemistry, volume 51, pp. 3077-3081
Severine ROBERT, Carine BERTOLLA, Bernard MASEREEL, Jean-Michel DOGNÉ, Lionel POCHET
2008
Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation, in European journal of medicinal chemistry, volume 43, pp. 2853-2860
Anne THIRY, Stéphanie ROLIN, Daniela VULLO, Aurélie FRANKART, Andrea SCOZZAFAVA, Jean-Michel DOGNÉ, Johan WOUTERS, Claudiu T. SUPURAN, Bernard MASEREEL
2007
Exploration of the binding mode of indanesulfonamides as selective inhibitors of human carbonic anhydrase type VII by targeting Lys91, in ChemMedChem, volume 2, issue 9, pp. 1273-1280
Anne THIRY, Bernard MASEREEL, Jean-Michel DOGNÉ, Claudiu T. SUPURAN, Johan WOUTERS, Catherine MICHAUX
2007
Radioimmunotherapy with radioactive nanoparticles: first results of dosimetry for vascularised and necrosed solid tumors, in Medical physics, volume 34, issue 11, pp. 4504-4513
Virginie BOUCHAT, Vincent NUTTENS, Carine MICHIELS, Bernard MASEREEL, Olivier FÉRON, Bernard GALLEZ, Thierry VANDER BORGHT, Stephane LUCAS
2007
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX and XIV with sulfonamides incorporating fructopyranose-thioureido tails, in Bioorganic and Medicinal Chemistry Letters, volume 17, issue 10, pp. 2685-2691
Jean-Yves WINUM, Anne THIRY, Khaled EL CHEIKH, Jean-Michel DOGNÉ, Jean-Louis MONTERO, Daniela VULLO, Andrea SCOZZAFAVA, Bernard MASEREEL, Claudiu T. SUPURAN
2007
Carbonic anhydrase inhibitors as anticonvulsant agents, in Current Topics in Medicinal Chemistry, volume 7, issue 9, pp. 855-864
Anne THIRY, Jean-Michel DOGNÉ, Claudiu T. SUPURAN, Bernard MASEREEL
2007
Mechanism-Based Thrombin Inhibitors: Design, Synthesis, and Molecular Docking of a New Selective 2-Oxo-2H-1-benzopyran Derivative, in Journal of Medicinal Chemistry, volume 50, pp. 3645-3650
Raphael FRÉDÉRICK, Severine ROBERT, Caroline CHARLIER, Johan WOUTERS, Bernard MASEREEL, Lionel POCHET
2007
BM-520, an original TXA2 modulator, inhibits the action of thromboxane A2 and 8-iso-prostaglandin F2alpha in vitro and in vivo on human and rodent platelets, and aortic vascular smooth muscles from rodents, in Prostaglandins & Other Lipid Mediators, volume 84, issue 1-2, pp. 14-23
Stéphanie ROLIN, Julien HANSON, Caroline VASTERSHAEGHER, Céline CHERDON, Domenico PRATICO, Bernard MASEREEL, Jean-Michel DOGNÉ
2007
Dual carbonic anhydrase - Cyclooxygenase-2 inhibitors, in Current Topics in Medicinal Chemistry, volume 7, issue 9, pp. 885-891
Jean-Michel DOGNÉ, Anne THIRY, Domenico PRATICO, Bernard MASEREEL, Claudiu T. SUPURAN
2006
Revue critique des nouveaux principes actifs à usage humain commercialisés en Belgique au cours de la période 2001-2005, in Journal de Pharmacie de Belgique, volume 61, issue 2, pp. 45-57
Bernard MASEREEL
2006
Investigation of mechanism-based thrombin inhibitors: implications of a highly conserved water molecule for the binding of coumarins within the S pocket, in Bioorganic and Medicinal Chemistry Letters, volume 16, issue 7, pp. 2017-2021
Raphael FRÉDÉRICK, Caroline CHARLIER, Severine ROBERT, Johan WOUTERS, Bernard MASEREEL, Lionel POCHET
2006
Indanesulfonamides as carbonic anhydrase inhibitors: toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX, in Journal of Medicinal Chemistry, volume 49, issue 9, pp. 2743-2749
Anne THIRY, Marie LEDECQ, Alessandro CECCHI, Jean-Michel DOGNÉ, Johan WOUTERS, Claudiu T. SUPURAN, Bernard MASEREEL
2006
Prostanoid as pharmacological targets in COPD and asthma, in European Journal of Pharmacology, volume 533, pp. 89-100
Stéphanie ROLIN, Bernard MASEREEL, Jean-Michel DOGNÉ
2006
Synthesis, molecular modelling and enzymatic evaluation of (±) 3,5-diphenyl-2-thioxoimidazolidin-4-ones as new potential cyclooxygenase inhibitors, in Bioorganic and Medicinal Chemistry, volume 14, issue 4, pp. 918-927
Marie-Pierre GAUTHIER, Catherine MICHAUX, Stéphanie ROLIN, Caroline VASTERSAEGHER, Xavier DE LEVAL, Fabien JULÉMONT, Lionel POCHET, Bernard MASEREEL
2006
Targeting tumor-associated carbonic anhydrase IX in cancer therapy, in Trends in Pharmacological Sciences, volume 27, issue 11, pp. 566-573
Anne THIRY, Jean-Michel DOGNÉ, Bernard MASEREEL, Claudiu T. SUPURAN
2006
Evaluation of BM-573, a novel TXA2 synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion, in Prostanglandins and Other Lipid Mediators, volume 79, issue 1-2, pp. 53-73
Philippe KOLH, Stéphanie ROLIN, Vincent TCHANA-SATO, Michel PÉTEIN, Alexandre GHUYSEN, Bernard LAMBERMONT, Julien HANSON, David MAGIS, Patrick SEGERS, Bernard MASEREEL, Vincent D'ORIO, Jean-Michel DOGNÉ
2005
Characterization of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig, in Thrombosis Research, volume 116, issue 5, pp. 431-442
Jean-Michel DOGNÉ, Marie-Pierre ROLIN, Michel PETEIN, Vincent TCHANA-SATO, Alexandre GHUYSEN, Bernard LAMBERMONT, Julien HANSON, David MAGIS, Patrick SEGERS, Bernard PIROTTE, Bernard MASEREEL, Pierre DRION, Vincent D'ORIO, Philippe KOLH
2005
Effects of reperfusion on left ventricular hemodynamics and ventriculo-arterial coupling in acutely ischemic pigs, in Computer Methods in Biomechanics and Biomedical Engeineering, volume 8, pp. 169-170
Lieve LANOYE, Philippe KOLH, Stéphanie ROLIN, Vincent TCHANA-SATO, Jean-Michel DOGNÉ, Alexandre GHUYSEN, Bernard LAMBERMONT, David MAGIS, Julien HANSON, Patrick SEGERS, P GERARD, Bernard MASEREEL, Vincent D'ORIO, Raymond LIMET
2005
In vitro and in vivo pharmacological characterization of BM-613, a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in Journal of Pharmacology and Experimental Therapeutics, volume 313, issue 1, pp. 293-301
Julien HANSON, Stéphanie ROLIN, D REYNAUD, N QIAO, L KELLEY, H REID, F VALENTIN, J TIPPINS, T KINSELLA, Bernard MASEREEL, C PACE-ASCIAK, Bernard PIROTTE, Jean-Michel DOGNÉ
2005
3,6-disubstituted coumarins as mechanism based inhibitors of Thrombin and Factor Xa, in Journal of Medicinal Chemistry, volume 48, pp. 7592-7603
Raphael FRÉDÉRICK, Severine ROBERT, Caroline CHARLIER, Jerome DE RUYCK, Johan WOUTERS, Bernard PIROTTE, Bernard MASEREEL, Lionel POCHET
2005
Pharmacological profile and therapeutic potential of BM-573, a combined thromboxane receptor antagonist and synthase inhibitor, in Cardiovascular Drug Reviews, volume 23, pp. 1-14
Alexandre GHUYSEN, Jean-Michel DOGNÉ, Patrice CHIAP, Stéphanie ROLIN, Bernard MASEREEL, Bernard LAMBERMONT, Philippe KOHL, Vincent TCHANA-SATO, Julien HANSON, Vincent DORIO
2005
Modulators of the coagulation cascade: Focus and Recent Advances in Inhibitors of Tissue Factor, Factor VIIa and their complex, in Current Medicinal Chemistry, volume 12, issue 4, pp. 397-417
Raphael FRÉDÉRICK, Lionel POCHET, Caroline CHARLIER, Bernard MASEREEL
2005
Nouveaux principes actifs commercialisés en 2004 au sein de spécialités pharmaceutiques à usage humain, in Journal de Pharmacie de Belgique, volume 60, pp. 1-16
Bernard MASEREEL
2004
New developments on thromboxane modulators, in Mini-Reviews in Medecinal Chemistry, volume 4, pp. 649-657
Jean-Michel DOGNÉ, Julien HANSON, Xavier DE LEVAL, Bernard MASEREEL, Philippe KOHL, Bernard PIROTTE
2004
Effect of a novel thromboxane A2 inhibitor on right ventricular-arterial coupling in endotoxic shock, in Shock, volume 21, issue 1, pp. 45-51
Bernard LAMBERMONT, Philippe KOHL, Alexandre GHUYSEN, Patrick SEGHERS, Jean-Michel DOGNÉ, Vincent TCHAN-SATO, Philippe MORIMONT, Patricia BENOIT, P GERARD, Bernard MASEREEL, Vincent D'ORIO
2004
Coumarins and isocoumarins as serine protease inhibitors, in Current Pharmaceutical Design, volume 10, pp. 3781-3796
Lionel POCHET, Raphael FRÉDÉRICK, Bernard MASEREEL
2004
Pharmacological evaluation of both enantiomers of (R,S)-BM-591 as thromboxane A2 receptor antagonists and thromboxane synthase inhibitors, in Prostaglandins & Other Lipid Mediators, volume 74, pp. 75-86
Stéphanie ROLIN, Jean-Michel DOGNÉ, Caroline VASTERSAEGHER, Julien HANSON, Bernard MASEREEL
2004
Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity, in Bioorganic and Medicinal Chemistry, volume 12, issue 10, pp. 2717-2726
Marc ILIES, Bernard MASEREEL, Stéphanie ROLIN, Andrea SCOZZAFAVA, G CAMPEANU, V CIMPEANU, Claudiu SUPURAN
2004
New developments on thromboxane and prostacyclin modulators part II: prostacyclin modulators, in Current Medicinal Chemistry, volume 11, issue 10, pp. 1243-1252
Xavier DE LEVAL, Julien HANSON, Jean-Louis DAVID, Bernard MASEREEL, Bernard PIROTTE, Jean-Michel DOGNÉ
2004
New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators, in Current Medicinal Chemistry, volume 11, issue 10, pp. 1223-1241
Jean-Michel DOGNÉ, Xavier DE LEVAL, Julien HANSON, Michel FREDERICH, Bernard LAMBERMONT, Alexandre GHUYSEN, Angela CASINI, Bernard MASEREEL, KH RUAN, Bernard PIROTTE, Philippe KOLH
2004
Pharmacological Characterization of N-tert-Butyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a Novel Thromboxane A2 Receptor Antagonist and Thromboxane Synthase Inhibitor in a Rat Model of Arterial Thrombosis and Its Effects, in Journal of Pharmacology and Experimental Therapeutics, volume 309, issue 2, pp. 498-505
Jean-Michel DOGNÉ, Julien HANSON, Xavier DE LEVAL, Philippe KOHL, Vincent TCHANA-SATO, Laurence DE LEVAL, Stéphanie ROLIN, Alexandre GHUYSEN, Patrick SEGERS, Bernard LAMBERMONT, Bernard MASEREEL, Bernard PIROTTE
2004
Carbonic anhydrase inhibitors - Design of anticonvulsant sulfonamides incorporating indane moieties, in Bioorganic and Medicinal Chemistry Letters, volume 14, pp. 5781-5786
Celine CHAZALETTE, Bernard MASEREEL, Stéphanie ROLIN, Anne THIRY, Andrea SCOZZAFAVA, Alessio INNOCENTI, Claudiu T. SUPURAN
2004
Nouvelles entités chimiques entrant dans la composition de spécialités commercialisées en Belgique en 2003, in Journal de Pharmacie de Belgique, volume 59, issue 1, pp. 1-12
Bernard MASEREEL
2003
Nouveaux principes actifs entrant dans la composition de spécialités pharmaceutiques commercialisées en 2002, in Journal de Pharmacie de Belgique, volume 58, pp. 1-20
Bernard MASEREEL
2003
Effects of U-46619 on pulmonary hemodynamics before and after administration of BM-573, a novel thromboxane A2 inhibitor, in Arch Physiol Biochem, volume 111, issue 3, pp. 217-223
Bernard LAMBERMONT, Phillipe KOHL, Jean-Michel DOGNÉ, Alexandre GHUYSEN, Vincent TCHANA-SATO, Philippe MORIMONT, Patricia BENOIT, P GÉRARD, Bernard MASEREEL, Raymond LIMET, Vincent D'ORIO
2003
BM-573, a Dual Thromboxane Synthase Inhibitor and Thromboxane Receptor Antagonist Prevents Pig Myocardial Infarction Induced by Coronary Thrombosis, in Journal of Pharmacology and Experimental Therapeutics, volume 306, pp. 59-65
Stéphanie ROLIN, Michel PETEIN, Vincent TCHANA-SATO, Jean-Michel DOGNÉ, Patricia BENOIT, Bernard LAMBERMONT, Alexandre GHUYSEN, Philippe KOHL, Bernard MASEREEL
2003
Effects of endotoxic shock on right ventricular systolic function and mechanical efficiency, in Cardiovascular Research, volume 59, pp. 412-418
Bernard LAMBERMONT, A GHUYSEN, Philippe KOLH, Vincent TCHANA-SATO, P SEGERS, P GÉRARD, Philippe MORIMONT, D MAGIS, Jean-Michel DOGNÉ, Bernard MASEREEL, Vincent D'ORIO
2003
3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo, in British Journal of Cancer, volume 88, pp. 1111-1118
Isabelle KEMPEN, D PAPAPOSTOLOU, Nicole THIERRY, Lionel POCHET, Stéphane COUNEROTTE, Bernard MASEREEL, Jean-Michel FOIDART, Michèle REBOUD-RAVAUX, Agnès NOEL, Bernard PIROTTE
2003
A pharmacophore model for sulphonyl-urea (-cyanoguanidine) compounds with dual action, thromboxane receptor antagonists and thromboxane synthase inhibitors, in European Journal of Medicinal Chemistry, volume 38, pp. 703-710
Catherine MICHAUX, Jean-Michel DOGNÉ, Stéphanie ROLIN, Bernard MASEREEL, Johan WOUTERS, François DURANT
2003
Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II): effects of BM-567 on platelet function, in Prostaglandins Leukotrienes and Essential Fatty Acids, volume 68, pp. 49-54
Jean-Michel DOGNÉ, Xavier DE LEVAL, Philippe KOHL, V. SANNA, Stéphanie ROLIN, Catherine MICHAUX, M. MAUER, Jean-Louis DAVID, Bernard MASEREEL, Bernard PIROTTE
2003
An overview of inhibitors of Na+/H+ exchanger, in European Journal of Medicinal Chemistry, volume 38, pp. 547-554
Bernard MASEREEL, Lionel POCHET, Didier LAECKMANN
2003
Pharmacological evaluation of the novel thromboxane modulator BM-567 (II/II). Effects of BM-567 on osteogenic sarcoma-cell-induced platelet aggregation, in Prostaglandins Leukotrienes and Essential Fatty Acids, volume 68, pp. 55-59
Xavier DE LEVAL, Valérie BENOIT, Jacques DELARGE, Fabien JULÉMONT, Bernard MASEREEL, Benard PIROTTE, Marie-Paule MERVILLE, Jean-Louis DAVID, Jean-Michel DOGNÉ
2003
Investigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry, in Tetrahedron, volume 59, pp. 4557-4561
Lionel POCHET, Marc DIEU, Raphael FRÉDÉRICK, Anne-Marie MURRAY, Isabelle KEMPEN, Bernard PIROTTE, Bernard MASEREEL
2002
Recent advances in antiplatelet agents, in Current Medicinal Chemistry, volume 9, pp. 577-589
Jean-Michel DOGNÉ, Xavier DE LEVAL, P BENOÎT, Jacques DELARGE, Bernard MASEREEL, Jean-Louis DAVID
2002
Synthesis and biological evaluation of aroylguanidines related to amiloride as inhibitors of the human platelet Na+/H+ exchanger, in Bioorganic & Medicinal Chemistry, volume 10, issue 6, pp. 1793-1804
Didier LAECKMANN, Françoise ROGISTER, Jean-Victor DEJARDIN, Christelle PROSPERI-MEYS, Joseph GÉCZY, Jacques DELARGE, Bernard MASEREEL
2002
Structural approach of the mechanism of inhibition of a-chymotrypsin by coumarins, in Bioorganic & Medicinal Chemistry Letters, volume 12, issue 7, pp. 1109-1112
Johan WOUTERS, Marjorie HUYGENS, Lionel POCHET, Bernard PIROTTE, François DURANT, Bernard MASEREEL
2002
New active agents. The composition of commercial pharmaceutical specialities in 2001, in Journal de Pharmacie de Belgique, volume 57, pp. 1-13
Bernard MASEREEL
2002
In vitro and in vivo effects of new insulin releasing agents, in Biochemical Pharmacology, volume 63, issue 3, pp. 515-521
Quynh-Anh NGUYEN, Marie-Hélène ANTOINE, Raogo OUEDRAOGO, Marcel HERMANN, Jacqueline SERGOORIS, Bernard PIROTTE, Bernard MASEREEL, Philippe LEBRUN
2002
K-ATP channel openers for the treatment of breast and endometrial cancer, in Expert opinion on Therapeutic Patents, volume 12, pp. 1111-1113
Bernard MASEREEL
2002
Therapeutic potential of thromboxane inhibitors in asthma, in Expert Opinion on Investigational Drugs, volume 11, pp. 1-8
Jean-Michel DOGNÉ , Xavier DE LEVAL, Patricia BENOIT, Stéphanie ROLIN, Bernard PIROTTE, Bernard MASEREEL
2002
Carbonic Anhydrase Inhibitors: Anticonvulsant Sulfonamides Incorporating Valproyl and Other Lipophilic Moieties, in Journal of Medicinal Chemistry, volume 45, pp. 312-320
Bernard MASEREEL, Stéphanie ROLIN, Francesco ABBATE, Andrea SCOZZAFAVA, Claudiu SUPURAN
2002
Thromboxane A2 inhibition : Therapeutic potential in bronchial asthma., in American Journal of Respiratory Medicine, volume 1, pp. 11-17
Jean-Michel DOGNÉ, Xavier DE LEVAL, Patricia BENOÎT, Jacques DELARGE, Bernard MASEREEL
2002
N-tert-Butyl-N'-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea, BM531, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition, in Acta crystallographica. Section C: Crystal structure communications, issue C58, pp. 621-623
Catherine MICHAUX, Jean-Michel DOGNÉ, Bernadette NORBERG, François DURANT, Bernard MASEREEL
2001
Design, synthesis and biological evaluation of a sulfonylcyanoguanidine as thromboxane A2 receptor antagonist and thromboxane synthase inhibitor, in Journal of Pharmacy and Pharmacology, issue 53, pp. 669-680
Jean-Michel DOGNÉ, Johan WOUTERS, Stéphanie ROLIN, Catherine MICHAUX, Lionel POCHET, François DURANT, Jacques DELARGE, Bernard MASEREEL
2001
Structure determination and comparison of BM567, a sulfonylurea, with Terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition, in Bioorganic and Medicinal Chemistry Letters, issue 11, pp. 1019-1022
Catherine MICHAUX, Stéphanie ROLIN, Jean-Michel DOGNÉ, François DURANT, Bernard MASEREEL, Jacques DELARGE, Johan WOUTERS
2001
Synthesis of nimesulide nanoparticles in the microemulsion epikuron/isopropyl myristate/water/n-butanol (or isopropanol), in Journal of Colloid and Interface Science, volume 243, pp. 90-101
Fabienne DEBUIGNE, Jérémie CUISENAIRE, Laurence JEUNIEAU, Bernard MASEREEL, Janos B.NAGY
2001
Novel inhibitors of sodium-calcium exchanger: benzene ring analogues of N-guanidino substituted amiloride derivatives., in European Journal of Medicinal Chemistry, volume 36, pp. 597-614
Françoise ROGISTER, Didier LAECKMANN, PO PLASMAN, F VAN EYLEN, M GHYOOT, C MAGGETTO, Jean-François LIÉGEOIS, Jozef GECZY, André HERCHUELZ, Jacques DELARGE, Bernard MASEREEL
2001
Recent developments of thromboxane modulators, in Expert Opinion on Therapeutic Patents, volume 11, pp. 1663-1675
Jean-Michel DOGNÉ, Xavier DE LEVAL, Jacques DELARGE, Bernard MASEREEL
2001
Activity of a novel dual thromboxane A2 receptor antagonist and thromboxane synthase inhibitor (BM-573) on platelet function and isolated smooth muscles., in Prostaglandins Leukotrienes and Essential Fatty Acids, volume 65, pp. 67-72
Stéphanie ROLIN, Jean-Michel DOGNÉ, Catherine MICHAUX, Jacques DELARGE, Bernard MASEREEL
2001
Nouveaux Médicaments. Principes actifs entrant dans la composition de spécialités pharmaceutiques commercialisées en 2000., in Journal de Pharmacie de Belgique, volume 56, pp. 1-32
Jeanine OSLET, Bernard MASEREEL
2001
Evaluation of classical NSAIDs and COX-2 selective inhibitors on purified ovine enzymes and human whole blood, in Prostaglandins Leukotrienes and Essential Fatty Acids, volume 64, pp. 211-216
Xavier DE LEVAL, Jacques DELARGE, Philippe DEVEL, Phillipe NEVEN, Catherine MICHAUX, Bernard MASEREEL, Bernard PIROTTE, Jean-Louis DAVID, Yves HENROTIN, Jean-Michel DOGNÉ
2001
Pharmacology of the thromboxane receptor antagonist and thromboxane synthase inhibitor BM-531, in Cardiovascular Drug Reviews, volume 19, pp. 87-96
Jean-Michel DOGNÉ, Stéphanie ROLIN, Xavier DE LEVAL, Phillipe NEVEN, Jacques DELARGE, Philippe KOLH, Jacques DAMAS, Jean-Louis DAVID, Bernard MASEREEL
2000
Coumarinic derivatives as mechanism-based inhibitors of &-chymotrypsin and human leukocyte elastase, in Bioorganic and Medicinal Chemistry, issue 8, pp. 1489-1501
Lionel POCHET, Caroline DOUCET, Georges DIVE, Johan WOUTERS, Bernard MASEREEL, Michèle REBOUD-RAVAUX, Bernard PIROTTE
2000
Comparison of the effects of nimesulide and nimesulide-L-lysine on PGE2 production by COX-1 and COX-2 and on chondrocyte metabolism in-vitro, in Pharmacy and Pharmacology Communication, volume 6, pp. 83-87
Xavier DE LEVAL, Yves HENROTIN, A LABASSE, Jean-Yves REGINSTER, Philippe NEVEN, Jacques DELARGE, Fabian SOMERS, Bernard MASEREEL, Bernard PIROTTE, Jean-Michel DOGNÉ
2000
Pharmacomodulation studies of torasemide led to original non-carboxylic thromboxane A2 receptor antagonists, in Pharmacy and Pharmacology Communication, volume 6, pp. 77-82
Jean-Michel DOGNÉ, Xavier DE LEVAL, Philippe NEVEN, Stéphanie ROLIN, Fabian SOMERS, Johan WOUTERS, Jacques DELARGE, Bernard MASEREEL
2000
Synthesis of monodisperse nimesulide nanoparticles in microemulsions E 170/isopropyl myristate/water/n-butanol (or isopropanol)., in Journal de Pharmacie de Belgique, volume 55, pp. 59-60
Fabienne DEBUIGNE, Jérémie CUISENAIRE, Laurence JEUNIEAU, Janos B.NAGY, Bernard MASEREEL
2000
Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition, in Acta crystallographica Section C: Crystal Structure communications, issue 56, pp. 1265-1266
Catherine MICHAUX, Bernadette NORBERG, Jean-Michel DOGNÉ, François DURANT, Bernard MASEREEL, Jacques DELARGE, Johan WOUTERS
2000
Effects of a novel non-carboxylic thromboxane A2 receptor antagonist (BM-531) derived from torasemide on platelet function, in Prostaglandins Leukotrienes and Essential Fatty Acids, volume 62, pp. 311-317
Jean-Michel DOGNÉ, Xavier DE LEVAL, Philippe NEVEN, Stéphanie ROLIN, Johan WOUTERS, Jean-Louis DAVID, Jacques DELARGE, Bernard MASEREEL
2000
Isosterism among analogues of torasemide: conformational, electronic and lipophilic properties, in European Journal of Medicinal Chemistry, volume 35, pp. 923-929
Johan WOUTERS, Catherine MICHAUX, François DURANT, Jean Michel DOGNÉ, Jacques DELARGE, Bernard MASEREEL
2000
Nouveaux principes actifs entrant dans la composition de spécialités pharmaceutiques commercialisées en 1999, in Journal de Pharmacie de Belgique, volume 55, pp. 1-29
Jeanine OSLET, Bernard MASEREEL
2000
New Trends in Thromboxane and Prostacyclin Modulators, in Current Medicinal Chemistry , volume 7, pp. 609-628
Jean-Michel DOGNÉ, Xavier DE LEVAL, Jacques DELARGE, Jean-Louis DAVID, Bernard MASEREEL
1999
Insulinotropic effect of new glibenclamide isosteres, in Journal of Pharmacology and Experimental Therapeutics, volume 289, pp. 625-631
R OUEDRAOGO, QA NGUYEN, Marie-Hélène ANTOINE, C KANE, MJ DUNNE, Lionel POCHET, Bernard MASEREEL, Philippe LEBRUN
1999
Thromboxane A2 receptor antagonism in man and rat by a sulphonylcyanoguanidine (BM-144) and a sulphonylurea (BM-500), in Journal of Pharmacy and Pharmacology, volume 51, pp. 695-701
Bernard MASEREEL, Jacques DAMAS, Jeanine FONTAINE, Martine LEMBÈGE, Fabrice LACAN, Alain NUHRICH, Jacques DELARGE, Lionel POCHET, Jean-Michel DOGNÉ
1999
Synthesis, structural characterization and thromboxane A2 receptor antagonistic activity of 3-substituted 2-[arylsulfonyl)imino]-2,3-dihydrothiazolyl derivatives., in European Journal of Medicinal Chemistry, volume 34, pp. 311-328
Fabrice LACAN, Martine VARACHE-LEMBÈGE, J VERCAUTEREN, JM LÉGER, Bernard MASEREEL, Jean-Michel DOGNÉ, Alain NUHRICH
1999
Antagonism of the TXA2 receptor by seratrodast: a structural approach, in Bioorganic and Medicinal Chemistry Letters, volume 9, pp. 2867-2870
Johan WOUTERS, François DURANT, Bernard MASEREEL
1999
Evidence for a neuroprotective effect of pyrid-3-yl-sulphonyl-urea in photochemically induced focal ischemia in rats : magnetic resonance imaging evaluation, in Journal of Pharmacy and Pharmacology, volume 51, pp. 967-970
C BAUDELET, R DEMEURE, A FROIS, Bernard MASEREEL, JF GOUDEMANT, C RITTER, Bernard GALLEZ
1999
BM 144: an original thromboxane A2 receptor antagonist derived from torasemide., in Journal de Pharmacie de Belgique, volume 54, pp. 57-58
Jean-Michel DOGNÉ, Philippe NEVEN, Jacques DAMAS, Jeanine FONTAINE, Stéphanie ROLIN, Xavier DE LEVAL, Jacques DELARGE, Bernard MASEREEL
1999
P-glycoprotein inhibition by glibenclamide and related compounds., in Pflugers Archiv / European Journal of Physiology, volume 437, pp. 652-660
PE GOLSTEIN, A BOOM, J VAN GEFFEL, P JACOBS, Bernard MASEREEL, Renaud BEAUWENS
1998
Design, Synthesis and Anticonvulsant Activity of 1-(Pyrid-3-ylsulfonamido)-2-nitroethylenes, in Journal of Medicinal Chemistry, volume 41, issue 17, pp. 3239-3244
Bernard MASEREEL, Johan WOUTERS, Lionel POCHET, Didier LAMBERT
1998
Pyridothiadiazinedioxides structurally related to quinazolinones cholecystokinin/gastrin receptor ligands : synthesis and biological evaluation, in European Journal of Pharmaceutical Sciences, volume 7, pp. 29-40
Bernard PIROTTE, Pascal DE TULLIO, Tchao PODONA, Ousman DIOUF, Daniel DEWALQUE, Philippe NEVEN, Bernard MASEREEL, Daniel Henri CAIGNARD, Pierre RENARD, Jacques DELARGE
1998
Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives, in Journal of Medecinal Chemistry, volume 41, pp. 1138-1145
H UCAR, K VAN DERPOORTEN , S CACCIAGUERRA, S SPAMPINATO, S STABLES, Paul DEPOVERE, M ISA, Bernard MASEREEL, Jacques DELARGE, Jacques POUPAERT
1998
Anticonvulsant Activity and Interactions with Neuronal Voltage-Dependent Sodium Channel of Analogues of Ameltolide, in Journal of Medicinal Chemistry, volume 41, pp. 3307-3313
Jacques VAMECQ, Didier LAMBERT, Jacques POUPAERT, Bernard MASEREEL, J.P. STABLES
1998
"Fries like" rearrangement : a novel and efficient method for the synthesis of 6-acyl-2(3H)-benzoxazolones and 6-acyl-2(3H)-benzothiazolones., in Tetrahedron, volume 54, pp. 1763-1772
H UCAR, K VAN DERPOORTEN, Paul DEPOVERE, Daniel LESIEUR, M ISA, Bernard MASEREEL, J. DELARGE, Jacques POUPAERT
1997
Synthesis and Biological Evaluation of Sulfonylcyanoguanidines and Sulfonamidonitroethylenes as Bioisosteres of Hypoglycemic sulfonylureas., in European Journal of Medicinal Chemistry, volume 32, pp. 453-456
Bernard MASEREEL, R OUEDRAOGO, Jean-Michel DOGNÉ, Marie-Hélène ANTOINE, Pascal DE TULLIO, Bernard PIROTTE, Lionel POCHET, Jacques DELARGE, Philippe LEBRUN
1997
Synthesis and biological evaluation of new 3-aralkylamino-2-aryl-2H-1,2,4-pyridothiadiazine 1,1-dioxides as potential CCK receptors ligands., in Journal of Pharmacy and Pharmacology, volume 49, pp. 463-471
Pascal DE TULLIO, Bernard PIROTTE, Philippe NEVEN, Bernard MASEREEL, Daniel DEWALQUE, Ousman DIOUF, Tchao PODONA, Daniel CAIGNARD, Pierre RENARD, Jacques DELARGE
1997
Anticonvulsant activity of pyrid-3-yl-sulfonyl urea and thiourea., in Epilepsia, volume 38, pp. 334-337
Bernard MASEREEL, Didier LAMBERT, Jean-Michel DOGNÉ, Jacques POUPAERT, Jacques DELARGE
1997
Pharmacomodulation studies of torasemide led to original diuretic, neuroprotective, anticonvulsant and antithrombotic drugs., in Journal de Pharmacie de Belgique, volume 52, pp. 157-158
Bernard MASEREEL, Jean-Michel DOGNÉ, Alain NUHRICH, Martine VARACHE-LEMBÈGE, Jeanine FONTAINE, Lionel POCHET, Fabian SOMERS, Pascal DE TULLIO, Bernard PIROTTE, Jacques DELARGE
1996
Bioavailability and anticonvulsant activity of 2-cyanoguanidinophenytoin, a structural analogue of phenytoin., in Journal of Pharmaceutical Sciences, volume 85, pp. 1077-1081
Didier LAMBERT, Bernard MASEREEL, Bernard GALLEZ, Murielle GEURTS, Gerhard SCRIBA
1996
Activation of ATP-dependent K+ Channels and Inhibition of Insulin Release: Effect of BPDZ 62., in Journal of Pharmacology and Experimental Therapeutics, volume 277, pp. 156-162
Philippe LEBRUN, Marie-Hélène ANTOINE, R OUEDRAOGO, C KANE, M DUNNE, M HERMANN, André HERCHUELZ, Bernard MASEREEL, Jacques DELARGE, Pascal DE TULLIO, Bernard PIROTTE
1996
First synthesis of 4-substituted-benzenesulfonylcyanoguanidines, in Tetrahedron Letters, volume 37, pp. 7253-7254
Bernard MASEREEL, Philippe LEBRUN, Jean-Michel DOGNÉ, Pascal DE TULLIO, Bernard PIROTTE, Lionel POCHET, Ousmane DIOUF, Jacques DELARGE
1996
3- and 4-substituted 4H-pyrido [4,3-e]-1,2,4-thiadiazine 1,1 dioxides as potassium channel openers: synthesis, pharmacological evaluation, and structure-activity relationships., in Journal of Medicinal Chemistry, volume 1996, pp. 937-948
Pascal DE TULLIO, Bernard PIROTTE, Philippe LEBRUN, Jeanine FONTAINE, Léon DUPONT, Marie-Hélène ANTOINE, R OUEDRAOGO, Smaïl KHELILI, C MAGGETTO, Bernard MASEREEL, Ousmane DIOUF, Tchao PODONA, Jacques DELARGE
1996
Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of alpha-chymotrypsin: Significance of the «aromatic» nature of the novel ester-type coumarin for strong inhibitory activity., in Journal of Medicinal Chemistry, volume 1996, pp. 2579-2585
Lionel POCHET, Caroline DOUCET, Marc SCHYNTS, N THIRRY, Nicole BOGGETTO, Bernard PIROTTE, KY JIANG, Bernard MASEREEL, Pascal DE TULLIO, Jacques DELARGE, Michèle REBOUD-RAVAUX
1996
The inhibitors of the Na+ 2Cl- K+ cotransporter, in Drugs of the Future, volume 21, pp. 185-190
Bernard MASEREEL, Jacques DELARGE
1995
3-Benzamido-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide., in Acta Crystallographica : section C, volume C51, pp. 1903-1905
Léon DUPONT, Pascal DE TULLIO, Bernard PIROTTE, Bernard MASEREEL, Jacques DELARGE
1995
Nimesulide., in Acta Crystallographica : section C, volume C51, pp. 507-509
Léon DUPONT, Bernard PIROTTE, Jacques DELARGE, Bernard MASEREEL, Josef GECZY
1995
N-Cyano-N'-Isopropyl-N"-((4-(3'Methylphenylamino)Pyrid-3-yl) Sulfonyl) Guanidine., in Acta Crystallographica : section C, volume C51, pp. 505-507
Léon DUPONT, Bernard MASEREEL, Pascal DE TULLIO, Bernard PIROTTE, Jacques DELARGE
1995
Synthesis and pharmacology of pyrid-3-yl sulfonylcyanoguanidines as diuretics., in European Journal of Medicinal Chemistry, volume 30, pp. 343-351
Bernard MASEREEL, Didier LAECKMANN, Léon DUPONT, Jean-François LIÉGEOIS, Bernard PIROTTE, Pascal DE TULLIO, Jacques DELARGE
1995
Synthesis and structural studies of a new class of heterocyclic compounds: 1,2,4 pyridothiadiazine 1,1-dioxides, pyridyl analogues of 1,2,4-benzothiadiazine 1,1-dioxides., in Tetrahedron, volume 51, pp. 3221-3234
Pascal DE TULLIO, Bernard PIROTTE, Léon DUPONT, Bernard MASEREEL, Didier LAECKMANN, Tchao PODONA, Ousman DIOUF, Philippe LEBRUN, Jacques DELARGE
1995
2-Cyanoimino-5,5-diphenyl-4-imidazoline monohydrate., in Acta Crystallographica : section C, volume C51, pp. 1901-1903
Léon DUPONT, Bernard MASEREEL, Didier LAMBERT, Gerhard SCRIBA
1995
BM 27 (monograph), in Annual Drug Data Report, volume 17, pp. 514-514
Bernard MASEREEL
1995
7-Méthyl-3-methylthio-4H-pyrido[4,3-e]-1,2,4-thiadiazin-7-ium-4-4-ide 1,1-dioxide zwitterion., in Acta Crystallographica : section C, volume C51, pp. 2416-2417
Léon DUPONT, Pascal DE TULLIO, Bernard PIROTTE, Bernard MASEREEL, Jacques DELARGE
1995
3,7-Diméthyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide., in Acta Crystallographica : section C, volume C51, pp. 2414-2416
Bernard MASEREEL, Léon DUPONT, Bernard PIROTTE, Pascal DE TULLIO, Jacques DELARGE
1995
2,4,7-trimethyl-2,3-dihydro-4H-pyrido[4,3]-e]-1,2,4thiadiazinium 1,1-dioxide iodide., in Acta Crystallographica : section C, volume C51, pp. 2412-2414
Bernard MASEREEL, Léon DUPONT, Pascal DE TULLIO, Ousman DIOUF, Jacques DELARGE
1995
3-Amino-4H-pyrido[4,3-e]-1,2,4 thiadiazine 1,1-dioxide monohydrate and 3-tert-Butylamino-4H-pyrido[4,3-e]-1,2,4 thiadiazine 1,1-dioxide., in Acta Crystallographica : section C, volume C51, pp. 1385-1388
Léon DUPONT, Bernard PIROTTE, Pascal DE TULLIO, Bernard MASEREEL, Jacques DELARGE
1995
3-Methyl-4H-pyrido[2,3-e]-1,2,4 thiadiazine 1,1 dioxide., in Acta Crystallographica : section C, volume C51, pp. 2064-2066
Léon DUPONT, Bernard PIROTTE, Pascal DE TULLIO, Bernard MASEREEL, Jacques DELARGE
1995
3-Methyl-4H-pyrido[4,3-e]-1,2,4 thiadiazine 1,1 dioxide monohydrate., in Acta Crystallographica : section C, volume C51, pp. 946-948
Léon DUPONT, Pascal DE TULLIO, Bernard PIROTTE, Bernard MASEREEL, Jacques DELARGE
1995
Les activateurs de canaux potassiques: étude structurale comparative du pinacidil, du diazoxide et du cromakalim., in Annales Pharmaceutiques Françaises, volume 53, pp. 201-208
Léon DUPONT, Bernard PIROTTE, Pascal DE TULLIO, Bernard MASEREEL, Jacques DELARGE
1995
Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor., in European Journal of Pharmacology, volume 1995, pp. R1-R3
Jean-François LIÉGEOIS, Jacques BRUHWYLER, Jacques DAMAS, Françoise ROGISTER, Bernard MASEREEL, Josef GECZY, Jacques DELARGE
1995
3-Methyl-4H-pyrido[3,2-e]-1,2,4 thiadiazine 1,1 dioxide, in Acta Crystallographica section C, volume C51, pp. 944-946
Léon DUPONT, Bernard PIROTTE, Pascal DE TULLIO, Bernard MASEREEL, Jacques DELARGE
1994
Synthesis and pharmacology of pyrid-3-yl sulfonylureas and sulfonylthioureas as inhibitors of the astrocytic Na+ 2Cl- K+ co-transporter., in European Journal of Medicinal Chemistry, volume 29, pp. 527-535
Bernard MASEREEL, Pierre RENARD, Marc SCHYNTS, Bernard PIROTTE, Pascal DE TULLIO, Jacques DELARGE
1993
Evaluation of the inhibitory activity on serine and aspartic proteases of 4-amino-4H-1,2,4-triazole and 5-aminothiazole derivatives structurally related to ß -lactam antibiotics., in Journal of Pharmacy and Pharmacology, volume 45, pp. 466-472
AC VILAIN, Bernard PIROTTE, I VERGELY, Nicole BOGGETTO, Bernard MASEREEL, Marc SCHYNTS, Jacques DELARGE, Michèle REBOUD-RAVAUX
1993
3-Alkylamino-4H-pyrido[4,3-e][1,2,4]thiadiazine 1,1 dioxides as powerful inhibitors of insulin release from rat pancreatic ß -cells: new perspectives in the study of potassium channels., in Journal of Medicinal Chemistry, volume 36, pp. 3211-3213
Bernard PIROTTE, Pascal DE TULLIO, Philippe LEBRUN, Marie-Hélène ANTOINE, Jeanine FONTAINE, Bernard MASEREEL, Marc SCHYNTS, Léon DUPONT, André HERCHUELZ, Jacques DELARGE
1993
4-Acylamino-4H-1,2,4-triazoles and related structures: new investigations of their chemical and physico-chemical properties associated to their particular exocyclic amide function., in Canadian Journal of Chemistry, volume 71, pp. 1857-1866
Bernard PIROTTE, Pascal DE TULLIO, Bernard MASEREEL, Marc SCHYNTS, Jacques DELARGE, Léon DUPONT, Léopold THUNUS
1993
A sulphonylthiourea (BM 20) related to torasemide, a new loop diuretic with relative potassium- sparing properties., in Journal of Pharmacy and Pharmacology, volume 45, pp. 720-724
Bernard MASEREEL, Marc SCHYNTS, Jean M KRZESINSKI, Bernard PIROTTE, Georges RORIVE, Jacques DELARGE
1993
Structural study of pinacidil, a potassium channel opener belonging to the N-alkyl, N"-cyano, N'-pyridylguanidine chemical class., in Helvetica Chimica Acta, volume 76, pp. 1311-1318
Bernard PIROTTE, Léon DUPONT, Pascal DE TULLIO, Bernard MASEREEL, Marc SCHYNTS, Jacques DELARGE
1993
Torasemide derivatives. New perspectives., in Cardiovascula Drug Review, volume 11, pp. 359-369
Bernard MASEREEL
1992
Design, synthesis and biological activity of a series of torasemide derivatives, potent blockers of the Na+ 2Cl- K+ cotransporter. In vitro study., in Journal of Pharmacy and Pharmacology, volume 44, pp. 589-593
Bernard MASEREEL, Emmanuel LOHRMANN, Marc SCHYNTS, Bernard PIROTTE, Rainer GREGER, Jacques DELARGE
1992
Synthèse, étude théorique et évaluation biologique de dérivés du 4-amino-4H-1,2,4,triazoles analogues de antibiotiques ß-lactamiques., in European Journal of Medicinal Chemistry, volume 27, pp. 193-205
Bernard PIROTTE, Georges DIVE, Jacques DELARGE, Bernard MASEREEL, Léon DUPONT, Léopold THUNUS, Marc SCHYNTS, Jean COYETTE, Jean-Marie FRÈRE
1992
Na+ 2Cl- K+ cotransport system as a marker of antihypertensive activity of new torasemide derivatives., in European Journal of Pharmacology, volume 219, pp. 385-394
Bernard MASEREEL, Patrizia FERRARI, Mara FERRANDI, Bernard PIROTTE, Marc SCHYNTS, Paolo PARENTI, Jacques DELARGE
1991
Structures du 1-((4-cycloheptylaminopyrid-3-yl)-sulfonyl) 3-cyclohexylurée et de l'hydrogénonitrate du 1-((4-cyclooctylaminopyrid-3-yl)-sulfonyl) 3-cyclohexylurée., in Acta Crystallographica : section C, volume C47, pp. 2152-2156
Léon DUPONT, Otto DIDEBERG, Bernard MASEREEL, Jacques DELARGE, Marc SCHYNTS, Bernard PIROTTE
1990
Les sulfamidés diurétiques, des origines aux perspectives d'avenir., in Chimie Nouvelle, volume 32, pp. 920-924
Bernard PIROTTE, Bernard MASEREEL, Marc SCHYNTS, Jacques DELARGE

Actes de colloques

2011
LECTURE: Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A, in Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, volume OC10, pp. 22-22
Eduard DOLUSIC, Pierre LARRIEU, Delphine COLETTE, Sébastien BLANC, Arnaud RIVES, Graeme FRASER, Johan WOUTERS, Robert KISS, Benoît VAN DEN EYNDE, Bernard MASEREEL, Evelyne DELFOURNE, Raphael FRÉDÉRICK
2011
coauthor on lecture: Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase (TDO): discovery of an orally active TDO inhibitor., in Book of Abstracts, Emerging Targets and Treatments: Opportunities and Challenges for Drug Design, Ghent, 25 November 2011, volume OC01
Eduard DOLUSIC, Pierre LARRIEU, Laurence MOINEAUX, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Benoît VAN DEN EYNDE, Bernard MASEREEL, Johan WOUTERS, Raphael FRÉDÉRICK
2011
Indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2,3-dioxygenase (IDO), a promising target for anti-cancer immunotherapy, in Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, volume P37, pp. 62-62
Eduard DOLUSIC, Pierre LARRIEU, Sébastien BLANC, Laurence MOINEAUX, Delphine COLETTE, Graeme FRASER, Vincent STROOBANT, Luc PILOTTE, Didier COLAUX, Johan WOUTERS, Bernard MASEREEL, Benoît VAN DEN EYNDE, Raphael FRÉDÉRICK
2011
Discovery and preliminary SARs of new scaffolds of tryptophan 2,3-dioxygenase (TDO) inhibitors using virtual screening, in Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, volume P19, pp. 44-44
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2011
THIOSEMICARBAZONES AS INHIBITORS OF TRYPTOPHAN 2,3-DIOXYGENASE (TDO), AN EMERGING TARGET FOR CANCER TREATMENT, in Book of Abstracts, Emerging Targets and Treatments: Opportunities and Challenges for Drug Design, Ghent, 25 November 2011, volume P21
Eduard DOLUSIC, Sara MODAFFARI, Pierre LARRIEU, Christelle VANCRAEYNEST, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Benoît VAN DEN EYNDE, Johan WOUTERS, Bernard MASEREEL, Raphael FRÉDÉRICK
2011
A CONVENIENT FORMATION OF HIGHLY FUNCTIONALIZED 5-BROMO-1,3-THIAZOLES., in Book of Abstracts, 15th Sigma-Aldrich Organic Synthesis Meeting, Spa, Belgium, 1-2 December 2011, pp. 25-25
Eduard DOLUSIC, Sara MODAFFARI, Johan WOUTERS, Bernard MASEREEL, Raphael FRÉDÉRICK
2011
Indole-pyridinyl-ethanones as novel inhibitors of indoleamine-2,3- dioxygenase (IDO), a promising target for anti-cancer immunotherapy, in Book of Abstracts, 47èmes RICT, 6-8 juillet 2011, Lyon, France, volume IS08, pp. 136-136
Eduard DOLUSIC, Pierre LARRIEU, Sébastien BLANC, Laurence MOINEAUX, Frédéric SAPUNARIC, Jenny POUYEZ, Delphine COLETTE, Graeme FRASER, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Jean-Marie FRÈRE, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2011
SYNTHESIS, ACTIVITY, CRYSTAL AND ELECTRONIC PROPERTIES OF ISOMERS OF CHLORO-PYRIDINYLVINYL-1H-INDOLES, in Book of Abstracts, 25èmes Journées Franco-belges de Pharmacochimie, 19-20/05/11, Liège, volume P20, pp. 45-45
Laurence MOINEAUX, Sophie LAURENT, Eduard DOLUSIC, Jérémy RENIERS, Bernadette NORBERG, Jean-Marie FRÈRE, Moreno GALLENI, Benoît VAN DEN EYNDE, Bernard MASEREEL, Raphael FRÉDÉRICK, Johan WOUTERS
2011
Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy., in Book of Abstracts, Emerging Targets and Treatments: Opportunities and Challenges for Drug Design, Ghent, 25 November 2011, volume P22
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Paulette CHARLIER, Sophie LAURENT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2011
Novel Inhibitors of Indoleamine 2,3-Dioxygenase (IDO), a Target for Anti-Cancer Immunotherapy, in Book of Abstracts, XVIIIème Journée Jeunes Chercheurs, 04/02/11, Paris, France
Eduard DOLUSIC, Sébastien BLANC, Pierre LARRIEU, Laurence MOINEAUX, Delphine COLETTE, Graeme FRASER, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Johan WOUTERS, Bernard MASEREEL, Benoît VAN DEN EYNDE, Raphael FRÉDÉRICK
2011
AROMATIC THIOSEMICARBAZONES ARE INHIBITORS OF TRYPTOPHAN 2,3-DIOXYGENASE (TDO), AN EMERGING TARGET FOR CANCER TREATMENT, in Book of Abstracts, 4th International Symposium on Advances in Synthetic and Medicinal Chemistry (ASMC 11), St. Petersburg, Russia, August 21-25, 2011, volume P157, pp. 270-270
Eduard DOLUSIC, Sara MODAFFARI, Pierre LARRIEU, Christelle VANCRAEYNEST, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Johan WOUTERS, Bernard MASEREEL, Benoît VAN DEN EYNDE, Raphael FRÉDÉRICK
2010
Synthesis, crystal and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles, in Abstracts, The sixth Belgian Crystallography Symposium (BCS-6), 13 October 2010, Brussels, Belgium
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2010
Indole-pyridinyl-ethanones as Novel Inhibitors of Indoleamine 2,3-Dioxygenase (IDO), a Promising Target for Anti-Cancer Immunotherapy, in Book of Abstracts, XXIVth European Colloquium on Heterocyclic Chemistry, Vienna, Austria, August 23-27, 2010, pp. PO-41
Eduard DOLUSIC, Sébastien BLANC, Pierre LARRIEU, Laurence MOINEAUX, Delphine COLETTE, Graeme FRASER, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Johan WOUTERS, Bernard MASEREEL, Benoît VAN DEN EYNDE, Raphael FRÉDÉRICK
2010
Design, synthesis and study of inhibitors of tryptophan 2,3-dioxygenase (TDO), a promising target for cancer therapy, in Abstracts, école doctorale Structure et Fonction des Macromolécules Biologiques, Bioinformatique et Modélisation (SFMBBM), Liège, Belgium, 10 December 2010
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Raphael FRÉDÉRICK
2010
Conception, synthèse et étude d'inhibiteurs de la tryptophane 2,3-dioxygénase (TDO), une cible prometteuse pour le traitement du cancer, in Abstracts, Séminaire des jeunes chercheurs Télévie 2011, Brussels, Belgium, 7 December 2010
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2010
Tryptophan 2,3-dioxygenase (TDO) inhibitors : Identification of new scaffolds using virtual screening, in Abstracts, Journée scientifique de la Société royale de chimie (SRC), Gembloux, Belgium, 14 October 2010
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2009
Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs ? , in Abstract book - Annual Meeting of Belgian Society on Thrombosis and Haemostasis
Severine ROBERT, Jérémie GHIOTTO, Bernard PIROTTE, Jean-Louis DAVID, Bernard MASEREEL, Lionel POCHET, Jean-Michel DOGNÉ
2008
Design, synthesis and pharmacological evaluation of novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors., in Abstract book - Small Molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry
Severine ROBERT, Carine BERTOLLA, Bernard MASEREEL, Jean-Michel DOGNÉ, Lionel POCHET
2008
Risk assessment of nanoparticles on human health using in vitro models : a preliminary study, in 4th international congress of nanotechnology & clean tech 2007
Jean-Pascal PIRET, Sebastien VANKONINGSLOO, Renaud VIGNERON, Stéphanie ROLIN, Christelle SAOUT, Bernard MASEREEL, Joseph DELHALLE, Stephane LUCAS, Olivier TOUSSAINT
2008
Nanotoxico: Toxicological assessment of engineered nanoparticles using in vitro and in vivo models.
Stéphanie ROLIN, Bernard MASEREEL, Sebastien VANKONINGSLOO, Jean-Pascal PIRET, Stephane LUCAS, Olivier TOUSSAINT
2008
A potential new drug delivery system for cancer therapy: biotin-labelled beta-cyclodextrin. , in Abstract book - Small Molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry
Carine BERTOLLA, Severine ROBERT, Lionel POCHET, Bernard MASEREEL
2008
Application of the boron neutron capture therapy to the carbonic anhydrase IX, in Abstract book - XIII International Conference on Boron Chemistry, pp. P014
Julien DEGLIM, Anne THIRY, Johan WOUTERS, Bernard MASEREEL
2007
Microwave assisted medicinal chemistry: application to the synthesis of coumarins and cyclodextrins, in Abstract Book-New Drugs and Drug Candidates: Recent Achievements in Medicinal Chemistry
Carine BERTOLLA, Severine ROBERT, Lionel POCHET, Bernard MASEREEL
2007
Application of the boron neutron capture therapy to the carbonic anhydrases, in Abstract Book-13th Belgian Forum of Pharmaceutical Sciences
Julien DEGLIM, Anne THIRY, Johan WOUTERS, Bernard MASEREEL
2007
Beta-cyclodextrin coupled to oxytocine: synthesis and pharmacological evaluation of a new potential drug carrier system, in Abstract Book-13th Belgian Forum of Pharmaceutical Sciences
Carine BERTOLLA, Stéphanie ROLIN, Lionel POCHET, Bernard MASEREEL
2007
Nouveaux senseurs chimiques à base de beta-cyclodextrines comportant un motif coumarine. Synthèse, détermination structurale et étude des variations spectroscopiques, in Abstract Book-21ème Journées Franco-Belges de Pharmacochimie
Carine BERTOLLA, Lionel POCHET, Bernard MASEREEL
2007
Towards new leads for selective carbonic anhydrase IX inhibition: synthesis, pharmacological evaluation and combined ligand-based and target-based approach, in Abstract Book-New Drugs and Drug Candidates : Recent Achievements in Medicinal Chemistry
Anne THIRY, Marie LEDECQ, Jean-Michel DOGNÉ, Claudiu T. SUPURAB, Johan WOUTERS, Bernard MASEREEL
2007
Carbonic anhydrase inhibitors: synthesis, biological evaluation and rational drug design to target the tumor-associated CA IX, in Abstract Book-13th Belgian Forum of Pharmaceutical Sciences
Anne THIRY, Marie LEDECQ, Jean-Michel DOGNÉ, claudiu T. SUPURAN, Johan WOUTERS, Bernard MASEREEL
2007
Inhibiteurs d'anhydrases carboniques. Evaluation de l'effet anticonvulsivant d'indanesulfonamides, in Abstract Book-21èmes Journées Franco-Belges de Pharmacochimie
Anne THIRY, Aurélie FRANKART, Catherine MICHAUX, Jean-Michel DOGNÉ, Claudiu T. SUPURAN, Johan WOUTERS, Bernard MASEREEL
2007
Nouvelles coumarines 3-carboxamides en tant qu'inhibiteurs de facteur XIIa, in Abstract Book-21èmes Journées Franco-Belges de Pharmacochimie
Severine ROBERT, Carine BERTOLLA, Bernard MASEREEL, Jean-Michel DOGNÉ, Lionel POCHET
2007
Le profil d'activité de thrombine: un puissant test de criblage ex vivo pour le développement d'agents anticoagulants, in Abstract Book-21èmes Journées Franco-Belges de Pharmacochimie
Severine ROBERT, Jérémie GHIOTTO, Bernard PIROTTE, Jean-Louis DAVID, Bernard MASEREEL, Lionel POCHET, Jean-Michel DOGNÉ
2007
Thrombin activity profile: a powerful ex vivo screening test for the development of anticoagulant drugs, in Abstract Book-XXIst Congress of the International Society on Thrombosis and Haemostasis
Severine ROBERT, Jérémie GHIOTTO, Bernard PIROTTE, Jean-Louis DAVID, Bernard MASEREEL, Lionel POCHET, Jean-Michel DOGNÉ
2007
Pharmacological evaluation of 6-chloromethyl-coumarins bearing a basic moiety in the 3-position as new anticoagulant drugs, in Abstract Book-New Drugs and Drug Candidates: Recent Achievements in Medicinal Chemistry
Severine ROBERT, Raphael FRÉDÉRICK, Bernard MASEREEL, Jean-Michel DOGNÉ, Lionel POCHET
2007
Thrombin activity profile: a rapid, reliable and relevant ex vivo screening test for the development of anticoagulant drugs, in Abstract Book-13th Belgian Forum of Pharmaceutical Sciences
Severine ROBERT, Jérémie GHIOTTO, Bernard PIROTTE, Jean-Louis DAVID, Bernard MASEREEL, Lionel POCHET, Jean-Michel DOGNÉ
2006
Évaluation pharmacologique de la beta-cyclodextrin couplée à l'ocytocine en tant que nouveau véhicule moléculaire, in Abstract Book - XXèmes Journées Franco-Belges de Pharmacochimie
Carine BERTOLLA, Stéphanie ROLIN, Lionel POCHET, Bernard MASEREEL
2006
Développement d'inhibiteurs sélectifs de thrombine : optimisation du substituant en position P1, in Abstract Book-20èmes Journées Franco-Belges de Pharmacochimie
Severine ROBERT, Raphael FRÉDÉRICK, Bernard MASEREEL, Lionel POCHET
2005
Évaluation biologique de coumarines en tant qu'inhibiteurs du complexe facteur tissulaire/facteur VIIa, in Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie
Severine ROBERT, Raphael FRÉDÉRICK, Bernard MASEREEL, Lionel POCHET
2005
Structure-based design of coumarins as potent thrombin inhibitors, in Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie
Raphael FRÉDÉRICK, Severine ROBERT, Caroline CHARLIER, Jerome DE RUYCK, Bernard MASEREEL, Lionel POCHET
2005
Purification de beta-cyclodextrines monofonctionnalisées par chromatographie échangeuse ionique : étude comparative , in Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie
Carine BERTOLLA, Anne-Marie MURRAY, Lionel POCHET, Bernard MASEREEL
2005
Developpement d'indanesulfonamides inhibiteurs de l'anhydrase carbonique IX, in Abstract Book-19èmes Journées Franco-Belge de pharmacochimie
Anne THIRY, Marie LEDECQ, Celine CHAZALETTE, Johan WOUTERS, Claudiu T. SUPURAN, Bernard MASEREEL
2004
Coumarins as inhibitors of serine proteases of the coagulation cascade, in Abstract Book-XVIIIth International Symposium on Medicinal Chemistry
Raphael FRÉDÉRICK, Severine ROBERT, Caroline CHARLIER, Bernard MASEREEL, Lionel POCHET
2004
Evaluation pharmacologique chez le cobaye d'une sulfonylurée originale (BM-520) apparentée au torasémide en tant qu'antagoniste du récepteur du TXA2. , in Abstract book - XVIIIèmes journées franco-belges de pharmacochimie
Caroline VASTERSAEGHER, Jean-Michel DOGNÉ, Julien HANSON, Bernard MASEREEL, Stéphanie ROLIN
2004
Coumarins as serine protease inhibitors, in Abstract Book-XVIIIth International Symposium on Medicinal Chemistry
Lionel POCHET, Raphael FRÉDÉRICK, Severine ROBERT, Stéphanie ROLIN, Bernard MASEREEL
2004
Nouveaux dérivés cyanoguanidines de beta-cyclodextrines, in Abstract Book-18ème Journées Franco-Belges de Pharmacochimie
Carine BERTOLLA, Lionel POCHET, Bernard MASEREEL
2004
Évaluation biologique de dérivés coumariniques en tant qu'inhibiteurs de protéases à sérine de la cascade de la coagulation, in Abstract Book-18èmes Journées Franco-Belges de Pharmacochimie
Severine ROBERT, Raphael FRÉDÉRICK, Bernard MASEREEL, Lionel POCHET
2004
Synthesis of new cyanoguanidine beta-cyclodextrin derivatives, in Abstract Book-12th International Cyclodextrin Symposium
Carine BERTOLLA, Lionel POCHET, Bernard MASEREEL
2004
Étude du mode d'interaction de coumarines avec la thrombine, in Abstract Book-18èmes Journées Franco-Belges de Pharmacochimie
Raphael FRÉDÉRICK, Caroline CHARLIER, Jerome DE RUYCK, Marc DIEU, Severine ROBERT, Bernard MASEREEL, Lionel POCHET
2004
Conception, synthèse et évaluation pharmacologique d'une sulfonylurée nitrobenzénique originale modulatrice de la voie du TXA2 en tant qu'agent anti-asthmatique potentiel., in Abstract book - XVIIIèmes Journées franco-belges de pharmacochimie
Stéphanie ROLIN, Michel PÉTEIN, Jean-Michel DOGNÉ, Catherine MICHAUX, Caroline VASTERSHAEGER, Bernard MASEREEL
2003
Synthèse de beta-cyclodextrines modifiées, in Abstract Book-17èmes Journées Franco-Belges de Pharmacochimie
Carine BERTOLLA, Marie PIETTE, Brigitte EVRARD, Luc DELATTRE, Géraldine PIEL, Raphael FRÉDÉRICK, Bernard MASEREEL
2003
Effect of BM-573, a dual TXA2 synthase inhibitor and TXA2 receptor antagonist on infarct size in a porcine model of coronary thrombosis induced by ferric chloride., in Abstract book - Meeting de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques
Stéphanie ROLIN, Jean-Michel DOGNÉ, Michel PÉTEIN, Jacques DELARGE, Bernard MASEREEL
2001
Antiplatelet and antithrombotic properties of BM-573, a novel combined thromboxane receptor antagonist and thromboxane synthase inhibitor, in Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie, pp. 70
Jean-Michel DOGNÉ, Patricia BENOIT, Xavier DE LEVAL, Philippe NEVEN, Stéphanie ROLIN, Catherine MICHAUX, Jean-Louis DAVID, Jacques DELARGE, Bernard MASEREEL
2001
Biological evaluation of a novel sulfonylurea, BM-567, with a dual activity on thromboxane A2 synthase and receptor, in Abstract book - 10ème Forum de la Société Belge des Sciences Pharmaceutiques
Stéphanie ROLIN, Jean-Michel DOGNÉ, Xavier DE LEVAL, Jacques DELARGE, Bernard MASEREEL
2001
Comparaison de l'effet de deux dérivés de l'acide 6-(acétoxyméthyl)-2-oxo-2H-1-benzopyrane-3-carboxylique sur l'inhibition de l'invasion cellulaire in vitro et in vivo, in Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie, pp. 73
Isabelle KEMPEN, Serge POCHET, D PAPAPOSTOLOU, Stéphane COUNEROTTE, Bernard MASEREEL, Jean-Michel FOIDART, Michèle REBOUD-RAVAUX, Francis FRANKENNE, Bernard PIROTTE
2001
Effects of thromboxane A2 receptor antagonists and COX inhibitors on osteogenic sarcoma cell-induced platelet aggregation, in Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie., pp. 69
Xavier DE LEVAL, Jacques DELARGE, Philippe NEVEN, Catherine MICHAUX, Bernard MASEREEL, Bernard PIROTTE, Jean-Louis DAVID, Jean-Michel DOGNÉ
2001
Dérivés pyridiniques et benzéniques de l'amiloride : synthèse et évaluation pharmacologique exploratoire en tant qu'inhibiteurs de l'échange sodium-proton, in Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie, pp. 74
Didier LAECKMANN, Françoise ROGISTER, Jacques DELARGE, Bernard MASEREEL
2001
Préparation et évaluation pharmacologique d'analogues benzéniques de l'amiloride substitués sur l'azote distal de la foncxtion acylguanidine en tant qu'inhibiteurs de l'échange sodium-calcium, in Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie, pp. 75
Didier LAECKMANN, Françoise ROGISTER, Jacques DELARGE, Bernard MASEREEL
2001
Pharmacological effect of BM-593, a novel sulfonylurea acting as thromboxane A2 receptor antagonist and thromboxane synthase inhibitor on human platelets and isolated smooth muscles, in Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie, pp. 78
Stéphanie ROLIN, Jean-Michel DOGNÉ, Jacques DELARGE, Bernard MASEREEL
2001
In vitro biological evaluation of two cyclooxygenase-2 inhibitors, in Abstract book - XIVèmes Journées franco-belges de pharmacochimie
Stéphanie ROLIN, Carine MICHIELS, Bernard MASEREEL, Xavier DE LEVAL, François DURANT, Catherine MICHAUX
2001
Pharmacological effects of BM-593, a novel sulfonylurea acting as thromboxane A2 receptor antagonist and thromboxane synthase inhibitor on human platelets and isolated smooth muscles., in Abstract book - XVèmes Journées franco-belges de pharmacochimie
Stéphanie ROLIN, Bernard MASEREEL, Jacques DELARGE, Jean-Michel DOGNÉ
2001
Synthèse et évaluation enzymatique de nouvelles coumarines en tant qu'inhibiteurs de thrombine, in Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie, pp. 60
Lionel POCHET, Caroline DOUCET, Bernard PIROTTE, Raphael FRÉDÉRICK, Jacques DELARGE, Michèle REBOUD-RAVAUX, Bernard MASEREEL
2001
Towards new leads for selective cyclooxygenase-2 (COX-2) inhibition, in Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie, pp. 84
Catherine MICHAUX, Stéphanie ROLIN, Xavier DE LEVAL, Bernard MASEREEL, François DURANT, Johan WOUTERS
2001
Synthèse et évaluation pharmacologique d'un méthanesulfonamide pyridinique apparenté à l'acide niflumique, in Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie, pp. 49
Fabien JULÉMONT, Xavier DE LEVAL, Philippe NEVEN, Philippe DEVEL, Bernard PIROTTE, Jacques DELARGE, Bernard MASEREEL, Catherine MICHAUX, Jean-Michel DOGNÉ
2001
Pharmacological profile of BM-567, a novel thromboxane A2 receptor antagonist and thromboxane A2 receptor antagonist and thromboxane A2 synthase inhibitor on the human platelets and isolated smooth muscles, in Abstract book - Meeting de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques
Stéphanie ROLIN, Jean-Michel DOGNÉ, Jacques DELARGE, Bernard MASEREEL
2000
BM-531, a novel sulfonylurea acting as thromboxane A2 receptor antagonist and thromboxane synthase inhibitor, in Abstract book - XIVèmes Journées franco-belges de pharmacochimie
Stéphanie ROLIN, Jean-Michel DOGNÉ, Jacques DELARGE, Bernard MASEREEL
2000
BM-573, a novel potent dual acting agent for thromboxane A2 receptor antagonism and thromboxane A2 synthase inhibition, in Abstract book-9ème Forum de la Société Belge des Sciences Pharmaceutiques
Stéphanie ROLIN, Jean-Michel DOGNÉ, Jacques DELARGE, Bernard MASEREEL
1999
Evaluation d'une nouvelle sulfonylcyanoguanidine en tant qu'antagoniste du thromboxane A2., in Abstract book - XIIIèmes Journées franco-belges de pharmacochimie
Stéphanie ROLIN, Jean-Michel DOGNÉ, Philippe NEVEN, Xavier DE LEVAL, Jacques DELARGE, Bernard MASEREEL

Comptes rendus scientifiques

2010
The calibrated thrombin generation test (cTGT) : a gold standard assay to assess the procoagulant activity of nanomaterials, in 50) NARILIS symposium. Faculté de Médecine. FUNDP Namur. October 23th, 2010
Julie LALOY, Severine ROBERT, Catherine MARBEHANT, François MULLIER, Jorge Humberto MEJIA MENDOZA, Jean-Pascal PIRET, Joseph DELHALLE, Stephane LUCAS, Bernard CHATELAIN, Jean-Michel DOGNÉ, Olivier TOUSSAINT, Bernard MASEREEL, Stéphanie ROLIN
2010
Discovery and Optimization Of Indole-pyridinyl-ethanones as Novel Inhibitors of Indoleamine-2,3-Dioxygenase (IDO), a Promising Target for Anti-Cancer Immunotherapy, in Drugs of the Future, volume 35, issue suppl. A, pp. 181-182
Raphael FRÉDÉRICK, Sébastien BLANC, Pierre LARRIEU, Laurence MOINEAUX, Delphine COLETTE, Graeme FRASER, Vincent STROOBANT, Luc PILOTTE, Didier COLAU, Johan WOUTERS, Bernard MASEREEL, Benoît VAN DEN EYNDE, Eduard DOLUSIC
2010
STRUCTURAL AND ENZYMATIC STUDY OF TRYPTOPHAN 2,3- DIOXYGENASE (TDO), A POTENTIAL TARGET IN ANTICANCER IMMUNOTHERAPY, in Drugs of the Future, volume 35, issue suppl. A, pp. 217-218
Laurence MOINEAUX, Caroline CHARLIER, Eduard DOLUSIC, Pierre LARRIEU, Luc PILOTTE, Didier COLAU, Vincent STROOBANT, Moreno GALLENI, Bernard MASEREEL, Benoît VAN DEN EYNDE, Johan WOUTERS, Raphael FRÉDÉRICK
2009
Potential nanotoxicity in blood : Effects of engineered nanoparticles on human blood constituents, in Nanofac 2009
Julie LALOY, Catherine MARBEHANT, Severine ROBERT, François MULLIER, Bernard CHATELAIN, Jean-Michel DOGNÉ, Olivier TOUSSAINT, Bernard MASEREEL, Stéphanie ROLIN
2008
Structural insights into the inhibition mode of the activated coagulation factor XII by coumarins, in Drugs of the Future, volume 33, issue suppl A, pp. 267
Catherine MICHAUX, Severine ROBERT, Marie DEL TEDESCO, Bernard MASEREEL, Jean-Michel DOGNÉ, Lionel POCHET
2008
Biotin tagged beta-cyclodextrin: a potential new drug targeting system for tumor therapy, in Drugs of the Future, volume 33, issue suppl. A, pp. 259
Carine BERTOLLA, Lionel POCHET, Bernard MASEREEL
2008
Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors, in Drugs of the Future, volume 33, issue suppl A, pp. 266
Severine ROBERT, Carine BERTOLLA, Bernard MASEREEL, Jean-Michel DOGNÉ, Lionel POCHET
2008
Microwave assisted medicinal chemistry : application to the synthesis of coumarins and cyclodextrins, in Chimie Nouvelle, volume 98, pp. 25-25
Carine BERTOLLA, Severine ROBERT, Lionel POCHET, Bernard MASEREEL
2008
Towards new leads for selective carbonic anhydrase IX inhibition: synthesis, pharmacologcal evaluation and combined ligand-based and target-based approach., in Chimie Nouvelle, volume 98, pp. 26-26
Anne THIRY, Marie LEDECQ, Jean-Michel DOGNÉ, Claudiu SUPURAN, Johan WOUTERS, Bernard MASEREEL
2008
Pharmacological evaluation of 6-chloromethyl-coumarins bearing a basic moeity in the 3-position as new anticoagulants drugs, in Chimie Nouvelle, volume 98, pp. 26-26
Severine ROBERT, Raphael FRÉDÉRICK, Bernard MASEREEL, Jean-Michel DOGNÉ, Lionel POCHET
2007
Thrombin activity profile: a powerful ex vivo screening test for the development of anticoagulant drugs, in Journal of Thrombosis and Haemostasis, volume 5, issue Suppl. 2, pp. PW-073
Severine ROBERT, Jérémie GHIOTTO, Bernard PIROTTE, Jean-Louis DAVID, Bernard MASEREEL, Lionel POCHET, Jean-Michel DOGNÉ
2006
Indanesulfonamides as carbonic anhydrase inhibitors, in Drugs of the Future, volume 31, issue A, pp. 84
Anne THIRY, Marie LEDECQ, Alessandro CECCHI, Jean-Michel DOGNÉ, Johan WOUTERS, Claudiu T. SUPURAN, Bernard MASEREEL
2006
Design, synthesis and biological evaluation of indanesulfonamides as carbonic anhydrase IX inhibitors, in Fundamental and Clinical Pharmacology, volume 20, pp. 626
Anne THIRY, Marie LEDECQ, Alessandro CECCHI, Jean-Michel DOGNÉ, Johan WOUTERS, Claudiu T. SUPURAN, Bernard MASEREEL
2004
Coumarins as serine protease inhibitors, in Drugs of the future, volume 29, issue A, pp. 171
Lionel POCHET, Raphael FRÉDÉRICK, Severine ROBERT, Stéphanie ROLIN, Bernard MASEREEL
2004
Synthesis of new cyanoguanidine beta-cyclodextrin derivatives, in Proceedings of the 12th International cyclodextrins symposium , pp. 159-162
Carine BERTOLLA, Lionel POCHET, Bernard MASEREEL
2004
Coumarins as inhibitors of serine proteases of the coagulation cascade, in Drugs of the future, volume 29 , issue A, pp. 172
Raphael FRÉDÉRICK, Severine ROBERT, Caroline CHARLIER, Bernard MASEREEL, Lionel POCHET
2004
Insight into the mode of action of coumarins as thrombin inhibitors, in Fundamental and Clinical Pharmacology, volume 18, pp. 595
Raphael FRÉDÉRICK, Caroline CHARLIER, Jerome DE RUYCK, Marc DIEU, Severine ROBERT, Bernard MASEREEL, Lionel POCHET
2003
A dual thromboxane inhibitor and thromboxane receptor antagonist prevents pig myocardial infarction induced by coronary thrombosis, in European Heart Journal, volume 24, pp. 325
Stéphanie ROLIN, Michel PÉTEIN, Vincent TCHANA-SATO, Jean-Michel DOGNÉ, Bernard LAMBERMONT, Alexandre GHUYSEN, Philippe KOLH, Bernard MASEREEL
2003
A dual thromboxane inhibitor and thromboxane receptor antagonist prevents pig myocardial infarction induced by coronary thrombosis, in Basic Research in Cardiology, volume 98, pp. 189
Stéphanie ROLIN, Michel PÉTEIN, Vincent TCHANA-SATO, Jean-Michel DOGNÉ, Bernard LAMBERMONT, Alexandre GHUYSEN, Philippe KOLH, Bernard MASEREEL
2003
Effect of BM-573, a dual TXA2 synthase inhibitor and TXA2 receptor antagonist on infarct size in a porcine model of coronary thrombosis by ferric chloride, in Pfllüg. Arch. - European Journal of Physiology, volume 446, pp. R4
Stéphanie ROLIN, Michel PETEIN, Jean-Michel DOGNÉ, Vincent TCHANA-SATO, Philippe KOLH, Bernard MASEREEL
2002
Design and pharmacological evaluation of a novel combined thromboxane A2 receptor antagonist and thromboxane synthase inhibitor derived from torasemide as promising antiplatelet agent, in Blood, volume 96, issue 11, pp. 230
Jean-Michel DOGNÉ, Xavier DE LEVAL , Stéphanie ROLIN, Philippe NEVEN, Philippe KOLH, Jean-Louis DAVID, G FILLET, Jacques DELARGE, Bernard MASEREEL
2002
Anti-platelet and antithrombotic properties of the nitrobenzenic sulfonylurea BM-573, in Fundamental and Clinical Pharmacology, volume 16, pp. 245
Jean-Michel DOGNÉ, Patricia BENOIT, Xavier DE LEVAL, Stéphanie ROLIN, Philippe NEVEN, Philippe KOLH, Bernard MASEREEL, Jean-Louis DAVID
2002
Antithrombotic properties of BM-573 an original dual thromboxane receptor antagonist and thromboxane synthase inhibitor, in Pathophysiology of Haemostasis and Thrombosis, volume 32, issue (S2), pp. 60
Jean-Michel DOGNÉ, Patricia BENOIT, Xavier DE LEVAL, Stéphanie ROLIN, Philippe KOLH, Alexandre GHYSEN, Vincent TCHANA-SATO, Bernard MASEREEL
2001
Pharmacological profile of BM-567, a novel thromboxane A2 receptor antagonist and thromboxane A2 synthase inhibitor on the human platelets and isolated smooth muscle, in Fundamental and Clinical Pharmacology, volume 15, pp. 363
Stéphanie ROLIN, Jean-Michel DOGNÉ, Jacques DELARGE, Bernard MASEREEL
2001
Pharmacological evaluation of BM-573 an original dual thromboxane receptor antagonist and thromboxane synthase inhibitor as novel potent antithrombotic agent, in Blood, volume december, issue suppl
Jean-Michel DOGNÉ, Xavier DE LEVAL, Patricia BENOIT, Philippe NEVEN, Laurence DE LEVAL, Stéphanie ROLIN, Jean-Louis DAVID, Bernard MASEREEL
2001
Design and pharmacological evaluation of an original non-carboxylic thromboxane receptor antagonist and thromboxane synthase inhibitor as promising antiplatelet agent, in Thrombosis and Haemostasis, issue July suppl, pp. P1630
Jean-Michel DOGNÉ, Xavier DE LEVAL, Stéphanie ROLIN, Philippe NEVEN, Philippe KOLH, Jean-Louis DAVID, Jacques DELARGE, Bernard MASEREEL
2001
Pharmacological evaluation of original sulfonylureas as thromboxane A2 antagonists, in Fundamental and Clinical Pharmacology, volume 300, pp. 14
Jean-Michel DOGNÉ, Xavier DE LEVAL, Philippe NEVEN, Fabian SOMERS, Jacques DELARGE, Stéphanie ROLIN, Catherine MICHAUX, Johan WOUTERS, Bernard PIROTTE, Jacques DAMAS, Bernard MASEREEL
2000
Design and pharmacological evaluation of a novel combined thromboxane A2 receptor antagonist and thromboxane synthase inhibitor derived from torasemide as promising antiplatelet agent, in Blood, volume 96, issue 11, pp. 230
Jean-Michel DOGNÉ, Xavier DE LEVAL, Stéphanie ROLIN, Philippe NEVEN, Philippe KOLH, Jean-Louis DAVID, Georges FILLET, Jacques DELARGE, Bernard MASEREEL
2000
Inhibition of cellular invasion by 3-chlorophenyl 6-(acétoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylate., in European Journal of Physiology, volume 440, issue 78, pp. R252
Isabelle KEMPEN, Lionel POCHET, D PAPAPOSTOLU, N BOGGETTO, Caroline DOUCET, Bernard MASEREEL, Jean-Michel FOIDART, Michèle REBOUD-RAVAUX, Francis FRANKENNE, Bernard PIROTTE
2000
Evaluation of classical NSAIDs on COX-1 and COX-2 purified enzymes and prognosis of their effects on physiological responses, in Fundamental and Clinical Pharmacology, volume 14, pp. 167
Xavier DE LEVAL, Yves HENROTIN, Bernard MASEREEL, Fabian SOMERS, Philippe NEVEN, Philippe DEVEL, Jacques DELARGE, Jean-Michel DOGNÉ
2000
Design, synthesis and pharmacological evalution of original thromboxane receptor antagonists., in Mediators of Inflammation, volume 9, pp. 53
Jean-Michel DOGNÉ, Xavier DE LEVAL, Jacques DELARGE, Jean-Yves REGINSTER, Yves HENROTTIN, Philippe NEVEN, Stéphanie ROLIN, Bernard MASEREEL
2000
Effects of TXA2 receptor antagonists derived from torasemide on platelet function, in Fundamental and Clinical Pharmacology, volume 14, pp. 168
Jean-Michel DOGNÉ, Xavier DE LEVAL, Philippe NEVEN, Stéphanie ROLIN, Fabian SOMERS, Jean-Louis DAVID, Jacques DELARGE, Bernard MASEREEL
2000
Pharmacological evaluation of original sulfonylureas as thromboxane A2 antagonists, in Fundamental and clinical Pharmacology, volume 14, pp. 300
Jean-Michel DOGNÉ, Xavier DE LEVAL, Philippe NEVEN, Fabian SOMERS, Jacques DELARGE, Stéphanie ROLIN, Catherine MICHAUX, Johan WOUTERS, Bernard PIROTTE, Jacques DAMAS, Bernard MASEREEL
2000
Characterization of the antiplatelet activity of ticlopidine and acetylsalicylic acid by PFA-100, in Fundamental and Clinical Pharmacology, volume 14, pp. 168
Jean-Michel DOGNÉ, Xavier DE LEVAL, Philipp NEVEN, Stéphanie ROLIN, Jean-Louis DAVID, Jacques DELARGE, Bernard MASEREEL
2000
Profile of nimesulide and nimesulide beta-cyclodextrin on chondrocyte metabolism., in Fundamental and Clinical Pharmacology, volume 14, pp. 169
Xavier DE LEVAL, Jean-Michel DOGNÉ, Bernard MASEREEL, Jean-Yves REGINSTER, Philippe NEVEN, A LABASSE, Jacques DELARGE, Yves HENROTIN
2000
BM-144, a novel thromboxane A2 receptor antagonist relaxes trachea guinea pig in vitro, in Journal of Allergy and Clinical Immunology, volume 105, pp. S21-S21
Jean-Michel DOGNÉ, Xavier DE LEVAL, Philippe NEVEN, Stéphanie ROLIN, Jacques DELARGE, Bernard MASEREEL
2000
Inhibition of cellular invasion by 3-chlorophenyl 6-(acétoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylate, in European Journal of Physiology, volume 440, issue 78, pp. R252
Isabelle KEMPEN, Lionel POCHET, D PAPAPOSTOLU, Nicole BOGETTO, Caroline DOUCET, Bernard MASEREEL, Jean-Michel FOIDART, Michèle REBOUD-RAVAUX, Francis FRANKENNE, Bernard PIROTTE
1999
Antiplatelet properties of BM-519, a novel combined thromboxane A2 receptor antagonist and thromboxane synthase inhibitor, in Blood, volume 94, issue (suppl 1), pp. 3625
Jean-Michel DOGNÉ, Xavier DE LEVAL, Jacques DELARGE, Philippe NEVEN, Stéphanie ROLIN, Jean-Louis DAVID, Georges FILLET, Bernard MASEREEL
1999
BM-519, a novel non-carboxylic thromboxane A2 antagonist, in Fundamental and Clinical Pharmacology, volume 13, issue (suppl 1), pp. 191s
Bernard MASEREEL, Fabrice LACAN, Jeanine FONTAINE, Alain NUHRICH, Jacques DELARGE, Lionel POCHET, Jean-Michel DOGNÉ
1999
In vivo and in vitro effect of new glibenclamides isosteres, in Fundamental and Clinical Pharmacology, volume 13, issue (suppl 1), pp. 381s
Philipp LEBRUN, Raogo OUEDRAOGO, QA NGUYEN, Marie-Hélène ANTOINE, Mark J DUNNE, Bernard PIROTTE, Bernard MASEREEL
1999
PFA-100, a novel pharmacological tool for characterization of antiplatelet potency of thromboxane receptor antagonists, in Blood, volume 94 (suppl 1), pp. 3626
Jean-Michel DOGNÉ, Xavier DE LEVAL, Jacques DELARGE, Philippe NEVEN, Stéphanie ROLIN, Jean-Louis DAVID, Georges FILLET, Bernard MASEREEL
1998
Insulinotropic effect of glibenclamide isosteres, in Fundamental and Clinical Pharmacology, volume 12, pp. 307
Q.A. NGUYEN, Lionel POCHET, Raogo OUEDRAOGO, Mark J. DUNNE, Bernard MASEREEL, Philippe LEBRUN, Marie-Hélène ANTOINE
1996
Synthesis, bioavailability and anticonvulsant activity of 2-cyanoguanidinophenytoin, a structural analogue of phenytoin, in Journal de Pharmacie de Belgique, volume 51, pp. 113
Didier LAMBERT, Bernard MASEREEL, Didier GALLEZ, Muriel GEURTS, Gerhard SCRIBA
1996
Design and synthesis of aromatic esters and amides of 6-chloromethyl-2-oxo-2H-benzopyran-3 carboxylic acid as inhibitors of alpha-chymotrypsin, in Journal de Pharmacie de Belgique, volume 51, pp. 117
Lionel POCHET, Caroline DOUCET, Marc SCHYNTS, N THIERRY, Nicole BOGGETTO, Bernard PIROTTE, Bernard MASEREEL, Pascal DE TULLIO, Jacques DELARGE, Michèle REBOUD-RAVAUX
1996
3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to both diazoxide and pinacidil: a new class of potassium channel openers, in Journal de Pharmacie de Belgique, volume 51, pp. 117
Bernard PIROTTE, Smaïl KHELILI, Pascal DE TULLIO, ZY FANG, Raogo OUEDRAOGO, Marie-Hélène ANTOINE, Jeanine FONTAINE, Bernard MASEREEL, Daniel DEWALQUE, Jacques DAMAS, Lionel POCHET, Jacques DELARGE, Philippe LEBRUN
1996
2-,3- and 4-substituted pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers, in Journal de Pharmacie de Belgique, volume 51, pp. 108
Pascal DE TULLIO, Bernard PIROTTE, Raogo OUEDRAOGO, Léon DUPONT, Philippe LEBRUN, ZY FANG, Bernard MASEREEL, Jeanine FONTAINE, Marie-Hélène ANTOINE, Philippe NEVEN, Lionel POCHET, Jacques DELARGE
1996
Les canaux potassiques ATP-dépendants et la secrétion d'insuline. Effets du BPDZ 62, in Journal de Pharmacie de Belgique, volume 51, issue 3b, pp. 41
Raogo OUEDRAOGO, Bernard PIROTTE, Marie-Hélène ANTOINE, Pascal DE TULLIO, Bernard MASEREEL, M DUNNE, C KANE, Philippe LEBRUN
1996
The selectivity of some pyridobenzazepine derivatives for the dopamine D4 receptor, in Journal de Pharmacie de Belgique, volume 51, issue 3b, pp. 16
Jean-François LIÉGEOIS, Jacques BRUHWYLER, Jacques DAMAS, Françoise ROGISTER, Bernard MASEREEL, Josef GECZY, Jacques DELARGE
1996
Synthèse de nouvelles pyridothiadiazines et leur évaluation en tant que modulateurs des récepteurs glutamatergiques à l'acide alpha-amino-3-hydroxy-5-méthyl-4-isoxazolepropionique, in Journal de Pharmacie de Belgique, volume 51, issue 3b, pp. 20
Ousman DIOUF, Bernard PIROTTE, Tchao PODONA, Pascal DE TULLIO, Bernard MASEREEL, Jacques DELARGE, P MORAIN, J LEPAGNOL
1996
Nouvelles stratégies de synthèse des pyridothiadiazinedioxydes structuralement apparentées au diazoxide, in Journal de Pharmacie de Belgique, volume 51, issue 3b, pp. 19
Smaïl KHELILI, Bernard PIROTTE, Pascal DE TULLIO, Bernard MASEREEL, Jacques DELARGE
1996
Nouveaux dérivés de l'acide 6-chloromé thyl-2-oxo-2H-1-benzopyran-3-carboxylique en tant qu' inhibiteurs de protéases à sérine: étude des relations structure-activité explicant leur sélectivité d'action, in Journal de Pharmacie de Belgique, volume 51, issue 3b, pp. 18
Caroline DOUCET, Lionel POCHET, Marc SCHYNTS, Bernard PIROTTE, N THIERRY, Nicole BOGGETTO, Bernard MASEREEL, Pascal DE TULLIO, Jacques DELARGE, Michèle REBOUD-RAVAUX
1996
Anticonvulsant properties of 4-cycloalkyamino-pyrid-3-yl sulfonylureas and -thioureas, in Journal de Pharmacie de Belgique, volume 51, issue 3b, pp. 17
Bernard MASEREEL, Didier LAMBERT, Fabienne BIA, Ousman DIOUF, Jean-François LIÉGEOIS, Pascal DE TULLIO, Bernard PIROTTE, Lionel POCHET, Smaïl KHELILI, Jacques DELARGE
1995
3-Arylcarboxamidomethyl-4H-pyrido [4,3-e]-1,2-4-thiadiazine 1,1-dioxydes en tant qu'antagonistes non-peptidiques de la cholécystokinine: synthèse et évaluation pharmacologique, in Journal de Pharmacie de Belgique, volume 50, pp. 253
Bernard PIROTTE, Pascal DE TULLIO, Tchao PODONA, Bernard MASEREEL, Daniel Henri CAIGNARD, Pierre RENARD, Jacques DELARGE
1995
Pyridothiadiazinedioxides and benzothiadiazinedioxides structurally related to diazoxide. New activators of the pancreatic and the vascular K-ATP channels, in European Journal of Physiology/Pflügers Archiv, volume 430, pp. R8
Bernard PIROTTE, Bernard MASEREEL, Jacques DELARGE
1995
Synthesis and pharmacology of N"-(4-arylaminopyrid-3-yl)sulfonyl-N-cyano-N'-isopropylguanidines, in Journal de Pharmacie de Belgique, volume 50, pp. 250
Bernard MASEREEL, Marc SCHYNTS, Bernard PIROTTE, Pascal DE TULLIO, Jacques DELARGE
1994
Synthesis of a series of 4H-1,2,4,-pyridothiadiazine 1,1-dioxydes and their evaluation as new potassium channel openers, in Journal de Pharmacie de Belgique, volume 49, pp. 85
Pascal DE TULLIO, Bernard PIROTTE, Léon DUPONT, Philippe LEBRUN, Marie-Hélène ANTOINE, Jeanine FONTAINE, Bernard MASEREEL, Marc SCHYNTS, Jacques DELARGE
1994
Pharmacology of a new sulphonylurea (BM 27) effective in brain edema, in Journal de Pharmacie de Belgique, volume 49, pp. 88
Bernard MASEREEL, Marc SCHYNTS, Bernard PIROTTE, Pascal DE TULLIO, Jacques DELARGE
1994
A novel coumarinic inhibitor inactivates cathepsin G but not human leukocyte elastase, in Journal de Pharmacie de Belgique, volume 49, pp. 258
S FESQUET, Marc SCHYNTS, Nicole BOGGETTO, Bernard MASEREEL, Bernard PIROTTE, Jacques DELARGE, KY JIANG, Michèle REBOUD
1994
Etude structurale comparative du pinacidil, du diazoxide et du cromakalim, ouvreurs de canaux potassiques appartenant à trois classes chimiques distinctes, in Journal de Pharmacie de Belgique, volume 49, pp. 282
Léon DUPONT, Bernard PIROTTE, Pascal DE TULLIO, Bernard MASEREEL, Marc SCHYNTS, Jacques DELARGE
1994
Synthèse de dérivés 3-aminoaralkyl-2aryl-4H-pyrido [4,3-e]-1,2,4-thiadiazine 1,1-dioxydes et leur évaluation en tant qu'antagonistes de la cholécystokinine, in Journal de Pharmacie de Belgique, volume 49, pp. 244
Pascal DE TULLIO, Bernard PIROTTE, Bernard MASEREEL, Ousman DIOUF, Daniel Henri CAIGNARD, Pierre RENARD, Jacques DELARGE
1993
Improved pancreatic K-ATP channel openers belonging to the pyridothiadiazine chemical class, in Journal de Pharmacie de Belgique, volume 48, pp. 143
Bernard PIROTTE, Pascal DE TULLIO, Philippe LEBRUN, Marie-Hélène ANTOINE, Bernard MASEREEL, Marc SCHYNTS, Jacques DELARGE
1993
Loop diuretics and the renal Na+ K+ 2Cl- cotransport: Interaction model, in Journal de Pharmacie de Belgique, volume 48, pp. 141
Bernard MASEREEL, Marc SCHYNTS, Bernard PIROTTE, Jacques DELARGE
1992
3-Oxo-2H,4H-pyrido [2,3-e] [1,2,4]-thiadiazine 1,1-dioxide, a sweetening agent of the sulfonamide family structurally related to saccharin and acesulfame, in Pharmaceutische Weekblad, volume 14, issue suppl, pp. I10
Bernard PIROTTE, Pascal DE TULLIO, Bernard MASEREEL, Marc PARMENTIER, Marc SCHYNTS, Jacques DELARGE
1992
New dihydrocoumarin derivatives as potential mechanism-based inactivators of serine proteinases, in Pharmaceutische Weekblad, volume 14, issue suppl, pp. I11
Marc SCHYNTS, Nicole BOGGETTO, Bernard MASEREEL, Bernard PIROTTE, S FESQUET, I VERGELY, Jacques DELARGE, Michèle REBOUD
1992
New relative K+-sparing high ceiling diuretics related to torasemide, in Journal de Pharmacie de Belgique, volume 47, pp. 447
Bernard MASEREEL, Marc SCHYNTS, Emanuel LOHRMANN, Bernard PIROTTE, Rainer GREGER, Jacques DELARGE
1991
Loop diuretics: SAR, molecular interactions and target topography, in Archieve der Pharmazie, volume 324, pp. 650
Bernard MASEREEL, Léon DUPONT, emmanuel LOHRMANN, Marc SCHYNTS, Bernard PIROTTE, Rainer GREGER, Jacques DELARGE
1991
4-Amino-4H-1,2,4-triazole and 5-aminothiazole derivatives structurally related to ß -lactam antibiotics as potential inhibitors of serine proteases, in Archieve der Pharmazie, volume 324, pp. 658
Nicole BOGGETTO, Anne C VILAIN, Bernard PIROTTE, Bernard MASEREEL, I VERGELY, Léon DUPONT, Jacques DELARGE, Michèle REBOUD
1991
Inhibiteurs potentiels de protéases à sérine apparentés aux antibiotiques ß-lactamiques, in Regard sur la Biochimie, volume 6, pp. 91
Bernard PIROTTE, Anne C VILAIN, I VERGELY, Nicole BOGGETTO, Bernard MASEREEL, Léon DUPONT, Jacques DELARGE, Michèle REBOUD
1990
Structure-activity of sulfonylurea compounds (SUC) on Na-Cl transport in isolated perfused rabbit cortical thick ascending limbs of Henle's loop, in European Journal of Physiology, volume 415, issue suppl 1, pp. R40
Emmanuel LOHRMANN, R NITSCHKE, E SCHLATTER, Bernard MASEREEL, Jacques DELARGE, HJ LANG, HC ENGLERT, Rainer GREGER
1990
New lipophilic torasemide derivatives inhibit astrocytic potassium uptake and rat brain slices water uptake, in Journal de Pharmacie de Belgique, volume 45, pp. 64
Bernard MASEREEL, Marc SCHYNTS, Jacques DELARGE
1990
Structure-activity relationship of new torasemide derivatives on Na-K-2Cl cotransporter in perfused rabbit thick ascending limb of Henle's loop, in Pharmaceutisch Weekblad, volume 12, pp. E7
Bernard MASEREEL, Bernard PIROTTE, Marc SCHYNTS, Jacques DELARGE, Emmanuel LOHRMANN, R NITSCHKE, E SCHLATTER, R GREGER
1990
New sulfonylurea derivatives as potential antihypertensive drugs, in Journal de Pharmacie de Belgique, volume 45, pp. 405
Bernard MASEREEL, Bernard PIROTTE, Marc SCHYNTS, P FERRARI, Léopold THUNUS, Jacques DELARGE
1989
New torasemide derivatives inhibit brain slices and astrocytes swelling induced by potassium, in Journal of Neurochemistry, volume 52, pp. S183
Bernard MASEREEL, Thierry GRISAR, Jacques DELARGE, Marilyne BURETTE

Thèses

1993
Conception, synthèse et évaluation pharmacologique d'inhibiteurs du cotransport Na+ K+ 2Cl- astrocytaire. Le BM 27 un nouvel anti-oedémateux cérébral.
Bernard MASEREEL

Syllabus

2007
Notes de Cours d'Introduction aux Sciences Pharmaceutiques
Bernard MASEREEL
2007
Note de cours d'Analyse Pharmaceutique
Bernard MASEREEL, Lionel POCHET
2007
Notes de Cours de Biochimie
Bernard MASEREEL
2007
Note de cours de Chimie Pharmaceutiques - Médicaments Biosynthétiques
Bernard MASEREEL
2006
Travaux Dirigés de Biochimie Générale
Severine ROBERT, Anne-Marie MURRAY, Bernard MASEREEL
2005
Travaux Pratiques de Biochimie Générale
Severine ROBERT, Anne-Marie MURRAY, Bernard MASEREEL

Supports Multimédias

2009
Matériel et manipulations en labos pharmaceutiques [DVD]
Severine ROBERT, Philippe DEVEL, Julien DEGLIM, Bernard MASEREEL, Pauline SOVET, Didier LEPIÈCE, Monique NOIRHOMME-FRAITURE
2007
QCM autocorrigé de biochimie (Webcampus) [Audio]
Bernard MASEREEL

Mémoires et thèses supervisés (24)

Publications en série

2009
Drug Design & Development. Drug Design of Zinc-Enzyme inhibitors: Functional, Structural, and Disease Applications: Drug Design of Carbonic anhydrase inhibitors as anticonvulsant agents. Chapter 7, pages 171-191
Anne THIRY, Jean-Michel DOGNÉ, Claudiu SUPURAN

Comptes rendus scientifiques

2009
Synthesis, molecular modeling and pharmacological evaluation of pyrazoloisoquinolines as potential anti-polyarthritis drugs
Jérémie MORTIER, Corinne GANEFF, Caroline REMOUCHAMPS, Emmanuel DEJARDIN, Patrice TALAGA, Jacques PIETTE

Thèses

2010
Design, synthesis molecular modelling and biological evaluation of modulators of the NF-kappa activation
Jérémie MORTIER, J.Y. WINUM
2010
Monofunctionalizations of beta-cyclodextrin, conjugation with recognition patterns, and biological evaluation
Carine BERTOLLA
2008
Design, synthesis and pharmacological evaluation of carbonic anhydrase VII and IX inhibitors
Anne THIRY
2008
Conception, synthèse et évaluation pharmacologique d'inhibiteurs originaux des anhydrases carboniques de type VII et IX
Anne THIRY
2006
Synthèse et étude de coumarines 3,6-disubstituées en tant qu'inhibiteurs de thrombine basés sur le mécanisme
Raphael FRÉDÉRICK
2004
Conception, synthèse et évaluation biologique de 2-thiohydantoïnes en tant qu'inhibiteurs potentiels des cyclooxygénases
Marie-Pierre GAUTHIER
2003
Evaluation pharmacologique de molécules apparentées au torasémide en tant que modulateurs de la voie du thromboxane A2: du criblage in vitro à l'évaluation in vivo de sulfonylurées nitrobenzéniques
Stéphanie ROLIN
2001
Evaluation biologique d'inhibiteurs de l'échange Na+/H+ et Na+/Ca++
Didier LAECKMANN
2000
Conception, synthèse et évaluation biologique de coumarines en tant qu'inhibiteurs de protéases à sérine
Lionel POCHET

Mémoires

2007
Evaluation pharmacologique de modulateurs de la cascade de l'acide arachidonique sue cellules endothéliales et dans un modèle murin d'athérosclérose.
Stéphanie GENON
2006
Evaluation pharmacologique d'indanesulfonamides en tant qu'inhibiteurs d'anhydrases carboniques
Aurélie FRANKART
2004
Evaluation pharmacologique de modulateurs de la cascade de l'acide arachidonique
Caroline VASTERSAEGHER
2004
Evaluation biologique de coumarines en tant qu'inhibiteurs de protéases à sérine de la cascade de la coagulation
Severine ROBERT
2003
Evaluation in vitro et in vivo de l'activité antithrombotique de nouveaux dérivés coumariniques
Marina MOREL
2002
QCM en ligne
Christian POCHET
2001
Rationalisation du mode d'action de dérivés pyridiniques du nimésulide en vue de concevoir une famille originale d'inhibiteurs sélectifs de la cyclooxygénase-2
Caroline CHARLIER
2000
Etude de l'inhibition de l'alpha-chymotrypsine par les dérivés de la coumarine
Jérémie CUISENAIRE
2000
Formation et utilisation de liposomes pour l'étude de la lipophilie de principes actifs
Gaëtan HENRY
2000
Conception, synthèse et évaluation pharmacologique de dérivés originaux du torasémide à propriétés antagonistes du thromboxane A2 et inhibitrices de la thromboxane synthétase
Jean-Michel DOGNÉ
1999
Evaluation biologique d'antagonistes du récepteur du thromboxane A2
Stéphanie ROLIN
1999
Les protéases à sérine: contribution à l'étude du mécanisme d'inhibition de la chymotrypsine par des dérivés de type coumarinique
Marjorie HUYGENS
1999
Analyse structurale et électronique au moyen de méthodes physico-chimiques expérimentales et théoriques de l'interaction entre le récepteur du thromboxane et ses antagonistes
Catherine MICHAUX