Molecular communication between the impaired organelle activity and the nucleus

Numerous pathologies are resulting from alterations in organelle activity and/or function. Indeed, organelles such as mitochondria, lysosomes and endoplasmic reticulum are interconnected and communicate at the molecular level to keep the nucleus informed about their activity/function status level. Retrograde communication is defined as the signalling pathways that are activated in response to organelle dysfunction. The aim of our research is to study cell response (signalling and gene expression) to organelle dysfunction in several models dealing with mitochondrial and lysosomal alterations.

Dr Thierry Arnould
Chargé de Cours
Responsable de l'axe de recherche MITO