Running Projects

• Cross-talk between Brucella and eucaryotic cells : impact of bacterial outer membrane vesicles (OMVs) on the endocytic pathway and other cellular functions (ARC) (2008-2013)
  Jean-Jacques LETESSON

Genetic regulations in eukaryotic models

• Study of RNA polymerase II regulation in the yeast S. pombe (since 2007)
  Damien HERMAND

Other Projects

• Identification and characterization of Brucella abortus effectors (2012-2015)
  Xavier DE BOLLE
• Molecular mechanisms controlling asymmetric cell division and G1 phase in Caulobacter crescentus (2012)
  Regis HALLEZ
• "BARCELONE" project - Bran ARabinoxylan, CEllulose and Lignin Optimized New Extraction process and valorisation project (barcelone) (since 2010)
  Damien HERMAND
• Development and enhancement of the wild type xylanase Scytalidium acidophilum and a mutant thereof. (acidophilum) (2010-2015)
  
• Cross-talk between Brucella and eucaryotic cells: impact of bacterial outer membrane vesicles (OMVs) on the ennocytic pathway and other cellular functions. (2008-2012)
  
• METABOLIC ADAPTATION OF BRUCELLA: IMPACT ON VIRULENCE (201-2013)
  Xavier DE BOLLE, Jean-Jacques LETESSON

Terminated Projects

• Etude de phénotype de surface et de la distribution des cellules infectées par « Brucella » et suivi de l'expression de facteurs de virulence au cours d'une infection en modèle murin (FRFC) (2006)
  
• Etude de l'exopolysaccharide produit par Brucella melitensis 16M (2009)
  Marie GODEFROID
• Charactérisation du mutant PrlR/PrlS de B-melitensis 16 M (2005-2009)
  Jean-Jacques LETESSON, Rosse Mary YANEZ VILLANUEVA
• Etude comportements et modèles formels en biologie moléculaire Brucella (2011)
  France BOONEN
• Study of the Brucella response to quorum sensing signals (2009)
  Julien LEMAIRE
• Analyse des interactions entre le sytème immunitaire non spécifique et Brucella Melitensis en modèle murin (2010)
  Richard COPIN
• Caracterisation of VjbR, a transcriptionnal regulator belonging to the Brucella Quorum Sensing system (2007)
  Sophie BONNOT
• ANIMAL BRUCELLOSIS: GENETICALLY ENGINEERED LIVE VACCINES AGAINST B. MELITENSIS (BRUVAC) (2002-2005)
  Rose-May DELRUE, Jean-Jacques LETESSON
• Study of the stringent response in the regulation of virulence factors in Brucella melitensis 16M (2006)
  Marie DOZOT
• Functional characterization of Brucella virulence genes homologous to symbiosis genes from Rhizobium (2002)
  Amélie DRICOT
• Study of the regulation of flagellum biosynthesis in Brucella melitensis 16M (2005)
  Sandrine LEONARD
• Systematic analysis of B.melitensis 16M transcriptional regulators (2005)
  Valerie HAINE
• Study of the function and the regulation of the flagellum in Brucella (2007)
  Jonathan FEROOZ
• Functional assignement of Omp85, a highly conserved outer membrane protein in Neisseria meningitidis, in surface expression of lipopolysaccharide (LPS). Rôle of its homologue in Brucella abortus (2002)
  Stéphanie GENEVROIS
• Signature Tagged Mutagenesis (STM) as a tool to identify virulence genes of B. melitensis (2003)
  Pascal LESTRATE
• Molecular analysis of the survival of Brucella melitensis in non phagocytic cells (2001)
  Rose-May DELRUE
• Study of Quorum sensing in Brucella melitensis (2004)
  Chantal DESCHAMPS, Bernard TAMINIAU
• Iron uptake in Brucella melitensis (2001)
  Isabelle DANESE

• Identification of polar proteins in Brucella abortus (2010)
  Delphine DOTREPPE
• Cellular assymetry in Brucella abortus, characterization of the role of PdhS and its partners (2008)
  Johann MIGNOLET
• Role of sigma factors in the regulation of virulence genes in Brucella melitensis 16M (2005)
  Marie DELORY
• Study of PdhS, an essential and polar histidine kinase in Brucella abortus (2007)
  Regis HALLEZ, Charles VAN DER HENST

• Characterization of Brucella abortus effectors interacting with Rabs and ERES (2011)
  Marie DE BARSY
• Brucella Intracellular Trafficking: RicA-Rab2 GTPase Interaction Interface (2009)
  Bernard NKENGFAC
• Identification of bacterial regulators of apoptosis using a postgenomic strategy (2009)
  Géraldine LALOUX
• Identification and characterization of bacterial effectors using a post-genomic approach (ARC) (2005-2008)
  Xavier DE BOLLE, Didier FILOPON, Alexandre JAMET, Jean-Jacques LETESSON
• identification à l'échelle génomique et caractérisation d'effecteurs secrétés par Brucella (ARC-URBM) (2004-2008)
  Jean-Jacques LETESSON
• The Brucella ORFeome (2003-2004)
  Xavier DE BOLLE, Amélie DRICOT, Jean-Jacques LETESSON, Vincent VANMULLEM
• Identification des effecteurs potentiellement secrétés par Brucella melitensis 16M (2007)
  Caroline NIJSKENS

Enzymology

• Modificaion of Aspergillus ficuum endoinulinase (MEAF) (2008-2010)
  Isabelle HOUSEN
• Development of soluble alimentary fibers from weaht bran and chicory pulp (Fibersol) (2007-2010)
  Isabelle HOUSEN, Aurélie MAYARD
• Production, improvement and industrialization of acidophilic enzymes (Acidozym) (2003-2007)
  Philippe COPPE, Eric DEPIEREUX, Isabelle HOUSEN
• Analyse et modification des propriétés d'hydrolases d'eucaryotes extrémophiles par génie génétique (2006)
  Bassam AL BALAA, Isabelle HOUSEN
• Industrial methods for purification of thiols proteases from ficus and papaye (2000-2001)
  Philippe COPPE, Luc JOASSIN
• Adaptation of bacterial and fungal xylanases to industrial conditions (1999-2002)
  Bassam AL BALAA, Philippe COPPE, Eric DEPIEREUX, Isabelle HOUSEN, Jean VANDENHAUTE
• Glucose Oxydase (1999-2001)
  Philippe COPPE, Jean-Jacques LETESSON, Carlos ROSSINI

Genetic regulations in eukaryotic models

• Study of the biological roles of « wobble » uridine modifications in three transfert RNA (tRNAUUULys, tRNAUUCGlu and tRNAUUGGln) in the fission yeast Schizosaccharomyces pombe (2011)
  Fanélie BAUER
• Study of lCdc2 activating kinases in S. pombe (2009)
  Maxime DEVOS
• Biochemical and genetic study of the Pch1 function, a new essentail cyclin of the fission yeast Schizosaccharomyces pombe (2007)
  Allan GUIGUEN
• Genetic and biochemical approach of the function of the Pof14 protein, identified as an two-hybrid interactor of the Skp1 protein of Schizosaccharomyces pombe (2005)
  Lionel TAFFOREAU
• Genetic and biochemical approach of the SpSkp1's function and its partners in the control of the transcription and the cell cycle in Schizosaccharomyces pombe (SCF ) (2002)
  Sophie BAMPS
• Study of the role and the regulation of the Mcs6/Mcs2 complex in the yeast Schizosaccharomyces pombe (2000)
  Damien HERMAND

Microchips data analysis

• Application of statistical methods to groups of genes biologically bound in microarrays data analysis. (2011)
  Michael PIERRE
• Transfer of expertise in statistical analysis of microarrays data to the spin-off of service in bioinformatics BioXpr (CHIPSTAT) (2007-2009)
  Anthoula GAIGNEAUX, Eric DEPIEREUX
• Development of a relational database allowing filtering biologically relevant groups of genes in microarray data statistical analysis. (2011)
  Eric BAREKE
• Development of a databank of experimental data for the met analysis and taranversal analysis of biochips data. (Chipotheque) (2011)
  Benoit DE HERTOGH
• Statistical and bioinformatics integration in an expert system for improving the performances of the DNA microchips analyses (CHIPXPR) (2009)
  Fabrice BERGER
• Développement d'un système expert pour l'analyse des données de damiers à ADN (2005-2006)
  
• Performance evaluation of microchips data statistical analysis (Toune) (2004-2007)
  Anthoula GAIGNEAUX, Christophe GENGLER, Eric DEPIEREUX
• Microchips data statistical anlaysis validation for current use of GSK (BioXpt) (2003-2006)
  Benjamin DAMIEN, Eric DEPIEREUX, Christophe GENGLER

Other Projects

• (Televie) (2008-2010)
  Eric DEPIEREUX, Carine MICHIELS
• Expression of acidophil hydrolases modifications involved in degradation of vegetable membran. (2011)
  France BOONEN
• Travail de collaboration avec la s.a. EAT en rapport avec les facteurs de transcription ou de régulations au niveau cellulaire. (URBC-EAT) (2006-2009)
  Martine RAES
• The C. Elegans and Human Orfeomes (2007)
  Philippe LAMESCH
• Validation d'un mutant flagellaire comme candidat vaccinal contre une épreuve infectieuse à Brucella melitensis H38 en modèle murin (CEVA) (2005-2006)
  Jean-Jacques LETESSON
• Epidémiologie de la brucellose bovine en Equateur (2009)
  Jorge RON ROMAN
• Etude du fonctionnement de réseaux de contrôle cellulaire en créant de façon synthétique, au moyen d'éléments génétiques caractérisés, des circuits de connectivités similaires (2007)
  Matija DREZE
• Teaching of biometrics and biostatistics at the National University of Rwanda (UNR01) (2005-2008)
  Eric DEPIEREUX, Gregoire VINCKE
• Implementation of a Brucella melitensis 16M genomic relational database (2005)
  Benjamin DAMIEN, Eric DEPIEREUX, Laila LAHLIMI
• Molecular and proteomic approaches to the diagnistic of bovine paratuberculosis (2005-2006)
  Isabelle DANESE, Jean-Jacques LETESSON, Nicolas TRINCHERO
• Tests diagnostiques maladies du poisson (BIO-X) (2004-2006)
  Jean-Jacques LETESSON
• Collaborative Research Agreement (GSK) (2004-2007)
  Eric DEPIEREUX
• Microarray data analysis (2004-2005)
  Eric DEPIEREUX
• Sélection de couples anticorps monoclonaux-peptides pour un test oligochromatographique (2004-2006)
  Xavier DE BOLLE
• Identification et caractérisation immunologique d'antigènes spécifiques de Mycobacterium avium ssp paratuberculosis à des fins vaccinales (2007)
  Virginie ROUPIE
• Développement d'une technique de détection de produits post-PCR par oligochromatographie (2003-2005)
  Xavier DE BOLLE
• Study of the role of the CTD kinases in Saccharomyces cerevisiae (2005)
  Benoît VAN DRIESSCHE
• Approches protéomiques et moléculaires du diagnostic de la paratuberculose bovine (PARADIAG) (2003-2006)
  Jean-Jacques LETESSON
• Development of a relational database for Brucella melitensis genomic and proteomic knowledge mining (2004)
  Aiko GRYSPEIRT
• Development of an algorithm for the design of Microarrays (in collaboration with Eppendorff Array Technology) (2002-2004)
  Benjamin DAMIEN, Eric DEPIEREUX, Christophe LAMBERT, Nadia LEONARD
• New molecular approach (2005)
  
• Recombinant polypeptides for antigenic mimicry of bacterial surface polysaccharides (2003)
  Mauro BORETTI, Emmanuelle GILLOT, Thierry LAURENT, Pascal MERTENS
• Study of functional interactions between Histones Acetyl-transferases and RNA Polymerases I, II and III in the yeast Saccharomyces cerevisiae (2004)
  Maxime WÉRY
• New vaccinal strategies against the Bovin Respiratory Syncytial virus (BRSV) (2000-2005)
  Jean-Jacques LETESSON, Philippe COPPE, Marie-Ange BENOÎT, Benoit BARAS
• Brucella melitensis 16M genomic (2000-2001)
  Xavier DE BOLLE, Jean-Marc DELROISSE, Eric DEPIEREUX, Jean-Jacques LETESSON, Jean VANDENHAUTE
• Bioinformatic exploitation of the Brucella melitenis 16M genome (2000-2003)
  Xavier DE BOLLE, Eric DEPIEREUX, Christophe LAMBERT, Jean-Jacques LETESSON, Jean VANDENHAUTE
• Practice of Biostatistics on the Web Selflearning tools (2004)
  Philippe CALMANT
• First Spin off: Expertise service in structural physico-chemistry and in modelisation (BIOXPR) (2000-2005)
  Benjamin DAMIEN, Eric DEPIEREUX, François DURANT, Johan WOUTERS
• Conception of affinity peptides based on the structural study of proteins presenting a natural affinity for cellulose substrates (2005)
  Nathalie DE SCHREVEL
• Development of veterinary diagnostic kits (1999-2004)
  Philippe COPPE, Christian EVRARD, Jean-Jacques LETESSON
• Developing an expert system to improve the prediction of the tridimensional protein structure (2003)
  Christophe LAMBERT
• A comparative study of the transcriptional regulation mediated by glucose in the yeast Kluyveromyces lactis and Saccharomyces cerevisiae (2003)
  Godefroid CHARBON
• Peptidomimetics and glycomimetics : diagnostic and vaccinal uses (1999-2002)
  Valery BIELARZ, Jean-Jacques LETESSON, Pascal MERTENS
• Modelization of human rhodopsine (1999-2001)
  Eric DEPIEREUX, Johan WOUTERS
• Psort : analysis and statistical evaluation (1998-2000)
  Katalin DE FAYS, Eric DEPIEREUX
• Development of a microtitration assay for quantifying Pasteurella haemolytica leukotoxin (1998-2000)
  Philippe COPPE, Luc JOASSIN, Jean-Jacques LETESSON
• Author system for developing educational modules. Implementation in a Genetic course (1998-2003)
  Teh AMOUH, Philippe CALMANT, Dominique COPPENS, Eric DEPIEREUX, Monique NOIRHOMME-FRAITURE, Isabelle HOUSEN, Maurice NDAYE-MUKUNA, Cécile PIROTTE, Daniel ROUSSELET, Jacques VAN CLEVE, Jean VANDENHAUTE
• Structural approach of the molecular recognition of monoclonal antibodies and selected peptides, mimics of the lipopolysaccharide of Brucella (2002)
  Thierry LAURENT
• Study of the immunity response and the protection induced by cytoplasmic proteins p39 and BFR of Brucella melitensis 16M in BALB/c mice (2001)
  Ayman AL MARIRI, Anne TIBOR
• Computer analysis of protein sequences and structures of endoxylanases from family (1998-1999)
  Eric DEPIEREUX, Johan WOUTERS
• Study of the structure of macromolecules using bio-physico-chemical methods (biospectroscopies, crystallography, molecular modeling) (1997-1999)
  Eric DEPIEREUX, Christophe LAMBERT, Johan WOUTERS
• Transfer of statistical technics and protein sequence analyzing tools to a Contract Research Organisation (1997-2000)
  Eric DEPIEREUX, Christophe LAMBERT
• Prediction of Structure and Function of the Brucella abortus P39 Gene Product (1997-1998)
  Katalin DE FAYS, Eric DEPIEREUX, Anne TIBOR, Johan WOUTERS
• Study of the role of the A12.2 subunit from RNA polymerase I in Saccharomyces cerevisiae (1997-2001)
  Jean VANDENHAUTE, Vincent VANMULLEM
• Functional characterization of the role of KlMig1p in glucose-mediated transcriptional repression in the yeast Kluyveromyces lactis (2000)
  Isabelle GEORIS
• Non-specific serological reactions in bovine brucellosis : development of diagnostic tools allowing the discrimination between brucellosis and infection caused by Yersinia enterocolitica O:9 (1996-1999)
  Natacha AIDANT, Jean-Jacques LETESSON, Anne TIBOR
• Development of a new diagnostic tool measuring the cellular arm of the immune response : application to enzootic diseases of cattle (1995-1999)
  Dominique GILSON, Jean-Jacques LETESSON, Vincent WEYNANTS, Vinciane DE BERGEYCK
• Derivation of a knowledge-based mean force potential at the atomic level by the inverse Boltzmann's law, for its use in "threading" or fold recognition (1999)
  
• Study of the structure-function relationship of the Omp2b porin of Brucella abortus (1999)
  Jean-Yves PAQUET
• Cloning of the genes involved in the biosynthesis of the LPS in Brucella melitensis (1994-1999)
  Fabrice GODFROID, Jean-Jacques LETESSON
• Study of the bovine immune response against the Bovine Respiratory Syncytial Virus (BRSV). Study of the associated pathological phenomena (1992-1998)
  Isabelle KNOTT, Jean-Jacques LETESSON, Sandra VERCAMMEN
• Genetical and biochemical approach of the functional role of the 3' terminal dimethylation of the rRNA from the small ribosomal subunit in eucaryotes (2001)
  Dominique DEMONTE
• Characterization of three minor outer membrane proteins (Omp) of Brucella sp (1999)
  Anne TIBOR