Running Projects

Design and synthesis of novel drug candidates

• Design and synthesis of indolamine dioxygenase (IDO) for the treatment of cancer (CANTOL) (since 2008)
  Bernard MASEREEL, Johan WOUTERS, Raphael FRÉDÉRICK

Pharmacological evaluation of drug candidates

• pharmacological evaluation of modulators of the arachidonic cascade in atherosclerosis (ATHERO) (since 2006)
  

Other Projects

• Modulation of tissue factor expression on microparticles by multiple myeloma microenvironment and antimyeloma agents (2011-2014)
  Francesca CECCHET, Jean-Michel DOGNÉ, Carine MICHIELS
• Synthesis and evaluation of analogs of harmine as potential inhibitors of DYRK1A : pro-apoptotic compounds in melanoma and gliome models (2011-2014)
  Bernard MASEREEL, Johan WOUTERS
• HOPE4PD (HOPE4PD) (2008-2012)
  Bernard MASEREEL

Terminated Projects

Design and synthesis of novel drug candidates

• Design, synthesis and study of enzyme modulators implicated in tryptophan metabolism and particularly in the kynurenin pathway (2007-2010)
  Raphael FRÉDÉRICK
• Design and synthesis of inhibitors of the NFkB pathway for the treatment of rheumatoid arthritis (PRALTER) (2010)
  Jérémie MORTIER
• Tumoral angiogenesis imaged and traited by radioactive nanoclusters (TARGAN) (2006-2011)
  Maude FRANSOLET, Stephane LUCAS, Carine MICHIELS, Bernard MASEREEL, Marianne CRESPIN, Virginie BOUCHAT, Nicolas MOREAU
• Vectorisation of antitumor drugs by cyclodextrin in the treatment of breast cancer (NANOPHAR) (2008)
  Carine BERTOLLA, Lionel POCHET
• Conception and synthesis of inhibitors of serine proteases (COUMARINE) (2006)
  Raphael FRÉDÉRICK, Severine ROBERT
• Design of an original method to establish pharmacophores : application to thromboxane A2 receptor antagonists (TXA²) (2000-2001)
  François DURANT, Bernard MASEREEL, Joachim PETIT
• Design, synthesis and biological evaluation of inhibitors of cyclooxygenases (COX) (2005)
  Marie-Pierre GAUTHIER, Stéphanie ROLIN
• Development of a pharmacophore describing selective cyclooxygenase-2 (COX-2) inhibitors and design of an original selective COX-2 family (2004)
  Catherine MICHAUX

Pharmacological evaluation of drug candidates

• Vectorisation of antitumor drugs by cyclodextrin in the treatment of breast cancer (NANOPHAR) (2008)
  Carine BERTOLLA, Lionel POCHET
• Design, synthesis and biological evaluation of thromboxane A2 antagonists (TXA2) (2004)
  Stéphanie ROLIN
• Biological evaluation of inhibitors of Na+/H+ and Na+/Ca+ exchanger (2001)
  

Nanooxicology

• In vitro and in vivo toxicological study of three types of nanoparticles od economic interest in the walloon region (NANOTOXICO) (2006-2011)
  Nathalie BELOT, Marie BOTMAN, Valerie DE GLAS, Antoine FATTACCIOLI, Christophe FRIPPIAT, Christine GALLOY, Diane JACQUES, Françoise LAMBINON, Meredith LESCRENIER, Stephane LUCAS, Jerome MARIJSSE, Bernard MASEREEL, Florence NOEL, Jean-Pascal PIRET, Stéphanie ROLIN, Christelle SAOUT, Olivier TOUSSAINT, Sebastien VANKONINGSLOO